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Invitrogen
USP21 Polyclonal Antibody
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USP21 Antibody (PA5-116440) in IHC (P)
Immunohistochemical analysis of USP21 in a paraffin-embedded human fetal skeletal muscle tissue using a USP21 polyclonal antibody (Product #PA5-116440). The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 8.0-8.4) for 20 minutes. The tissues were blocked in 5% BSA for 30 minutes at room temperature, washed with ddH2O and PBS, and then probed with the primary antibody ... View More
Product Details
PA5-116440
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein within Human USP21 aa 303-453
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol, 0.2% BSA
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2901072
Product Specific Information
Positive controls: SHSY5Y cell lysates, Rat kidney tissue, human fetal skeletal muscle tissue, Mouse heart tissue, SHSY5Y.
Target Information
This gene encodes a member of the C19 peptidase family, also known as family 2 of ubiquitin carboxy-terminal hydrolases. The encoded protein cleaves ubiquitin from ubiquitinated proteins for recycling in intracellular protein degradation. The encoded protein is also able to release NEDD8, a ubiquitin-like protein, from NEDD8-conjugated proteins. This gene has been referred to as USP16 and USP23 but is now known as USP21. Alternatively spliced transcript variants have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Deubiquitinating enzyme 21; NEDD8-specific protease; Ubiquitin carboxyl-terminal hydrolase 21; ubiquitin specific protease 21; ubiquitin specific protease 23; Ubiquitin thioesterase 21; ubiquitin thiolesterase 21; ubiquitin-specific processing protease 21; ubiquitin-specific protease 16; ubiquitin-specific protease 21; Ubiquitin-specific-processing protease 21
Gene Aliases: ESTM28; PP1490; USP16; USP21; USP23; W53272
UniProt ID: (Human) Q9UK80, (Mouse) Q9QZL6, (Rat) B2GUX4
Entrez Gene ID: (Human) 27005, (Mouse) 30941, (Rat) 688466
transcription coactivator activity
thiol-dependent ubiquitin-specific protease activity
protein binding
cysteine-type peptidase activity
NEDD8-specific protease activity
metal ion binding
cysteine-type endopeptidase activity
peptidase activity
hydrolase activity
thiol-dependent ubiquitinyl hydrolase activity
molecular_function
transcription, DNA-templated
regulation of transcription, DNA-templated
proteolysis
ubiquitin-dependent protein catabolic process
chromatin modification
histone deubiquitination
neuron projection development
proteasome-mediated ubiquitin-dependent protein catabolic process
positive regulation of transcription, DNA-templated
regulation of proteasomal protein catabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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