Proteintech

USP22 Polyclonal Antibody

USP22 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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USP22 Antibody (55110-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human lung cancer tissue slide using (Product # 55110-1-AP) (USP22 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

USP22 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

55110-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:6,000

View 10 publications 10 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

Assay-dependent

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 3 publications 3 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.77 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

USP22 has 2 isoforms with molecular mass of 58 kDa and 60 kDa. The antibody is specific to USP22.

Target Information

Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

USP22 upregulates ZEB1-mediated VEGFA transcription in hepatocellular carcinoma.

Cell death & disease

Zeng K,Xie W,Wang C,Wang S,Liu W,Su Y,Lin L,Zou R,Sun G,Zhou B,Wang M,Luan R,Bai Y,Huo Y,Kato S,Zhong X,Zhao Y

Sat Mar 11 00:00:00 UTC 2023

USP22 upregulates ZEB1-mediated VEGFA transcription in hepatocellular carcinoma.

Cell death & disease

Zeng K,Xie W,Wang C,Wang S,Liu W,Su Y,Lin L,Zou R,Sun G,Zhou B,Wang M,Luan R,Bai Y,Huo Y,Kato S,Zhong X,Zhao Y

Sat Mar 11 00:00:00 UTC 2023

USP22 aggravated diabetic renal tubulointerstitial fibrosis progression through deubiquitinating and stabilizing Snail1.

European journal of pharmacology

Zhao X,He X,Wei W,Huang K

Mon May 15 00:00:00 UTC 2023

USP22 aggravated diabetic renal tubulointerstitial fibrosis progression through deubiquitinating and stabilizing Snail1.

European journal of pharmacology

Zhao X,He X,Wei W,Huang K

Mon May 15 00:00:00 UTC 2023

USP22-mediated deubiquitination of PTEN inhibits pancreatic cancer progression by inducing p21 expression.

Molecular oncology

Ren D,Sun Y,Li D,Wu H,Jin X

Tue Mar 01 00:00:00 UTC 2022

USP22-mediated deubiquitination of PTEN inhibits pancreatic cancer progression by inducing p21 expression.

Molecular oncology

Ren D,Sun Y,Li D,Wu H,Jin X

Tue Mar 01 00:00:00 UTC 2022

Derepression of the USP22-FASN axis by p53 loss under oxidative stress drives lipogenesis and tumorigenesis.

Cell death discovery

Han Z,Liu M,Xie Y,Zeng K,Zhan Z,Chen Y,Wang L,Chen X,Luo Y,Zeng Y,Zhan H,Lin Y,Zhang K,Zhu X,Liu S,Luo X,Zhou A

Fri Nov 04 00:00:00 UTC 2022

Derepression of the USP22-FASN axis by p53 loss under oxidative stress drives lipogenesis and tumorigenesis.

Cell death discovery

Han Z,Liu M,Xie Y,Zeng K,Zhan Z,Chen Y,Wang L,Chen X,Luo Y,Zeng Y,Zhan H,Lin Y,Zhang K,Zhu X,Liu S,Luo X,Zhou A

Fri Nov 04 00:00:00 UTC 2022

Derepression of the USP22-FASN axis by p53 loss under oxidative stress drives lipogenesis and tumorigenesis.

Cell death discovery

Han Z,Liu M,Xie Y,Zeng K,Zhan Z,Chen Y,Wang L,Chen X,Luo Y,Zeng Y,Zhan H,Lin Y,Zhang K,Zhu X,Liu S,Luo X,Zhou A

Fri Nov 04 00:00:00 UTC 2022

Derepression of the USP22-FASN axis by p53 loss under oxidative stress drives lipogenesis and tumorigenesis.

Cell death discovery

Han Z,Liu M,Xie Y,Zeng K,Zhan Z,Chen Y,Wang L,Chen X,Luo Y,Zeng Y,Zhan H,Lin Y,Zhang K,Zhu X,Liu S,Luo X,Zhou A

Fri Nov 04 00:00:00 UTC 2022

Targeting USP22 with miR‑30‑5p to inhibit the hypoxia‑induced expression of PD‑L1 in lung adenocarcinoma cells.

