Proteintech

UGT8 Polyclonal Antibody

UGT8 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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UGT8 Antibody (17982-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using 17982-1-AP (UGT8 Antibody) at dilution of 1:50 (under 40x lens).

UGT8 Antibody in Immunoprecipitation (IP)

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Product Details

17982-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 7 publications 7 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

UGT8 Fusion Protein Ag12393 (38-402 aa encoded by BC075069)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.13 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody specifically recognizes the endogenous UGT8.

Immunogen sequence: FKTLASALH ERGHHTVFLL SEGRDIAPSN HYSLQRYPGI FNSTTSDAFL QSKMRNIFSG RLTAIELFDI LDHYTKNCDL MVGNHALIQG LKKEKFDLLL VDPNDMCGFV IAHLLGVKYA VFSTGLWYPA EVGAPAPLAY VPEFNSLLTD RMNLLQRMKN TGVYLISRLG VSFLVLPKYE RIMQKYNLLP EKSMYDLVHG SSLWMLCTDV ALEFPRPTLP NVVYVGGILT KPASPLPEDL QRWVNGANEH GFVLVSFGAG VKYLSEDIAN KLAGALGRLP QKVIWRFSGP KPKNLGNNTK LIEWLPQNDL LGHSKIKAFL SHGGLNSIFE TMYHGVPVVG IPLFGDHYDT MTRVQAKGMG ILLEWK (38-402 aa encoded by BC075069)

Target Information

UGT8 (UDP-galactose-ceramide galactosyltransferase, 2-hydroxyacylsphingosine 1-beta-galactosyltransferase) is a 541 amino acid, single pass membrane protein of the UDP-glycosyltransferase family. UGT8 is believed to be primarily involved with the metabolism of sphingolipids and galactosylceramide biosynthesis. UGT8 is one of six genes whose elevated expression has been correlated with a significantly increased the risk of lung metastases in breast cancer patients. As such, UGT8 may be a significant index of tumor aggressiveness and a potential marker for the prognostic evaluation of lung metastases in breast cancer. UGT8 is ubiquitously expressed with highest levels found in central and peripheral nervous systems and is up-regulated in breast cancers.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

The incubation of cocaine craving is dissociated from changes in glial cell markers within prefrontal cortex and nucleus accumbens of rats.

Addiction neuroscience

Webb SM,Sacramento AD,McCloskey MA,Wroten MG,Ploense KL,Kippin TE,Ben-Shahar O,Szumlinski KK

Thu Sep 01 00:00:00 UTC 2022

Metabolic Enzyme Alterations and Astrocyte Dysfunction in a Murine Model of Alexander Disease With Severe Reactive Gliosis.

Molecular & cellular proteomics : MCP

Heaven MR,Herren AW,Flint DL,Pacheco NL,Li J,Tang A,Khan F,Goldman JE,Phinney BS,Olsen ML

Sat Jan 01 00:00:00 UTC 2022

Metabolic Enzyme Alterations and Astrocyte Dysfunction in a Murine Model of Alexander Disease With Severe Reactive Gliosis.

Molecular & cellular proteomics : MCP

Heaven MR,Herren AW,Flint DL,Pacheco NL,Li J,Tang A,Khan F,Goldman JE,Phinney BS,Olsen ML

Sat Jan 01 00:00:00 UTC 2022

Metabolic Enzyme Alterations and Astrocyte Dysfunction in a Murine Model of Alexander Disease With Severe Reactive Gliosis.

Molecular & cellular proteomics : MCP

Heaven MR,Herren AW,Flint DL,Pacheco NL,Li J,Tang A,Khan F,Goldman JE,Phinney BS,Olsen ML

Sat Jan 01 00:00:00 UTC 2022

Metabolic Enzyme Alterations and Astrocyte Dysfunction in a Murine Model of Alexander Disease With Severe Reactive Gliosis.

Molecular & cellular proteomics : MCP

Heaven MR,Herren AW,Flint DL,Pacheco NL,Li J,Tang A,Khan F,Goldman JE,Phinney BS,Olsen ML

Sat Jan 01 00:00:00 UTC 2022

Uronic acid metabolic process-related gene expression-based signature predicts overall survival of glioma.

Bioscience reports

Feng Y,Li G,Shi Z,Yan X,Li R,Zhai Y,Chang Y,Wang D,Kahlert UD,Zhang W,Yuan F

Fri Jan 29 00:00:00 UTC 2021

Circular RNAs of UDP-Glycosyltransferase (UGT) Genes Expand the Complexity and Diversity of the UGT Transcriptome.

Molecular pharmacology

Hu DG,Mackenzie PI,Hulin JA,McKinnon RA,Meech R

Tue Jun 01 00:00:00 UTC 2021

Microarray analyses of lncRNAs and mRNAs expression profiling associated with diabetic peripheral neuropathy in rats.

Journal of cellular biochemistry

Guo G,Ren S,Kang Y,Liu Y,Duscher D,Machens HG,Chen Z

Sun Sep 01 00:00:00 UTC 2019

Inhibition of UGT8 suppresses basal-like breast cancer progression by attenuating sulfatide-αVβ5 axis.

