Product References
Cathepsin D overexpression in the nervous system rescues lethality and Aβ42 accumulation of cathepsin D systemic knockout in vivo.
Acta pharmaceutica Sinica. B
Ouyang X,Wani WY,Benavides GA,Redmann MJ,Vo H,van Groen T,Darley-Usmar VM,Zhang J
459140 was used in Western Blot to find that over-expression of Cathepsin D extended the lifespan of the CDKO mice, partially rescues proteasomal deficits and the accumulation of Aβ42 in the CDKO.
Sun Oct 01 00:00:00 UTC 2023
Enhancement of anaerobic glycolysis - a role of PGC-1α4 in resistance exercise.
Nature communications
Koh JH,Pataky MW,Dasari S,Klaus KA,Vuckovic I,Ruegsegger GN,Kumar AP,Robinson MM,Nair KS
459140 was used in Western Blotting to provide a mechanistic link between RET and improved glucose metabolism, offering an important therapeutic target to counteract aging and inactivity-induced metabolic diseases benefitting those who cannot exercise due to many reasons.
Thu Apr 28 00:00:00 UTC 2022
Cardiac disruption of SDHAF4-mediated mitochondrial complex II assembly promotes dilated cardiomyopathy.
Nature communications
Wang X,Zhang X,Cao K,Zeng M,Fu X,Zheng A,Zhang F,Gao F,Zou X,Li H,Li M,Lv W,Xu J,Long J,Zang W,Chen J,Gao F,Ding J,Liu J,Feng Z
459140 was used in Western Blotting to reveal a vital role for complex II assembly in the development of dilated cardiomyopathy and provide additional insights into therapeutic interventions for heart diseases.
Fri Jul 08 00:00:00 UTC 2022
PACSIN1 is indispensable for amphisome-lysosome fusion during basal autophagy and subsets of selective autophagy.
PLoS genetics
Oe Y,Kakuda K,Yoshimura SI,Hara N,Hasegawa J,Terawaki S,Kimura Y,Ikenaka K,Suetsugu S,Mochizuki H,Yoshimori T,Nakamura S
459140 was used in Western Blotting to demonstrate the amphisome-lysosome fusion process is preferentially regulated in response to nutrient state and stress, and PACSIN1 is a key to specificity during autophagy.
Wed Jun 01 00:00:00 UTC 2022
Optic atrophy-associated TMEM126A is an assembly factor for the ND4-module of mitochondrial complex I.
Proceedings of the National Academy of Sciences of the United States of America
Formosa LE,Reljic B,Sharpe AJ,Hock DH,Muellner-Wong L,Stroud DA,Ryan MT
459140 was used in Western Blot to show that TMEM126A, a protein that is mutated in patients with autosomal-recessive optic atrophy, participates directly in the assembly of mitochondrial complex I.
Tue Apr 27 00:00:00 UTC 2021
Optic atrophy-associated TMEM126A is an assembly factor for the ND4-module of mitochondrial complex I.
Proceedings of the National Academy of Sciences of the United States of America
Formosa LE,Reljic B,Sharpe AJ,Hock DH,Muellner-Wong L,Stroud DA,Ryan MT
459140 was used in Western Blot to show that TMEM126A, a protein that is mutated in patients with autosomal-recessive optic atrophy, participates directly in the assembly of mitochondrial complex I.
Tue Apr 27 00:00:00 UTC 2021
Reperfusion mediates heme impairment with increased protein cysteine sulfonation of mitochondrial complex III in the post-ischemic heart.
Journal of molecular and cellular cardiology
Chen CL,Kang PT,Zhang L,Xiao K,Zweier JL,Chilian WM,Chen YR
459140 was used in Western Blotting to show that reperfusion-mediated heme damage with increased PrSO3H controls oxidative injury to complex III and aggravates mitochondrial dysfunction in the post-ischemic heart.
Wed Dec 01 00:00:00 UTC 2021
Interspecies Differences in Proteome Turnover Kinetics Are Correlated With Life Spans and Energetic Demands.
Molecular & cellular proteomics : MCP
Swovick K,Firsanov D,Welle KA,Hryhorenko JR,Wise JP,George C,Sformo TL,Seluanov A,Gorbunova V,Ghaemmaghami S
459140 was used in Western Blot to suggest that in lieu of a rapid constitutive turnover, long-lived species may have evolved more energetically efficient mechanisms for selective detection and clearance of damaged proteins.
