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USP10 Antibody (MA5-25796) in IHC (P)
Immunohistochemistry was performed on paraffin-embedded carcinoma of human bladder tissue. To expose target proteins, 10mM citric buffer, pH6.0, 100°C for 10min was used. Following antigen retrieval, tissues were probed with a USP10 monoclonal antibody (Product # MA5-25796).
Product Details
MA5-25796
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Non-human primate
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
OTI1H9
Immunogen
Full length human recombinant protein of USP10 produced in HEK293T cell
Conjugate
Form
Liquid
Concentration
0.74 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2725634
Target Information
USP10, also known as ubiquitin specific peptidase 10, belongs to the ubiquitin-specific protease family of cysteine proteases. USP10 functions to catalyze the cleavage of ubiquitin from ubiquitin-conjugated protein substrates such as p53/TP53, SNX3 and CFTR. USP10 has been identified as a subunit of DNA-bound androgen receptor (AR) complexes and may play a role in the activity of the DNA-bound androgen receptor complex. USP10 also acts as an essential regulator of p53/TP53 stability and is thought to function as a tumor suppressor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Deubiquitinating enzyme 10; MGC2621; Ubiquitin carboxyl-terminal hydrolase 10; ubiquitin specific protease 10; Ubiquitin thioesterase 10; ubiquitin thiolesterase 10; Ubiquitin-specific-processing protease 10
Gene Aliases: KIAA0190; UBPO; USP10
UniProt ID: (Human) Q14694
Entrez Gene ID: (Human) 9100
ubiquitin-dependent protein catabolic process
autophagy
cellular response to DNA damage stimulus
regulation of autophagy
protein deubiquitination
translesion synthesis
DNA damage response, signal transduction by p53 class mediator
negative regulation of I-kappaB kinase/NF-kappaB signaling
cellular response to interleukin-1
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