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Sequence of this protein is as follows: MKVLLLKDAK EDDCGQDPYI RELGLYGLEA TLIPVLSFEF LSLPSFSEKL SHPEDYGGLI FTSPRAVEAA ELCLEQNNKT EVWERSLKEK WNAKSVYVVG NATASLVSKI GLDTEGETCG NAEKLAEYIC SRESSALPLL FPCGNLKREI LPKALKDKGI AMESITVYQT VAHPGIQGNL NSYYSQQGVP ASITFFSPSG LTYSLKHIQE LSGDNIDQIK FAAIGPTTAR ALAAQGLPVS CTAESPTPQA LATGIRKALQ PHGCC
The protein encoded by this gene catalyzes the fourth step of porphyrin biosynthesis in the heme biosynthetic pathway. Defects in this gene cause congenital erythropoietic porphyria (Gunther's disease).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: hydroxymethylbilane hydrolyase; Hydroxymethylbilane hydrolyase [cyclizing]; UROIIIS; Uroporphyrinogen-III cosynthase; Uroporphyrinogen-III synthase
Gene Aliases: AI415298; UROIIIS; UROS; Uros3
UniProt ID: (Human) P10746, (Mouse) P51163
Entrez Gene ID: (Human) 7390, (Mouse) 22276
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