Fri Mar 11 00:00:00 UTC 2022
Interspecies Differences in Proteome Turnover Kinetics Are Correlated With Life Spans and Energetic Demands.
Molecular & cellular proteomics : MCP
Swovick K,Firsanov D,Welle KA,Hryhorenko JR,Wise JP,George C,Sformo TL,Seluanov A,Gorbunova V,Ghaemmaghami S
459140 was used in Western Blot to suggest that in lieu of a rapid constitutive turnover, long-lived species may have evolved more energetically efficient mechanisms for selective detection and clearance of damaged proteins.
Fri Mar 11 00:00:00 UTC 2022
Genome-wide CRISPRi screening identifies OCIAD1 as a prohibitin client and regulatory determinant of mitochondrial Complex III assembly in human cells.
eLife
Le Vasseur M,Friedman J,Jost M,Xu J,Yamada J,Kampmann M,Horlbeck MA,Salemi MR,Phinney BS,Weissman JS,Nunnari J
459140 was used in Western Blotting to identify determinants of mETC function by screening a genome-wide human CRISPRi library under oxidative metabolic conditions with selective inhibition of mitochondrial Complex III and identified ovarian carcinoma immunoreactive antigen (OCIA) domain-containing protein 1 (OCIAD1) as a Complex III assembly factor.
Wed May 26 00:00:00 UTC 2021
Fatal perinatal mitochondrial cardiac failure caused by recurrent de novo duplications in the ATAD3 locus.
Med (New York, N.Y.)
Frazier AE,Compton AG,Kishita Y,Hock DH,Welch AE,Amarasekera SSC,Rius R,Formosa LE,Imai-Okazaki A,Francis D,Wang M,Lake NJ,Tregoning S,Jabbari JS,Lucattini A,Nitta KR,Ohtake A,Murayama K,Amor DJ,McGillivray G,Wong FY,van der Knaap MS,Jeroen Vermeulen R,Wiltshire EJ,Fletcher JM,Lewis B,Baynam G,Ellaway C,Balasubramaniam S,Bhattacharya K,Freckmann ML,Arbuckle S,Rodriguez M,Taft RJ,Sadedin S,Cowley MJ,Minoche AE,Calvo SE,Mootha VK,Ryan MT,Okazaki Y,Stroud DA,Simons C,Christodoulou J,Thorburn DR
459140 was used in Western Blot to investigate the ATAD3 locus in 17 subjects from 16 unrelated families with suspected mitochondrial disease, using Whole exome, whole genome and long-read DNA sequencing techniques combined with studies of RNA and quantitative proteomics.
Fri Jan 15 00:00:00 UTC 2021
Identification of long-lived proteins in the mitochondria reveals increased stability of the electron transport chain.
Developmental cell
Krishna S,Arrojo E Drigo R,Capitanio JS,Ramachandra R,Ellisman M,Hetzer MW
459140 was used in Western Blotting to suggest that modulating protein longevity within the ETC is critical for mitochondrial proteome maintenance and the robustness of mitochondrial function.
Mon Nov 08 00:00:00 UTC 2021
GLP-1 Receptor Signaling in Astrocytes Regulates Fatty Acid Oxidation, Mitochondrial Integrity, and Function.
Cell metabolism
Timper K,Del Río-Martín A,Cremer AL,Bremser S,Alber J,Giavalisco P,Varela L,Heilinger C,Nolte H,Trifunovic A,Horvath TL,Kloppenburg P,Backes H,Brüning JC
459140 was used in Western Blotting to demonstrate that glucagon-like peptide (GLP)-1 inhibits glucose uptake and promotes β-oxidation in cultured astrocytes.
Tue Jun 02 00:00:00 UTC 2020
Autophagy inhibition prevents glucocorticoid-increased adiposity via suppressing BAT whitening.
Autophagy
Deng J,Guo Y,Yuan F,Chen S,Yin H,Jiang X,Jiao F,Wang F,Ji H,Hu G,Ying H,Chen Y,Zhai Q,Xiao F,Guo F
459140 was used in Western Blotting to demonstrate that glucorticoid triggers a profound whitening of BAT, and inhibition of autophagy or BTG1 in BAT alleviates glucocorticoid-increased fat mass.
