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UGDH Polyclonal Antibody

UGDH Antibody in Immunocytochemistry (ICC/IF)

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UGDH Antibody (13151-1-AP) in ICC/IF

Immunofluorescent analysis of (4% PFA) fixed A549 cells using UGDH antibody (Product # 13151-1-AP) at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L).

UGDH Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Product Details

13151-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 5 publications 5 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200

Immunocytochemistry (ICC/IF)

1:200

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

UGDH Fusion Protein Ag3767 (1-301 aa encoded by BC022781)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MFEIKKICC IGAGYVGGPT CSVIAHMCPE IRVTVVDVNE SRINAWNSPT LPIYEPGLKE VVESCRGKNL FFSTNIDDAI KEADLVFISV NTPTKTYGMG KGRAADLKYI EACARRIVQN SNGYKIVTEK STVPVRAAES IRRIFDANTK PNLNLQVLSN PEFLAEGTAI KDLKNPDRVL IGGDETPEGQ RAVQALCAVY EHWVPREKIL TTNTWSSELS KLAANAFLAQ RISSINSISA LCEATGADVE EVATAIGMDQ RIGNKFLKAS VGFGGSCFQK DVLNLVYLCE ALNLPEVARY WQ (1-301 aa encoded by BC022781)

Target Information

The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

UDP-glucuronate metabolism controls RIPK1-driven liver damage in nonalcoholic steatohepatitis.

Nature communications

Zhang T,Zhang N,Xing J,Zhang S,Chen Y,Xu D,Gu J

Thu May 11 00:00:00 UTC 2023

UDP-glucose accelerates SNAI1 mRNA decay and impairs lung cancer metastasis.

Nature

Wang X,Liu R,Zhu W,Chu H,Yu H,Wei P,Wu X,Zhu H,Gao H,Liang J,Li G,Yang W

Mon Jul 01 00:00:00 UTC 2019

Quantitative proteomic analysis reveals that anti-cancer effects of selenium-binding protein 1 in vivo are associated with metabolic pathways.

PloS one

Ying Q,Ansong E,Diamond AM,Lu Z,Yang W,Bie X

Thu Feb 04 00:00:00 UTC 2016

Quantitative proteomic analysis reveals that anti-cancer effects of selenium-binding protein 1 in vivo are associated with metabolic pathways.

PloS one

Ying Q,Ansong E,Diamond AM,Lu Z,Yang W,Bie X

Thu Feb 04 00:00:00 UTC 2016

UDP-glucose dehydrogenase modulates proteoglycan synthesis in articular chondrocytes: its possible involvement and regulation in osteoarthritis.

Arthritis research & therapy

Wen Y,Li J,Wang L,Tie K,Magdalou J,Chen L,Wang H

Wed Dec 03 00:00:00 UTC 2014

UDP-glucose dehydrogenase modulates proteoglycan synthesis in articular chondrocytes: its possible involvement and regulation in osteoarthritis.

Arthritis research & therapy

Wen Y,Li J,Wang L,Tie K,Magdalou J,Chen L,Wang H

Wed Dec 03 00:00:00 UTC 2014

UDP-glucose dehydrogenase modulates proteoglycan synthesis in articular chondrocytes: its possible involvement and regulation in osteoarthritis.

Arthritis research & therapy

Wen Y,Li J,Wang L,Tie K,Magdalou J,Chen L,Wang H

Wed Dec 03 00:00:00 UTC 2014

UDP-glucose dehydrogenase modulates proteoglycan synthesis in articular chondrocytes: its possible involvement and regulation in osteoarthritis.

Arthritis research & therapy

Wen Y,Li J,Wang L,Tie K,Magdalou J,Chen L,Wang H

Wed Dec 03 00:00:00 UTC 2014

Angelica Sinensis polysaccharides stimulated UDP-sugar synthase genes through promoting gene expression of IGF-1 and IGF1R in chondrocytes: promoting anti-osteoarthritic activity.

PloS one

Wen Y,Li J,Tan Y,Qin J,Xie X,Wang L,Mei Q,Wang H,Magdalou J,Chen L

Thu May 28 00:00:00 UTC 2015

Angelica Sinensis polysaccharides stimulated UDP-sugar synthase genes through promoting gene expression of IGF-1 and IGF1R in chondrocytes: promoting anti-osteoarthritic activity.

PloS one

Wen Y,Li J,Tan Y,Qin J,Xie X,Wang L,Mei Q,Wang H,Magdalou J,Chen L

Thu May 28 00:00:00 UTC 2015

Angelica Sinensis polysaccharides stimulated UDP-sugar synthase genes through promoting gene expression of IGF-1 and IGF1R in chondrocytes: promoting anti-osteoarthritic activity.

PloS one

Wen Y,Li J,Tan Y,Qin J,Xie X,Wang L,Mei Q,Wang H,Magdalou J,Chen L

Thu May 28 00:00:00 UTC 2015

Angelica Sinensis polysaccharides stimulated UDP-sugar synthase genes through promoting gene expression of IGF-1 and IGF1R in chondrocytes: promoting anti-osteoarthritic activity.

PloS one

Wen Y,Li J,Tan Y,Qin J,Xie X,Wang L,Mei Q,Wang H,Magdalou J,Chen L

Thu May 28 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: UDP UGD; UDP-Glc dehydrogenase; UDP-GlcDH; UDP-glucose 6-dehydrogenase; UDP-glucose dehydrogeanse; UDP-glucose dehydrogenase; UDPGDH; uridine diphospho-glucose dehydrogenase

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Gene Aliases: GDH; UDP-GlcDH; UDPGDH; UGD; UGDH

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UniProt ID: (Human) O60701, (Rat) O70199, (Mouse) O70475

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Entrez Gene ID: (Human) 7358, (Rat) 83472, (Mouse) 22235

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Function(s)

UDP-glucose 6-dehydrogenase activity electron carrier activity NAD binding catalytic activity oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

Process(es)

gastrulation with mouth forming second UDP-glucuronate biosynthetic process oxidation-reduction process carbohydrate metabolic process UDP-glucose metabolic process glycosaminoglycan biosynthetic process metabolic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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UGDH Polyclonal Antibody

UGDH Antibody (13151-1-AP) in ICC/IF

Product Details

13151-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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