Oncology reports

Hua X,Chu H,Wang C,Shi X,Wang A,Zhang Z

Fri Oct 01 00:00:00 UTC 2021

Targeting USP22 with miR‑30‑5p to inhibit the hypoxia‑induced expression of PD‑L1 in lung adenocarcinoma cells.

Oncology reports

Hua X,Chu H,Wang C,Shi X,Wang A,Zhang Z

Fri Oct 01 00:00:00 UTC 2021

The POU2F1/miR-4490/USP22 axis regulates cell proliferation and metastasis in gastric cancer.

Cellular oncology (Dordrecht, Netherlands)

Xiao Y,Liu S,Li J,Dai W,Tang W,Xiang L,Zhang W,Lin J,Wang J,Wu X,Liu G,Liu Y,Chen Y,Zhu H,Wang Y,Lin Z,Yang Q,Chen T,Sun Y,Li A,Xiong J,Wang J

Tue Dec 01 00:00:00 UTC 2020

ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP.

Nature communications

Bufalieri F,Infante P,Bernardi F,Caimano M,Romania P,Moretti M,Lospinoso Severini L,Talbot J,Melaiu O,Tanori M,Di Magno L,Bellavia D,Capalbo C,Puget S,De Smaele E,Canettieri G,Guardavaccaro D,Busino L,Peschiaroli A,Pazzaglia S,Giannini G,Melino G,Locatelli F,Gulino A,Ayrault O,Fruci D,Di Marcotullio L

Wed Jul 24 00:00:00 UTC 2019

Ubiquitin-specific protease 22 enhances intestinal cell proliferation and tissue regeneration after intestinal ischemia reperfusion injury.

World journal of gastroenterology

Ji AL,Li T,Zu G,Feng DC,Li Y,Wang GZ,Yao JH,Tian XF

Thu Feb 21 00:00:00 UTC 2019

Broad and diverse mechanisms used by deubiquitinase family members in regulating the type I interferon signaling pathway during antiviral responses.

Science advances

Liu Q,Wu Y,Qin Y,Hu J,Xie W,Qin FX,Cui J

Tue May 01 00:00:00 UTC 2018

Broad and diverse mechanisms used by deubiquitinase family members in regulating the type I interferon signaling pathway during antiviral responses.

Science advances

Liu Q,Wu Y,Qin Y,Hu J,Xie W,Qin FX,Cui J

Tue May 01 00:00:00 UTC 2018

AGEs-RAGE system down-regulates Sirt1 through the ubiquitin-proteasome pathway to promote FN and TGF-β1 expression in male rat glomerular mesangial cells.

Endocrinology

Huang KP,Chen C,Hao J,Huang JY,Liu PQ,Huang HQ

Thu Jan 01 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: Deubiquitinating enzyme 22; Ubiquitin carboxyl-terminal hydrolase 22; ubiquitin specific protease 22; Ubiquitin thioesterase 22; ubiquitin thiolesterase 22; ubiquitin-specific processing protease 22; Ubiquitin-specific-processing protease 22

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Gene Aliases: AI427806; KIAA1063; USP22; USP3L

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UniProt ID: (Human) Q9UPT9, (Mouse) Q5DU02

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Entrez Gene ID: (Human) 23326, (Mouse) 216825, (Rat) 303201

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Function(s)

transcription coactivator activity thiol-dependent ubiquitin-specific protease activity protein binding zinc ion binding H4 histone acetyltransferase activity enzyme binding ligand-dependent nuclear receptor transcription coactivator activity cysteine-type endopeptidase activity peptidase activity cysteine-type peptidase activity hydrolase activity thiol-dependent ubiquitinyl hydrolase activity metal ion binding molecular_function

Process(es)

transcription, DNA-templated regulation of transcription, DNA-templated proteolysis ubiquitin-dependent protein catabolic process cell cycle chromatin modification histone ubiquitination histone deubiquitination protein deubiquitination proteasome-mediated ubiquitin-dependent protein catabolic process histone H4 acetylation positive regulation of transcription, DNA-templated positive regulation of mitotic cell cycle regulation of proteasomal protein catabolic process biological_process embryo development

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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USP22 Polyclonal Antibody

USP22 Antibody (55110-1-AP) in IHC (P)

Product Details

55110-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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