Sun Mar 01 00:00:00 UTC 2020
Herba Houttuyniae Extract Benefits Hyperlipidemic Mice via Activation of the AMPK/PGC-1α/Nrf2 Cascade.
Nutrients
Cao K,Lv W,Liu X,Fan Y,Wang K,Feng Z,Liu J,Zang W,Xing L,Liu J
459140 was used in Western Blot to link the AMPK/PGC-1α/Nrf2 cascade to hyperlipidemia-induced liver and heart impairments and demonstrate the protective effect of HAE as an AMPK activator in the prevention of hyperlipidemia-related diseases.
Tue Jan 07 00:00:00 UTC 2020
Herba Houttuyniae Extract Benefits Hyperlipidemic Mice via Activation of the AMPK/PGC-1α/Nrf2 Cascade.
Nutrients
Cao K,Lv W,Liu X,Fan Y,Wang K,Feng Z,Liu J,Zang W,Xing L,Liu J
459140 was used in Western Blot to link the AMPK/PGC-1α/Nrf2 cascade to hyperlipidemia-induced liver and heart impairments and demonstrate the protective effect of HAE as an AMPK activator in the prevention of hyperlipidemia-related diseases.
Tue Jan 07 00:00:00 UTC 2020
The Mouse Heart Mitochondria N Terminome Provides Insights into ClpXP-Mediated Proteolysis.
Molecular & cellular proteomics : MCP
Hofsetz E,Demir F,Szczepanowska K,Kukat A,Kizhakkedathu JN,Trifunovic A,Huesgen PF
459140 was used in Western Blot to highlight the dual function of ClpXP as a regulator of major mitochondrial functions and controller of mitochondria proteostasis.
Sat Aug 01 00:00:00 UTC 2020
The Mouse Heart Mitochondria N Terminome Provides Insights into ClpXP-Mediated Proteolysis.
Molecular & cellular proteomics : MCP
Hofsetz E,Demir F,Szczepanowska K,Kukat A,Kizhakkedathu JN,Trifunovic A,Huesgen PF
459140 was used in Western Blot to highlight the dual function of ClpXP as a regulator of major mitochondrial functions and controller of mitochondria proteostasis.
Sat Aug 01 00:00:00 UTC 2020
Leigh Syndrome Due to NDUFV1 Mutations Initially Presenting as LBSL.
Genes
Borna NN,Kishita Y,Sakai N,Hamada Y,Kamagata K,Kohda M,Ohtake A,Murayama K,Okazaki Y
459140 was used in Western Blotting to describe a case with infantile-onset neurodegeneration, psychomotor retardation, irritability, hypotonia, and nystagmus.
Mon Nov 09 00:00:00 UTC 2020
Leigh Syndrome Due to NDUFV1 Mutations Initially Presenting as LBSL.
Genes
Borna NN,Kishita Y,Sakai N,Hamada Y,Kamagata K,Kohda M,Ohtake A,Murayama K,Okazaki Y
459140 was used in Western Blotting to describe a case with infantile-onset neurodegeneration, psychomotor retardation, irritability, hypotonia, and nystagmus.
Mon Nov 09 00:00:00 UTC 2020
Loss of MTX2 causes mandibuloacral dysplasia and links mitochondrial dysfunction to altered nuclear morphology.
Nature communications
Elouej S,Harhouri K,Le Mao M,Baujat G,Nampoothiri S,Kayserili H,Menabawy NA,Selim L,Paneque AL,Kubisch C,Lessel D,Rubinsztajn R,Charar C,Bartoli C,Airault C,Deleuze JF,Rötig A,Bauer P,Pereira C,Loh A,Escande-Beillard N,Muchir A,Martino L,Gruenbaum Y,Lee SH,Manivet P,Lenaers G,Reversade B,Lévy N,De Sandre-Giovannoli A
459140 was used in Western Blotting to report five homozygous null mutations in MTX2.
Fri Sep 11 00:00:00 UTC 2020
Loss of MTX2 causes mandibuloacral dysplasia and links mitochondrial dysfunction to altered nuclear morphology.
