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Invitrogen
UGT1A6 Polyclonal Antibody
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UGT1A6 Antibody (PA5-116104) in IHC (P)
Immunohistochemistry analysis of UGT1A6 in rat colorectal tissue. Samples were treated with formaldehyde and treated with citrate buffer for antigen retrieval, blocked, and incubated (1.5 hours at 22°C) with polyclonal antibody (Product # PA5-116104) at a dilution of 1:100. Secondary staining was applied with HRP conjugated anti-Rabbit.
Product Details
PA5-116104
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human UGT1A6(Accession P19224), corresponding to amino acid residues V60-T110.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2900738
Product Specific Information
Antibody detects endogenous levels of total UGT1A6.
Target Information
UGT1A6 is a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme is active on phenolic and planar compounds. Alternative splicing in the unique 5' end of this gene results in two transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: A1; MGC29860; P-nitrophenol specific; P-nitrophenol-specific UDPGT; Phenol UDP-glucuronosyltransferase; Phenol-metabolizing UDP-glucuronosyltransferase; UDP glucuronosyltransferase 1 family, polypeptide A6; UDP glucuronosyltransferase 1A6; UDP glycosyltransferase 1 family, polypeptide A6; UDP-glucuronosyltransferase 1 family polypeptide A6s; UDP-glucuronosyltransferase 1-6; UDP-glucuronosyltransferase 1-F; UDP-glucuronosyltransferase 1A6; UDPGT 1-6; UGP1A1; UGT-1F; UGT1*6; UGT1-06; UGT1.6; UGT1A6; UGT1A7
Gene Aliases: GNT1; HLUGP; HLUGP1; UDPGT; UDPGT 1-6; UGT1; UGT1-06; UGT1.6; UGT1A6; Ugt1a6a; UGT1A6S; Ugt1a7; UGT1F
UniProt ID: (Human) P19224, (Rat) P08430, (Mouse) Q64435
Entrez Gene ID: (Human) 54578, (Rat) 113992, (Mouse) 94284
metabolic process
flavonoid biosynthetic process
glucuronate metabolic process
cellular response to hormone stimulus
flavonoid glucuronidation
xenobiotic glucuronidation
liver development
response to organic cyclic compound
4-chlorobiphenyl metabolic process
response to lipopolysaccharide
response to peptide hormone
cellular response to glucocorticoid stimulus
xenobiotic metabolic process
cellular glucuronidation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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