Proteintech

USP37 Polyclonal Antibody

View all (8) USP37 antibodies

Questions & Answers

Questions & Answers

Antibody Testing Data (9)

USP37 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

USP37 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 9

USP37 Antibody (18465-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using (Product # 18465-1-AP) (USP37 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

USP37 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

USP37 Antibody in Western Blot (WB)

USP37 Antibody in Western Blot (WB)

USP37 Antibody in Western Blot (WB)

USP37 Antibody in Western Blot (WB)

USP37 Antibody in Western Blot (WB)

USP37 Antibody in Western Blot (WB)

USP37 Antibody in Western Blot (WB)

USP37 Antibody in Immunoprecipitation (IP)

Product Image Gallery

USP37 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemical analysis of paraffin-embedded human breast cancer tissue slide using (Product # 18465-1-AP) (USP37 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

USP37 Antibody in Western Blot (WB) — Mouse spleen tissue were subjected to SDS PAGE followed by western blot with 18465-1-AP (USP37 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

USP37 Antibody in Western Blot (WB) — Human brain tissue were subjected to SDS PAGE followed by western blot with 18465-1-AP (USP37 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

USP37 Antibody in Western Blot (WB) — Mouse brain tissue were subjected to SDS PAGE followed by western blot with 18465-1-AP (USP37 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours.

USP37 Antibody in Western Blot (WB) — Mouse brain tissue were subjected to SDS PAGE followed by western blot with 18465-1-AP (USP37 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

USP37 Antibody in Western Blot (WB) — HEK-293 cells were subjected to SDS PAGE followed by western blot with 18465-1-AP (USP37 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

USP37 Antibody in Western Blot (WB) — HepG2 cells were subjected to SDS PAGE followed by western blot with 18465-1-AP (USP37 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

USP37 Antibody in Western Blot (WB) — HeLa cells were subjected to SDS PAGE followed by western blot with 18465-1-AP (USP37 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

USP37 Antibody in Immunoprecipitation (IP) — IP result of anti-USP37 (IP:18465-1-AP, 4ug; Detection:18465-1-AP 1:500) with mouse brain tissue lysate 4000ug.

Product Details

18465-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 9 publications 9 publications

Immunohistochemistry (IHC)

Assay-dependent

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200

-

Immunocytochemistry (ICC/IF)

-

View 4 publications 4 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

USP37 Fusion Protein Ag12513 (1-351 aa encoded by BC112901)

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.13 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MLTLQDNSF LSIDKVPSKD AEEMRLFLDA VHQNRLPAAM KPSQGSGSFG AILGSRTSQK ETSRQLSYSD NQASAKRGSL ETKDDIPFRK VLGNPGRGSI KTVAGSGIAR TIPSLTSTST PLRSGLLENR TEKRKRMIST GSELNEDYPK ENDSSSNNKA MTDPSRKYLT SSREKQLSLK QSEENRTSGL LPLQSSSFYG SRAGSKEHSS GGTNLDRTNV SSQTPSAKRS LGFLPQPVPL SVKKLRCNQD YTGWNKPRVP LSSHQQQQLQ GFSNLGNTCY MNAILQSLFS LQSFANDLLK QGIPWKKIPL NALIRRFAHL LVKKDICNSE TKKDLLKKVK NAISATAERF SG (1-351 aa encoded by BC112901)

Target Information

Deubiquitinase that antagonizes the anaphase-promoting complex (APC/C) during G1/S transition by mediating deubiquitination of cyclin-A (CCNA1 and CCNA2), thereby promoting S phase entry. Specifically mediates deubiquitination of 'Lys-11'-linked polyubiquitin chains, a specific ubiquitin-linkage type mediated by the APC/C complex. Also mediates deubiquitination of 'Lys-48'-linked polyubiquitin chains in vitro. Phosphorylation at Ser-628 during G1/S phase maximizes the deubiquitinase activity, leading to prevent degradation of cyclin-A (CCNA1 and CCNA2) (PubMed:21596315). Plays an important role in the regulation of DNA replication by stabilizing the licensing factor CDT1 (PubMed:27296872). [UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Stabilization of estrogen receptor α by USP37 contributes to the progression of breast cancer.

Cancer science

Cao J,Wang X,Wang S,Chen Z,Tang J

Mon May 01 00:00:00 UTC 2023

Stabilization of estrogen receptor α by USP37 contributes to the progression of breast cancer.

Cancer science

Cao J,Wang X,Wang S,Chen Z,Tang J

Mon May 01 00:00:00 UTC 2023

Stabilization of estrogen receptor α by USP37 contributes to the progression of breast cancer.

Cancer science

Cao J,Wang X,Wang S,Chen Z,Tang J

Mon May 01 00:00:00 UTC 2023

Stabilization of estrogen receptor α by USP37 contributes to the progression of breast cancer.

Cancer science

Cao J,Wang X,Wang S,Chen Z,Tang J

Mon May 01 00:00:00 UTC 2023

Stabilization of estrogen receptor α by USP37 contributes to the progression of breast cancer.

Cancer science

Cao J,Wang X,Wang S,Chen Z,Tang J

Mon May 01 00:00:00 UTC 2023

Stabilization of estrogen receptor α by USP37 contributes to the progression of breast cancer.

Cancer science

Cao J,Wang X,Wang S,Chen Z,Tang J

Mon May 01 00:00:00 UTC 2023

Stabilization of estrogen receptor α by USP37 contributes to the progression of breast cancer.

