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Invitrogen
UGT1A9 Polyclonal Antibody
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UGT1A9 Antibody (PA5-120467) in IHC (P)
Immunohistochemistry analysis of UGT1A9 in paraffin-embedded human liver cancer. Samples were incubated with UGT1A9 Polyclonal antibody (Product # PA5-120467) using a dilution of 1:200 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Product Details
PA5-120467
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 26-250 of human UGT1A9 (NP_066307.1).
Conjugate
Form
Liquid
Concentration
0.56 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2914039
Product Specific Information
Positive test controls include: A-549, HT-29, MCF7, HeLa, Mouse liver. The target is usually found in the following locations: Endoplasmic reticulum membrane, Microsome, Single-pass membrane protein.
Immunogen sequence: GKLLVVPMDG SHWFTMRSVV EKLILRGHEV VVVMPEVSWQ LGRSLNCTVK TYSTSYTLED LDREFKAFAH AQWKAQVRSI YSLLMGSYND IFDLFFSNCR SLFKDKKLVE YLKESSFDAV FLDPFDNCGL IVAKYFSLPS VVFARGILCH YLEEGAQCPA PLSYVPRILL GFSDAMTFKE RVRNHIMHLE EHLLCHRFFK NALEIASEIL QTPVTEYDLY SHTSI
Target Information
UGT1A9 is a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. UGT1A9 is active on phenols.This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenols. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: lugP4; UDP glucuronosyltransferase 1 family, polypeptide A9; UDP glycosyltransferase 1 family polypeptide A10; UDP glycosyltransferase 1 family polypeptide A11; UDP glycosyltransferase 1 family polypeptide A12; UDP glycosyltransferase 1 family, polypeptide A10; UDP glycosyltransferase 1 family, polypeptide A9; UDP-glucuronosyltransferase 1 family polypeptide A9s; UDP-glucuronosyltransferase 1-7; UDP-glucuronosyltransferase 1-9; UDP-glucuronosyltransferase 1-I; UDP-glucuronosyltransferase 1A9; UDPGT; UDPGT 1-9; UGT-1I; UGT1A12; UGT1A9; UGTP4
Gene Aliases: GNT1; HLUGP4; LUGP4; mUGTBr/P; UDPGT; UDPGT 1-9; UGT-1I; UGT1; UGT1-09; UGT1-9; UGT1.9; Ugt1a10; Ugt1a11; Ugt1a12; UGT1A9; UGT1A9S; UGT1AI; UGT1I; UGTP4
UniProt ID: (Human) O60656, (Mouse) Q62452
Entrez Gene ID: (Human) 54600, (Mouse) 394434, (Rat) 396552
retinoic acid binding
glucuronosyltransferase activity
protein homodimerization activity
protein heterodimerization activity
enzyme inhibitor activity
protein kinase C binding
steroid binding
fatty acid binding
drug binding
transferase activity
transferase activity, transferring glycosyl groups
transferase activity, transferring hexosyl groups
enzyme binding
molecular_function
xenobiotic metabolic process
metabolic process
retinoic acid metabolic process
flavone metabolic process
cellular glucuronidation
flavonoid glucuronidation
xenobiotic glucuronidation
flavonoid biosynthetic process
cellular response to hormone stimulus
negative regulation of catalytic activity
biological_process
drug metabolic process
negative regulation of fatty acid metabolic process
negative regulation of transferase activity
negative regulation of cellular glucuronidation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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