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USP11 Polyclonal Antibody

USP11 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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USP11 Antibody (10244-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human colon cancer tissue slide using 10244-1-AP ( USP11 Antibody) at dilution of 1:200 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

USP11 Antibody in Immunoprecipitation (IP)

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Product Details

10244-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 8 publications 8 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

USP11 Fusion Protein Ag0296 (55-567 aa encoded by BC000350)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.13 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: RAGESWFLV EKHWYKQWEA YVQGGDQDSS TFPGCINNAT LFQDEINWRL KEGLVEGEDY VLLPAAAWHY LVSWYGLEHG QPPIERKVIE LPNIQKVEVY PVELLLVRHN DLGKSHTVQF SHTDSIGLVL RTARERFLVE PQEDTRLWAK NSEGSLDRLY DTHITVLDAA LETGQLIIME TRKKDGTWPS AQLHVMNNNM SEEDEDFKGQ PGICGLTNLG NTCFMNSALQ CLSNVPQLTE YFLNNCYLEE LNFRNPLGMK GEIAEAYADL VKQAWSGHHR SIVPHVFKNK VGHFASQFLG YQQHDSQELL SFLLDGLHED LNRVKKKEYV ELCDAAGRPD QEVAQEAWQN HKRRNDSVIV DTFHGLFKST LVCPDCGNVS VTFDPFCYLS VPLLISHKRV LEVFFIPMDP RRKPEQHRLV VPKKGKISDL CVALSKHTGI SPERMMVADV FSHRFYKLYQ LEEPLSSILD RDDIFVYEVS GRIEAIEGSR EDIVVPVYLR ERTPARDYNN SYYG (55-567 aa encoded by BC000350)

Target Information

USP11 (ubiquitin specific peptidase 11), also known as UHX1, is a 920 amino acid deubiquitinating enzyme that participates in the Ub pathway. Localized to the nucleus, USP11 associates with both Ran BP-M (Ran binding protein M) and with the tumor suppressor BRCA2. Through these associations, USP11 functions to either inhibit ubiquitination of these proteins or to remove ubiquitin residues that have already been attached to these proteins. USP11 is implicated in several X-linked retinal diseases and, due to its ability to deubiquitinate BRCA2, may play a role in tumor suppression.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

XRCC1 protects transcription from toxic PARP1 activity during DNA base excision repair.

Nature cell biology

Adamowicz M,Hailstone R,Demin AA,Komulainen E,Hanzlikova H,Brazina J,Gautam A,Wells SE,Caldecott KW

Wed Dec 01 00:00:00 UTC 2021

The E2F1/USP11 positive feedback loop promotes hepatocellular carcinoma metastasis and inhibits autophagy by activating ERK/mTOR pathway.

Cancer letters

Qiao L,Zhang Q,Sun Z,Liu Q,Wu Z,Hu W,Bao S,Yang Q,Liu L

Sat Aug 28 00:00:00 UTC 2021

The E2F1/USP11 positive feedback loop promotes hepatocellular carcinoma metastasis and inhibits autophagy by activating ERK/mTOR pathway.

Cancer letters

Qiao L,Zhang Q,Sun Z,Liu Q,Wu Z,Hu W,Bao S,Yang Q,Liu L

Sat Aug 28 00:00:00 UTC 2021

The deubiquitinase USP11 regulates cell proliferation and ferroptotic cell death via stabilization of NRF2 USP11 deubiquitinates and stabilizes NRF2.

Oncogene

Meng C,Zhan J,Chen D,Shao G,Zhang H,Gu W,Luo J

Mon Mar 01 00:00:00 UTC 2021

A feedforward circuit shaped by ECT2 and USP7 contributes to breast carcinogenesis.

Theranostics

Zhang Q,Cao C,Gong W,Bao K,Wang Q,Wang Y,Bi L,Ma S,Zhao J,Liu L,Tian S,Zhang K,Yang J,Yao Z,Song N,Shi L

Mon May 31 00:00:00 UTC 2021

Aberrant USP11 expression regulates NF90 to promote proliferation and metastasis in hepatocellular carcinoma.

American journal of cancer research

Zhang C,Xie C,Wang X,Huang Y,Gao S,Lu J,Lu Y,Zhang S

Mon Sep 28 00:00:00 UTC 2020

Aberrant USP11 expression regulates NF90 to promote proliferation and metastasis in hepatocellular carcinoma.

American journal of cancer research

Zhang C,Xie C,Wang X,Huang Y,Gao S,Lu J,Lu Y,Zhang S

Mon Sep 28 00:00:00 UTC 2020

EGFR-vIII downregulated H2AZK4/7AC though the PI3K/AKT-HDAC2 axis to regulate cell cycle progression.

Clinical and translational medicine

Zhao H,Wang Y,Yang C,Zhou J,Wang L,Yi K,Li Y,Wang Q,Shi J,Kang C,Zeng L

Tue Jan 28 00:00:00 UTC 2020

EGFR-vIII downregulated H2AZK4/7AC though the PI3K/AKT-HDAC2 axis to regulate cell cycle progression.

Clinical and translational medicine

Zhao H,Wang Y,Yang C,Zhou J,Wang L,Yi K,Li Y,Wang Q,Shi J,Kang C,Zeng L

Tue Jan 28 00:00:00 UTC 2020

CRL4^DCAF8 and USP11 oppositely regulate the stability of myeloid leukemia factors (MLFs).

Biochemical and biophysical research communications

Huang D,Liu C,Sun X,Sun X,Qu Y,Tang Y,Li G,Tong T

Thu Aug 20 00:00:00 UTC 2020

Ubiquitin-specific protease 11 (USP11) functions as a tumor suppressor through deubiquitinating and stabilizing VGLL4 protein.

American journal of cancer research

Zhang E,Shen B,Mu X,Qin Y,Zhang F,Liu Y,Xiao J,Zhang P,Wang C,Tan M,Fan Y

Thu Oct 01 00:00:00 UTC 2020

Ubiquitin-specific protease 11 (USP11) functions as a tumor suppressor through deubiquitinating and stabilizing VGLL4 protein.

American journal of cancer research

Zhang E,Shen B,Mu X,Qin Y,Zhang F,Liu Y,Xiao J,Zhang P,Wang C,Tan M,Fan Y

Thu Oct 01 00:00:00 UTC 2020

Ubiquitin-specific protease 11 functions as a tumor suppressor by modulating Mgl-1 protein to regulate cancer cell growth.

Oncotarget

Lim KH,Suresh B,Park JH,Kim YS,Ramakrishna S,Baek KH

Tue Mar 22 00:00:00 UTC 2016

Ubiquitin-specific protease 11 functions as a tumor suppressor by modulating Mgl-1 protein to regulate cancer cell growth.

Oncotarget

Lim KH,Suresh B,Park JH,Kim YS,Ramakrishna S,Baek KH

Tue Mar 22 00:00:00 UTC 2016

Bioinformatics

Protein Aliases: deubiquitinating enzyme 11; RP4-659F15.2; ubiquitin carboxyl-terminal hydrolase, X-linked; ubiquitin thioesterase 11; ubiquitin thiolesterase 11; ubiquitin-specific processing protease 11; ubiquitin-specific-processing protease 11

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Gene Aliases: UHX1

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Entrez Gene ID: (Human) 8237

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Function(s)

cysteine-type endopeptidase activity thiol-dependent ubiquitin-specific protease activity protein binding

Process(es)

ubiquitin-dependent protein catabolic process protein deubiquitination

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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USP11 Polyclonal Antibody

USP11 Antibody (10244-1-AP) in IHC (P)

Product Details

10244-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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