Nature communications
Elouej S,Harhouri K,Le Mao M,Baujat G,Nampoothiri S,Kayserili H,Menabawy NA,Selim L,Paneque AL,Kubisch C,Lessel D,Rubinsztajn R,Charar C,Bartoli C,Airault C,Deleuze JF,Rötig A,Bauer P,Pereira C,Loh A,Escande-Beillard N,Muchir A,Martino L,Gruenbaum Y,Lee SH,Manivet P,Lenaers G,Reversade B,Lévy N,De Sandre-Giovannoli A
459140 was used in Western Blotting to report five homozygous null mutations in MTX2.
Fri Sep 11 00:00:00 UTC 2020
A homozygous variant in NDUFA8 is associated with developmental delay, microcephaly, and epilepsy due to mitochondrial complex I deficiency.
Clinical genetics
Yatsuka Y,Kishita Y,Formosa LE,Shimura M,Nozaki F,Fujii T,Nitta KR,Ohtake A,Murayama K,Ryan MT,Okazaki Y
459140 was used in Western Blotting to report that the loss of NDUFA8, which has not previously been associated with mitochondrial disease, causes severe defect in the assembly of mitochondrial complex I, leading to progressive neurological and developmental abnormalities.
Sat Aug 01 00:00:00 UTC 2020
Age-dependent loss of adipose Rubicon promotes metabolic disorders via excess autophagy.
Nature communications
Yamamuro T,Kawabata T,Fukuhara A,Saita S,Nakamura S,Takeshita H,Fujiwara M,Enokidani Y,Yoshida G,Tabata K,Hamasaki M,Kuma A,Yamamoto K,Shimomura I,Yoshimori T
459140 was used in Western Blotting to propose that age-dependent decline in adipose Rubicon exacerbates metabolic disorders by promoting excess autophagic degradation of SRC-1 and TIF2.
Tue Aug 18 00:00:00 UTC 2020
The mitochondrial protein PGAM5 suppresses energy consumption in brown adipocytes by repressing expression of uncoupling protein 1.
The Journal of biological chemistry
Sugawara S,Kanamaru Y,Sekine S,Maekawa L,Takahashi A,Yamamoto T,Watanabe K,Fujisawa T,Hattori K,Ichijo H
459140 was used in Western Blotting to investigate the function of PGAM5 in brown adipose tissue using mouse models.
Fri Apr 24 00:00:00 UTC 2020
A novel homozygous variant in MICOS13/QIL1 causes hepato-encephalopathy with mitochondrial DNA depletion syndrome.
Molecular genetics & genomic medicine
Kishita Y,Shimura M,Kohda M,Akita M,Imai-Okazaki A,Yatsuka Y,Nakajima Y,Ito T,Ohtake A,Murayama K,Okazaki Y
459140 was used in Western Blotting to determine the clinical significance of the identified variant.
Thu Oct 01 00:00:00 UTC 2020
Dissecting the Roles of Mitochondrial Complex I Intermediate Assembly Complex Factors in the Biogenesis of Complex I.
Cell reports
Formosa LE,Muellner-Wong L,Reljic B,Sharpe AJ,Jackson TD,Beilharz TH,Stojanovski D,Lazarou M,Stroud DA,Ryan MT
459140 was used in Western Blotting to provide new functional insights into the essential nature of the MCIA complex in complex I assembly.
Tue Apr 21 00:00:00 UTC 2020
β-adrenergic receptor signaling evokes the PKA-ASK axis in mature brown adipocytes.
PloS one
Hattori K,Wakatsuki H,Sakauchi C,Furutani S,Sugawara S,Hatta T,Natsume T,Ichijo H
459140 was used in Western Blotting to identify the ASK family as a crucial signaling molecule bridging PKA and MAPK in mature brown adipocytes.
Thu Nov 12 00:00:00 UTC 2020
Mitochondrial Dysfunction Leads to Cortical Under-Connectivity and Cognitive Impairment.
Neuron
Fernandez A,Meechan DW,Karpinski BA,Paronett EM,Bryan CA,Rutz HL,Radin EA,Lubin N,Bonner ER,Popratiloff A,Rothblat LA,Maynard TM,LaMantia AS
459140 was used in Immunocytochemistry to assess cellular, molecular, and developmental origins of under-connectivity and its consequences for cognitive function.
