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Invitrogen
UCP4 Polyclonal Antibody
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Product Details
PA5-116568
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 201-300 of human SLC25A27 (NP_0042683)
Conjugate
Form
Liquid
Concentration
4.15 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2901199
Product Specific Information
Positive Samples: mouse brain, rat brain
Immunogen sequence: NQPRDKQGRG LLYKSSTD
Target Information
UCP4 is a 323 amino acid mitochondrial uncoupling protein belonging to the large mitochondrial substrate carrier family with three Solcar repeats. UCP4 is a mitochondrial transport carrier that facilitates the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. It reduces the mitochondrial membrane potential in mammalian cells and is involved in thermoregulatory heat production. UCP4 creates proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis resulting in dissipation of energy in the form of heat. UCP4 is usually found in adult and fetal brain, with low levels in spinal chord, corpus callosum and substantia nigra.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Mitochondrial uncoupling protein 4; Solute carrier family 25 member 27; Solute carrier family 25, member 27; UCP 4; uncoupling protein; uncoupling protein 4; uncoupling protein UCP-4
Gene Aliases: 3632410G24Rik; 9430092A03Rik; D530043E16Rik; SLC25A27; UCP4; UNQ772/PRO1566
UniProt ID: (Human) O95847, (Mouse) Q9D6D0
Entrez Gene ID: (Human) 9481, (Mouse) 74011, (Rat) 85262
positive regulation of cell proliferation
negative regulation of mitochondrial membrane potential
cellular triglyceride homeostasis
negative regulation of apoptotic process
regulation of glucose import
negative regulation of mitochondrial calcium ion concentration
neuron death
transport
inner ear development
generation of precursor metabolites and energy
translation
proton transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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