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Invitrogen
ULBP1 Monoclonal Antibody (237104)
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Product Details
MA5-23945
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rat
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
237104
Immunogen
BaF3 mouse pro-B cell line transfected with mouse ULBP-1/MULT-1
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Purification
Protein A/G
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2576223
Product Specific Information
Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
ULBP1 is the ligand for the NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: NKG2D ligand; NKG2D ligand 1; NKG2D ligand1; UL16-binding protein-like transcript 1; ULBP; ULBP 1
Gene Aliases: A430108B07Rik; MULT1
Entrez Gene ID: (Mouse) 77777
T cell mediated cytotoxicity
antigen processing and presentation of peptide antigen via MHC class I
positive regulation of immune response to tumor cell
natural killer cell activation
positive regulation of interferon-gamma production
positive regulation of natural killer cell activation
natural killer cell mediated cytotoxicity
susceptibility to natural killer cell mediated cytotoxicity
positive regulation of macrophage activation
positive regulation of nitric oxide biosynthetic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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