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USP10 Polyclonal Antibody

USP10 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 7

USP10 Antibody (19374-1-AP) in ICC/IF

Immunofluorescent analysis of Hela cells, using USP10 antibody 19374-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IGG (red).

USP10 Antibody in Immunoprecipitation (IP)

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Product Details

19374-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:3,000

View 5 publications 5 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

1:10-1:100

View 3 publications 3 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

USP10 Fusion Protein Ag7233 (444-798 aa encoded by BC000263)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.19 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: KFIPLYSKV QRPCTSTPMI DSFVRLMNEF TNMPVPPKPR QALGDKIVRD IRPGAAFEPT YIYRLLTVNK SSLSEKGRQE DAEEYLGFIL NGLHEEMLNL KKLLSPSNEK LTISNGPKNH SVNEEEQEEQ GEGSEDEWEQ VGPRNKTSVT RQADFVQTPI TGIFGGHIRS VVYQQSSKES ATLQPFFTLQ LDIQSDKIRT VQDALESLVA RESVQGYTTK TKQEVEISRR VTLEKLPPVL VLHLKRFVYE KTGGCQKLIK NIEYPVDLEI SKELLSPGVK NKNFKCHRTY RLFAVVYHHG NSATGGHYTT DVFQIGLNGW LRIDDQTVKV INQYQVVKPT AERTAYLLYY RRVDLL (444-798 aa encoded by BC000263)

Target Information

USP10, also known as ubiquitin specific peptidase 10, belongs to the ubiquitin-specific protease family of cysteine proteases. USP10 functions to catalyze the cleavage of ubiquitin from ubiquitin-conjugated protein substrates such as p53/TP53, SNX3 and CFTR. USP10 has been identified as a subunit of DNA-bound androgen receptor (AR) complexes and may play a role in the activity of the DNA-bound androgen receptor complex. USP10 also acts as an essential regulator of p53/TP53 stability and is thought to function as a tumor suppressor.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

Cell death and differentiation

Cao YF,Xie L,Tong BB,Chu MY,Shi WQ,Li X,He JZ,Wang SH,Wu ZY,Deng DX,Zheng YQ,Li ZM,Xu XE,Liao LD,Cheng YW,Li LY,Xu LY,Li EM

Wed Feb 01 00:00:00 UTC 2023

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

Cell death and differentiation

Cao YF,Xie L,Tong BB,Chu MY,Shi WQ,Li X,He JZ,Wang SH,Wu ZY,Deng DX,Zheng YQ,Li ZM,Xu XE,Liao LD,Cheng YW,Li LY,Xu LY,Li EM

Wed Feb 01 00:00:00 UTC 2023

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

Cell death and differentiation

Cao YF,Xie L,Tong BB,Chu MY,Shi WQ,Li X,He JZ,Wang SH,Wu ZY,Deng DX,Zheng YQ,Li ZM,Xu XE,Liao LD,Cheng YW,Li LY,Xu LY,Li EM

Wed Feb 01 00:00:00 UTC 2023

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

Cell death and differentiation

Cao YF,Xie L,Tong BB,Chu MY,Shi WQ,Li X,He JZ,Wang SH,Wu ZY,Deng DX,Zheng YQ,Li ZM,Xu XE,Liao LD,Cheng YW,Li LY,Xu LY,Li EM

Wed Feb 01 00:00:00 UTC 2023

Limonin stabilises sirtuin 6 (SIRT6) by activating ubiquitin specific peptidase 10 (USP10) in cardiac hypertrophy.

British journal of pharmacology

Liu LB,Huang SH,Qiu HL,Cen XF,Guo YY,Li D,Ma YL,Xu M,Tang QZ

Thu Sep 01 00:00:00 UTC 2022

High-fidelity reconstitution of stress granules and nucleoli in mammalian cellular lysate.

The Journal of cell biology

Freibaum BD,Messing J,Yang P,Kim HJ,Taylor JP

Mon Mar 01 00:00:00 UTC 2021

Isoquercitrin protects HUVECs against high glucose‑induced apoptosis through regulating p53 proteasomal degradation.

International journal of molecular medicine

Liu L,Huang S,Xu M,Gong Y,Li D,Wan C,Wu H,Tang Q

Thu Jul 01 00:00:00 UTC 2021

Isoquercitrin protects HUVECs against high glucose‑induced apoptosis through regulating p53 proteasomal degradation.

International journal of molecular medicine

Liu L,Huang S,Xu M,Gong Y,Li D,Wan C,Wu H,Tang Q

Thu Jul 01 00:00:00 UTC 2021

Targeting USP47 overcomes tyrosine kinase inhibitor resistance and eradicates leukemia stem/progenitor cells in chronic myelogenous leukemia.

Nature communications

Lei H,Xu HZ,Shan HZ,Liu M,Lu Y,Fang ZX,Jin J,Jing B,Xiao XH,Gao SM,Gao FH,Xia L,Yang L,Liu LG,Wang WW,Liu CX,Tong Y,Wu YZ,Zheng JK,Chen GQ,Zhou L,Wu YL

Mon Jan 04 00:00:00 UTC 2021

G3BP1 Is a Tunable Switch that Triggers Phase Separation to Assemble Stress Granules.

Cell

Yang P,Mathieu C,Kolaitis RM,Zhang P,Messing J,Yurtsever U,Yang Z,Wu J,Li Y,Pan Q,Yu J,Martin EW,Mittag T,Kim HJ,Taylor JP

Thu Apr 16 00:00:00 UTC 2020

Translational Repression of G3BP in Cancer and Germ Cells Suppresses Stress Granules and Enhances Stress Tolerance.

Molecular cell

Lee AK,Klein J,Fon Tacer K,Lord T,Oatley MJ,Oatley JM,Porter SN,Pruett-Miller SM,Tikhonova EB,Karamyshev AL,Wang YD,Yang P,Korff A,Kim HJ,Taylor JP,Potts PR

Thu Aug 20 00:00:00 UTC 2020

Bioinformatics

Protein Aliases: Deubiquitinating enzyme 10; MGC2621; ubiquintin c-terminal hydrolase related polypeptide; Ubiquitin carboxyl-terminal hydrolase 10; ubiquitin specific protease 10; Ubiquitin thioesterase 10; ubiquitin thiolesterase 10; Ubiquitin-specific-processing protease 10

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Gene Aliases: 2610014N07Rik; KIAA0190; mKIAA0190; Ode-1; UBPO; Uchrp; USP10

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UniProt ID: (Human) Q14694, (Mouse) P52479, (Rat) Q3KR59

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Entrez Gene ID: (Human) 9100, (Mouse) 22224, (Rat) 307905

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Function(s)

p53 binding cysteine-type endopeptidase activity thiol-dependent ubiquitin-specific protease activity protein binding ion channel binding poly(A) RNA binding peptidase activity cysteine-type peptidase activity hydrolase activity thiol-dependent ubiquitinyl hydrolase activity

Process(es)

DNA repair proteolysis ubiquitin-dependent protein catabolic process autophagy cellular response to DNA damage stimulus regulation of autophagy protein deubiquitination DNA damage response, signal transduction by p53 class mediator proteasome-mediated ubiquitin-dependent protein catabolic process regulation of proteasomal protein catabolic process translesion synthesis negative regulation of I-kappaB kinase/NF-kappaB signaling cellular response to interleukin-1

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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USP10 Polyclonal Antibody

USP10 Antibody (19374-1-AP) in ICC/IF

Product Details

19374-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Not applicable (N/A)

Species Reactivity

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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