The Journal of experimental medicine

Cao Q,Chen X,Wu X,Liao R,Huang P,Tan Y,Wang L,Ren G,Huang J,Dong C

Mon Jun 04 00:00:00 UTC 2018

Inhibition of UGT8 suppresses basal-like breast cancer progression by attenuating sulfatide-αVβ5 axis.

The Journal of experimental medicine

Cao Q,Chen X,Wu X,Liao R,Huang P,Tan Y,Wang L,Ren G,Huang J,Dong C

Mon Jun 04 00:00:00 UTC 2018

Inhibition of UGT8 suppresses basal-like breast cancer progression by attenuating sulfatide-αVβ5 axis.

The Journal of experimental medicine

Cao Q,Chen X,Wu X,Liao R,Huang P,Tan Y,Wang L,Ren G,Huang J,Dong C

Mon Jun 04 00:00:00 UTC 2018

Inhibition of UGT8 suppresses basal-like breast cancer progression by attenuating sulfatide-αVβ5 axis.

The Journal of experimental medicine

Cao Q,Chen X,Wu X,Liao R,Huang P,Tan Y,Wang L,Ren G,Huang J,Dong C

Mon Jun 04 00:00:00 UTC 2018

Diffusion Efficiency and Bioavailability of Resveratrol Administered to Rat Brain by Different Routes: Therapeutic Implications.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

Shu XH,Wang LL,Li H,Song X,Shi S,Gu JY,Wu ML,Chen XY,Kong QY,Liu J

Wed Apr 01 00:00:00 UTC 2015

Diffusion Efficiency and Bioavailability of Resveratrol Administered to Rat Brain by Different Routes: Therapeutic Implications.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

Shu XH,Wang LL,Li H,Song X,Shi S,Gu JY,Wu ML,Chen XY,Kong QY,Liu J

Wed Apr 01 00:00:00 UTC 2015

Diffusion Efficiency and Bioavailability of Resveratrol Administered to Rat Brain by Different Routes: Therapeutic Implications.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

Shu XH,Wang LL,Li H,Song X,Shi S,Gu JY,Wu ML,Chen XY,Kong QY,Liu J

Wed Apr 01 00:00:00 UTC 2015

Diffusion Efficiency and Bioavailability of Resveratrol Administered to Rat Brain by Different Routes: Therapeutic Implications.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

Shu XH,Wang LL,Li H,Song X,Shi S,Gu JY,Wu ML,Chen XY,Kong QY,Liu J

Wed Apr 01 00:00:00 UTC 2015

Evaluation of resveratrol sensitivities and metabolic patterns in human and rat glioblastoma cells.

Cancer chemotherapy and pharmacology

Sun Z,Shi S,Li H,Shu XH,Chen XY,Kong QY,Liu J

Fri Nov 01 00:00:00 UTC 2013

Evaluation of resveratrol sensitivities and metabolic patterns in human and rat glioblastoma cells.

Cancer chemotherapy and pharmacology

Sun Z,Shi S,Li H,Shu XH,Chen XY,Kong QY,Liu J

Fri Nov 01 00:00:00 UTC 2013

Evaluation of resveratrol sensitivities and metabolic patterns in human and rat glioblastoma cells.

Cancer chemotherapy and pharmacology

Sun Z,Shi S,Li H,Shu XH,Chen XY,Kong QY,Liu J

Fri Nov 01 00:00:00 UTC 2013

Evaluation of resveratrol sensitivities and metabolic patterns in human and rat glioblastoma cells.

Cancer chemotherapy and pharmacology

Sun Z,Shi S,Li H,Shu XH,Chen XY,Kong QY,Liu J

Fri Nov 01 00:00:00 UTC 2013

Bioinformatics

Protein Aliases: 2-hydroxyacylsphingosine 1-beta-galactosyltransferase; Ceramide UDP-galactosyltransferase; Cerebroside synthase; CGalT; UDP galactosyltransferase 8; UDP galactosyltransferase 8A; UDP-galactose ceramide galactosyltransferase; UDP-galactose-ceramide galactosyltransferase; UDP-galactose-ceramide galactosyltransferase 8; UDP-galactose-ceramide galactosyltransferase 8A; UDP-glucuronosyltransferase 8; uridine diphosphate glycosyltransferase 8

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Gene Aliases: AI850488; AW455908; CGT; mCerGT; UGT4; UGT8; Ugt8a

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UniProt ID: (Human) Q16880, (Rat) Q09426, (Mouse) Q64676

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Entrez Gene ID: (Human) 7368, (Rat) 50555, (Mouse) 22239

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Function(s)

2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity glucuronosyltransferase activity N-acylsphingosine galactosyltransferase activity ceramide glucosyltransferase activity transferase activity transferase activity, transferring glycosyl groups transferase activity, transferring hexosyl groups

Process(es)

protein localization to paranode region of axon lipid metabolic process sphingolipid metabolic process cytoskeleton organization metabolic process glycolipid biosynthetic process flavonoid biosynthetic process paranodal junction assembly cellular response to hormone stimulus myelination neuron projection morphogenesis flavonoid glucuronidation galactosylceramide biosynthetic process glycosphingolipid metabolic process central nervous system development peripheral nervous system development glycosphingolipid biosynthetic process axo-dendritic transport

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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UGT8 Polyclonal Antibody

UGT8 Antibody (17982-1-AP) in IHC (P)

Product Details

17982-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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