Wed Jun 19 00:00:00 UTC 2019
Effects of prolonged type 2 diabetes on mitochondrial function in cerebral blood vessels.
American journal of physiology. Heart and circulatory physiology
Merdzo I,Rutkai I,Sure VNLR,Katakam PVG,Busija DW
459140 was used in Western Blotting to characterise the dynamics of mitochondrial function during the progression of type 2 diabetes mellitus with regard to mitochondrial respiration, protein expression, and reactive oxygen species production.
Fri Nov 01 00:00:00 UTC 2019
Stress-induced phospho-ubiquitin formation causes parkin degradation.
Scientific reports
Kovalchuke L,Mosharov EV,Levy OA,Greene LA
Published figure using UQCRC1 monoclonal antibody (Product # 459140) in Western Blot
Mon Aug 12 00:00:00 UTC 2019
COX6A2 variants cause a muscle-specific cytochrome c oxidase deficiency.
Annals of neurology
Inoue M,Uchino S,Iida A,Noguchi S,Hayashi S,Takahashi T,Fujii K,Komaki H,Takeshita E,Nonaka I,Okada Y,Yoshizawa T,Van Lommel L,Schuit F,Goto YI,Mimaki M,Nishino I
459140 was used in Blue native polyacrylamide gel electrophoresis to indicate that biallelic variants in COX6A2 cause a striated muscle-specific form of COX deficiency.
Thu Aug 01 00:00:00 UTC 2019
L-Arabinose Elicits Gut-Derived Hydrogen Production and Ameliorates Metabolic Syndrome in C57BL/6J Mice on High-Fat-Diet.
Nutrients
Zhao L,Wang Y,Zhang G,Zhang T,Lou J,Liu J
459140 was used in Western Blot to show oral L-arabinose elicited immediate and robust release of hydrogen in mice in a dose-and-time-dependent manner while alleviating high-fat-diet induced metabolic syndrome.
Fri Dec 13 00:00:00 UTC 2019
CLPP deficiency protects against metabolic syndrome but hinders adaptive thermogenesis.
EMBO reports
Becker C,Kukat A,Szczepanowska K,Hermans S,Senft K,Brandscheid CP,Maiti P,Trifunovic A
459140 was used in Western Blotting to establish that loss of the mitochondrial matrix protease CLPP results in a lean phenotype with improved glucose homeostasis.
Tue May 01 00:00:00 UTC 2018
Defects in the mitochondrial-tRNA modification enzymes MTO1 and GTPBP3 promote different metabolic reprogramming through a HIF-PPARγ-UCP2-AMPK axis.
Scientific reports
Boutoual R,Meseguer S,Villarroya M,Martín-Hernández E,Errami M,Martín MA,Casado M,Armengod ME
Published figure using UQCRC1 monoclonal antibody (Product # 459140) in Western Blot
Thu Jan 18 00:00:00 UTC 2018
Induction of PINK1/Parkin-Mediated Mitophagy.
Methods in molecular biology (Clifton, N.J.)
Sato S,Furuya N
459140 was used in Immunohistochemistry, Flow Cytometry, Immunocytochemistry, Western Blot to describe the methods for induction of PINK1/Parkin-mediated mitophagy in tissue culture cell lines.
Wed Jan 23 00:00:00 UTC 2019
Induction of PINK1/Parkin-Mediated Mitophagy.
Methods in molecular biology (Clifton, N.J.)
Sato S,Furuya N
459140 was used in Immunohistochemistry, Flow Cytometry, Immunocytochemistry, Western Blot to describe the methods for induction of PINK1/Parkin-mediated mitophagy in tissue culture cell lines.
Wed Jan 23 00:00:00 UTC 2019
APP promotes osteoblast survival and bone formation by regulating mitochondrial function and preventing oxidative stress.
Cell death & disease
Pan JX,Tang F,Xiong F,Xiong L,Zeng P,Wang B,Zhao K,Guo H,Shun C,Xia WF,Mei L,Xiong WC
459140 was used in Western Blot to identify the function of amyloid precursor protein (APP) in promoting osteoblast survival and bone formation.
Mon Oct 22 00:00:00 UTC 2018
Mild Impairment of Mitochondrial OXPHOS Promotes Fatty Acid Utilization in POMC Neurons and Improves Glucose Homeostasis in Obesity.
