Proteintech

UNC13D/Munc13-4 Polyclonal Antibody

UNC13D/Munc13-4 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 13

UNC13D/Munc13-4 Antibody (16905-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human thymus tissue slide using 16905-1-AP ( UNC13D/Munc13-4 antibody at dilution of 1:200 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

UNC13D/Munc13-4 Antibody in Western Blot (WB)

UNC13D/Munc13-4 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

16905-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

UNC13D/Munc13-4 Fusion Protein Ag10519 (1-327 aa encoded by BC067084)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.23 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MATLLSHPQ QRPPFLRQAI KIRRRRVRDL QDPPPQMAPE IQPPSHHFSP EQRALLYEDA LYTVLHRLGH PEPNHVTEAS ELLRYLQEAF HVEPEEHQQT LQRVRELEKP IFCLKATVKQ AKGILGKDVS GFSDPYCLLG IEQGVGVPGG SPGSRHRQKA VVRHTIPEEE THRTQVITQT LNPVWDETFI LEFEDITNAS FHLDMWDLDT VESVRQKLGE LTDLHGLRRI FKEARKDKGQ DDFLGNVVLR LQDLRCREDQ WYPLEPRTET YPDRGQCHLQ FQLIHKRRAT SASRSQPSYT VHLHLLQQLV SHEVTQHEAG STSWDGSL (1-327 aa encoded by BC067084)

Target Information

This gene encodes a protein that is a member of the UNC13 family, containing similar domain structure as other family members but lacking an N-terminal phorbol ester-binding C1 domain present in other Munc13 proteins. The protein appears to play a role in vesicle maturation during exocytosis and is involved in regulation of cytolytic granules secretion. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis type 3, a genetically heterogeneous, rare autosomal recessive disorder.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Integrative omics indicate FMRP sequesters mRNA from translation and deadenylation in human neuronal cells.

Molecular cell

Kurosaki T,Mitsutomi S,Hewko A,Akimitsu N,Maquat LE

Thu Dec 01 00:00:00 UTC 2022

Alternative UNC13D Promoter Encodes a Functional Munc13-4 Isoform Predominantly Expressed in Lymphocytes and Platelets.

Frontiers in immunology

Galgano D,Soheili T,Voss M,Torralba-Raga L,Tesi B,Cichocki F,Andre I,Rettig J,Cavazzana M,Bryceson Y

Fri Apr 02 00:00:00 UTC 2021

A novel Munc13-4/S100A10/annexin A2 complex promotes Weibel-Palade body exocytosis in endothelial cells.

Molecular biology of the cell

Chehab T,Santos NC,Holthenrich A,Koerdt SN,Disse J,Schuberth C,Nazmi AR,Neeft M,Koch H,Man KNM,Wojcik SM,Martin TFJ,van der Sluijs P,Brose N,Gerke V

Thu Jun 15 00:00:00 UTC 2017

A novel Munc13-4/S100A10/annexin A2 complex promotes Weibel-Palade body exocytosis in endothelial cells.

Molecular biology of the cell

Chehab T,Santos NC,Holthenrich A,Koerdt SN,Disse J,Schuberth C,Nazmi AR,Neeft M,Koch H,Man KNM,Wojcik SM,Martin TFJ,van der Sluijs P,Brose N,Gerke V

Thu Jun 15 00:00:00 UTC 2017

A novel Munc13-4/S100A10/annexin A2 complex promotes Weibel-Palade body exocytosis in endothelial cells.

Molecular biology of the cell

Chehab T,Santos NC,Holthenrich A,Koerdt SN,Disse J,Schuberth C,Nazmi AR,Neeft M,Koch H,Man KNM,Wojcik SM,Martin TFJ,van der Sluijs P,Brose N,Gerke V

Thu Jun 15 00:00:00 UTC 2017

A novel Munc13-4/S100A10/annexin A2 complex promotes Weibel-Palade body exocytosis in endothelial cells.

Molecular biology of the cell

Chehab T,Santos NC,Holthenrich A,Koerdt SN,Disse J,Schuberth C,Nazmi AR,Neeft M,Koch H,Man KNM,Wojcik SM,Martin TFJ,van der Sluijs P,Brose N,Gerke V

Thu Jun 15 00:00:00 UTC 2017

Transcriptional regulation of Munc13-4 expression in cytotoxic lymphocytes is disrupted by an intronic mutation associated with a primary immunodeficiency.

The Journal of experimental medicine

Cichocki F,Schlums H,Li H,Stache V,Holmes T,Lenvik TR,Chiang SC,Miller JS,Meeths M,Anderson SK,Bryceson YT

Mon Jun 02 00:00:00 UTC 2014

Transcriptional regulation of Munc13-4 expression in cytotoxic lymphocytes is disrupted by an intronic mutation associated with a primary immunodeficiency.

The Journal of experimental medicine

Cichocki F,Schlums H,Li H,Stache V,Holmes T,Lenvik TR,Chiang SC,Miller JS,Meeths M,Anderson SK,Bryceson YT

Mon Jun 02 00:00:00 UTC 2014

Familial hemophagocytic lymphohistiocytosis type 3 (FHL3) caused by deep intronic mutation and inversion in UNC13D.

Blood

Meeths M,Chiang SC,Wood SM,Entesarian M,Schlums H,Bang B,Nordenskjöld E,Björklund C,Jakovljevic G,Jazbec J,Hasle H,Holmqvist BM,Rajic L,Pfeifer S,Rosthøj S,Sabel M,Salmi TT,Stokland T,Winiarski J,Ljunggren HG,Fadeel B,Nordenskjöld M,Henter JI,Bryceson YT

Thu Nov 24 00:00:00 UTC 2011

Familial hemophagocytic lymphohistiocytosis type 3 (FHL3) caused by deep intronic mutation and inversion in UNC13D.

Blood

Thu Nov 24 00:00:00 UTC 2011

Bioinformatics

Protein Aliases: munc 13-4; Munc13-4; Protein unc-13 homolog D

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Gene Aliases: FHL3; HLH3; HPLH3; Munc13-4; UNC13D

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UniProt ID: (Human) Q70J99

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Entrez Gene ID: (Human) 201294

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Function(s)

protein binding Rab GTPase binding

Process(es)

granuloma formation germinal center formation phagocytosis regulation of mast cell degranulation natural killer cell degranulation positive regulation of exocytosis defense response to virus positive regulation of substrate adhesion-dependent cell spreading positive regulation of regulated secretory pathway

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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UNC13D/Munc13-4 Polyclonal Antibody

UNC13D/Munc13-4 Antibody (16905-1-AP) in IHC (P)

Product Details

16905-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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