Cell reports
Timper K,Paeger L,Sánchez-Lasheras C,Varela L,Jais A,Nolte H,Vogt MC,Hausen AC,Heilinger C,Evers N,Pospisilik JA,Penninger JM,Taylor EB,Horvath TL,Kloppenburg P,Brüning JC
459140 was used in Western Blotting to show partial impairment of mitochondrial function shifts substrate utilization of POMC neurons from glucose to fatty acid metabolism and restores their firing properties, resulting in improved systemic glucose and energy metabolism in obesity.
Tue Oct 09 00:00:00 UTC 2018
Selective Disruption of Respiratory Supercomplexes as a New Strategy to Suppress Her2high Breast Cancer.
Antioxidants & redox signaling
Rohlenova K,Sachaphibulkij K,Stursa J,Bezawork-Geleta A,Blecha J,Endaya B,Werner L,Cerny J,Zobalova R,Goodwin J,Spacek T,Alizadeh Pesdar E,Yan B,Nguyen MN,Vondrusova M,Sobol M,Jezek P,Hozak P,Truksa J,Rohlena J,Dong LF,Neuzil J
459140 was used in western blot to test if electron transport chain disruption eliminates Her2-high disease
Tue Jan 10 00:00:00 UTC 2017
Impaired Mitochondrial Respiration in Large Cerebral Arteries of Rats with Type 2 Diabetes.
Journal of vascular research
Merdzo I,Rutkai I,Sure VN,McNulty CA,Katakam PV,Busija DW
459140 was used in western blot to evaluate the mitochondrial dynamics of the cerebral vasculature of 14-week-old Zucker diabetic fatty obese rats with early type 2 diabetes
Tue May 09 00:00:00 UTC 2017
Accessory subunits are integral for assembly and function of human mitochondrial complex I.
Nature
Stroud DA,Surgenor EE,Formosa LE,Reljic B,Frazier AE,Dibley MG,Osellame LD,Stait T,Beilharz TH,Thorburn DR,Salim A,Ryan MT
459140 was used in western blot to investigate the role of Complex I accessory subunits
Thu Oct 06 00:00:00 UTC 2016
Control of mitochondrial function and cell growth by the atypical cadherin Fat1.
Nature
Cao LL,Riascos-Bernal DF,Chinnasamy P,Dunaway CM,Hou R,Pujato MA,O'Rourke BP,Miskolci V,Guo L,Hodgson L,Fiser A,Sibinga NE
459140 was used in western blot to demonstrate that Fat1 cadherin represses mitochondrial respiration that regulates vascular smooth muscle cell proliferation after arterial injury
Thu Nov 24 00:00:00 UTC 2016
CHCHD10 mutations promote loss of mitochondrial cristae junctions with impaired mitochondrial genome maintenance and inhibition of apoptosis.
EMBO molecular medicine
Genin EC,Plutino M,Bannwarth S,Villa E,Cisneros-Barroso E,Roy M,Ortega-Vila B,Fragaki K,Lespinasse F,Pinero-Martos E,Augé G,Moore D,Burté F,Lacas-Gervais S,Kageyama Y,Itoh K,Yu-Wai-Man P,Sesaki H,Ricci JE,Vives-Bauza C,Paquis-Flucklinger V
Published figure using UQCRC1 monoclonal antibody (Product # 459140) in Western Blot
Fri Jan 01 00:00:00 UTC 2016
Loss of CLPP alleviates mitochondrial cardiomyopathy without affecting the mammalian UPRmt.
EMBO reports
Seiferling D,Szczepanowska K,Becker C,Senft K,Hermans S,Maiti P,König T,Kukat A,Trifunovic A
Published figure using UQCRC1 monoclonal antibody (Product # 459140) in Western Blot
Fri Jul 01 00:00:00 UTC 2016
The mitochondrial function of the cerebral vasculature in insulin-resistant Zucker obese rats.
American journal of physiology. Heart and circulatory physiology
Merdzo I,Rutkai I,Tokes T,Sure VN,Katakam PV,Busija DW
459140 was used in western blot to study cerebral vasculature mitochondrial function in insulin-resistant Zucker obese rats
Fri Apr 01 00:00:00 UTC 2016
ASK1 signalling regulates brown and beige adipocyte function.
Nature communications
Hattori K,Naguro I,Okabe K,Funatsu T,Furutani S,Takeda K,Ichijo H
459140 was used in western blot to elucidate regulation of brown and beige adipocyte function via ASK1 signaling
Tue Apr 05 00:00:00 UTC 2016
MicroRNA-181a suppresses parkin-mediated mitophagy and sensitizes neuroblastoma cells to mitochondrial uncoupler-induced apoptosis.
Oncotarget
Cheng M,Liu L,Lao Y,Liao W,Liao M,Luo X,Wu J,Xie W,Zhang Y,Xu N
459140 was used in western blot to demonstrate that miR-181a inhibits mitophagy
Tue Jul 05 00:00:00 UTC 2016
Dynamics of enhanced mitochondrial respiration in female compared with male rat cerebral arteries.
American journal of physiology. Heart and circulatory physiology
Rutkai I,Dutta S,Katakam PV,Busija DW
459140 was used in western blot to test if mitochondrial energetics of large cerebral arteries are sex dependent.
Sun Nov 01 00:00:00 UTC 2015
Defective Expression of the Mitochondrial-tRNA Modifying Enzyme GTPBP3 Triggers AMPK-Mediated Adaptive Responses Involving Complex I Assembly Factors, Uncoupling Protein 2, and the Mitochondrial Pyruvate Carrier.
PloS one
Martínez-Zamora A,Meseguer S,Esteve JM,Villarroya M,Aguado C,Enríquez JA,Knecht E,Armengod ME
459140 was used in western blot to analyze GTPBP3 defective expression in AMPK-mediated responses
Mon Jun 27 00:00:00 UTC 2016
AMP-activated protein kinase controls exercise training- and AICAR-induced increases in SIRT3 and MnSOD.
Frontiers in physiology
Brandauer J,Andersen MA,Kellezi H,Risis S,Frøsig C,Vienberg SG,Treebak JT
459140 was used in western blot to test the requirement of AMP-activated protein kinase for exercise training-induced increases in skeletal muscle abundance of mitochondrial proteins.
Wed Apr 08 00:00:00 UTC 2015
Targeting FoxO1 with AS1842856 suppresses adipogenesis.
Cell cycle (Georgetown, Tex.)
Zou P,Liu L,Zheng L,Liu L,Stoneman RE,Cho A,Emery A,Gilbert ER,Cheng Z
459140 was used in western blot to investigate the role of FoxO1 during adipocyte differentiation and adipogenesis
Thu Sep 10 00:00:00 UTC 2015
Deregulation of mitochondria-shaping proteins Opa-1 and Drp-1 in manganese-induced apoptosis.
PloS one
Alaimo A,Gorojod RM,Beauquis J,Muñoz MJ,Saravia F,Kotler ML
459140 was used in western blot to investigate the role of mitochondria in manganese-induced Parkinsonism
Tue Nov 18 00:00:00 UTC 2014
IKKα and alternative NF-κB regulate PGC-1β to promote oxidative muscle metabolism.
The Journal of cell biology
Bakkar N,Ladner K,Canan BD,Liyanarachchi S,Bal NC,Pant M,Periasamy M,Li Q,Janssen PM,Guttridge DC
459140 was used in western blot to study NF-κB signaling during in lymphoid development.
Mon Feb 20 00:00:00 UTC 2012
The extrinsic and intrinsic apoptotic pathways are involved in manganese toxicity in rat astrocytoma C6 cells.
Neurochemistry international
Alaimo A,Gorojod RM,Kotler ML
459140 was used in western blot to investigate the molecular mechanisms involved in manganese neurotoxicity
Mon Aug 01 00:00:00 UTC 2011
Mitochondrial DNA toxicity compromises mitochondrial dynamics and induces hippocampal antioxidant defenses.
DNA repair
Lauritzen KH,Cheng C,Wiksen H,Bergersen LH,Klungland A
459140 was used in immunohistochemistry - paraffin section to investigate the effects of mitochondrial DNA damage on hippocampal neurons.
Fri Jun 10 00:00:00 UTC 2011
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.jpg?time=20250104?time=20250104 "UQCRC1 Antibody (459140) in WB")