Cancer science

Cao J,Wang X,Wang S,Chen Z,Tang J

Mon May 01 00:00:00 UTC 2023

Stabilization of estrogen receptor α by USP37 contributes to the progression of breast cancer.

Cancer science

Cao J,Wang X,Wang S,Chen Z,Tang J

Mon May 01 00:00:00 UTC 2023

Topoisomerase IIA in adult NSCs regulates SVZ neurogenesis by transcriptional activation of Usp37.

Nucleic acids research

Qin S,Yuan Y,Huang X,Tan Z,Hu X,Liu H,Pu Y,Ding YQ,Su Z,He C

Fri Sep 09 00:00:00 UTC 2022

USP37 downregulation elevates the Chemical Sensitivity of Human Breast Cancer Cells to Adriamycin.

International journal of medical sciences

Qin T,Cui XY,Xiu H,Huang C,Sun ZN,Xu XM,Li LH,Yue L

Mon Sep 13 00:00:00 UTC 2021

USP37 downregulation elevates the Chemical Sensitivity of Human Breast Cancer Cells to Adriamycin.

International journal of medical sciences

Qin T,Cui XY,Xiu H,Huang C,Sun ZN,Xu XM,Li LH,Yue L

Mon Sep 13 00:00:00 UTC 2021

PLAGL2 promotes the proliferation and migration of gastric cancer cells via USP37-mediated deubiquitination of Snail1.

Theranostics

Wu L,Zhao N,Zhou Z,Chen J,Han S,Zhang X,Bao H,Yuan W,Shu X

Wed Aug 04 00:00:00 UTC 2021

Specific Deubiquitinating Enzymes Promote Host Restriction Factors Against HIV/SIV Viruses.

Frontiers in immunology

Gao W,Rui Y,Li G,Zhai C,Su J,Liu H,Zheng W,Zheng B,Zhang W,Yang Y,Hua S,Yu X

Wed Jan 05 00:00:00 UTC 2022

USP37 regulates DNA damage response through stabilizing and deubiquitinating BLM.

Nucleic acids research

Wu C,Chang Y,Chen J,Su Y,Li L,Chen Y,Li Y,Wu J,Huang J,Zhao F,Wang W,Yin H,Wang S,Jin M,Lou Z,Zhu WG,Luo K,Zhang J,Yuan J

Mon Nov 08 00:00:00 UTC 2021

USP37 regulates DNA damage response through stabilizing and deubiquitinating BLM.

Nucleic acids research

Wu C,Chang Y,Chen J,Su Y,Li L,Chen Y,Li Y,Wu J,Huang J,Zhao F,Wang W,Yin H,Wang S,Jin M,Lou Z,Zhu WG,Luo K,Zhang J,Yuan J

Mon Nov 08 00:00:00 UTC 2021

USP37 regulates DNA damage response through stabilizing and deubiquitinating BLM.

Nucleic acids research

Wu C,Chang Y,Chen J,Su Y,Li L,Chen Y,Li Y,Wu J,Huang J,Zhao F,Wang W,Yin H,Wang S,Jin M,Lou Z,Zhu WG,Luo K,Zhang J,Yuan J

Mon Nov 08 00:00:00 UTC 2021

USP37 Promotes Lung Cancer Cell Migration by Stabilizing Snail Protein via Deubiquitination.

Frontiers in genetics

Cai J,Li M,Wang X,Li L,Li Q,Hou Z,Jia H,Liu S

Tue Sep 29 00:00:00 UTC 2020

Abnormally elevated USP37 expression in breast cancer stem cells regulates stemness, epithelial-mesenchymal transition and cisplatin sensitivity.

Journal of experimental & clinical cancer research : CR

Qin T,Li B,Feng X,Fan S,Liu L,Liu D,Mao J,Lu Y,Yang J,Yu X,Zhang Q,Zhang J,Song B,Li M,Li L

Tue Nov 27 00:00:00 UTC 2018

Abnormally elevated USP37 expression in breast cancer stem cells regulates stemness, epithelial-mesenchymal transition and cisplatin sensitivity.

Journal of experimental & clinical cancer research : CR

Qin T,Li B,Feng X,Fan S,Liu L,Liu D,Mao J,Lu Y,Yang J,Yu X,Zhang Q,Zhang J,Song B,Li M,Li L

Tue Nov 27 00:00:00 UTC 2018

Abnormally elevated USP37 expression in breast cancer stem cells regulates stemness, epithelial-mesenchymal transition and cisplatin sensitivity.

Journal of experimental & clinical cancer research : CR

Qin T,Li B,Feng X,Fan S,Liu L,Liu D,Mao J,Lu Y,Yang J,Yu X,Zhang Q,Zhang J,Song B,Li M,Li L

Tue Nov 27 00:00:00 UTC 2018

Abnormally elevated USP37 expression in breast cancer stem cells regulates stemness, epithelial-mesenchymal transition and cisplatin sensitivity.

Journal of experimental & clinical cancer research : CR

Qin T,Li B,Feng X,Fan S,Liu L,Liu D,Mao J,Lu Y,Yang J,Yu X,Zhang Q,Zhang J,Song B,Li M,Li L

Tue Nov 27 00:00:00 UTC 2018

Abnormally elevated USP37 expression in breast cancer stem cells regulates stemness, epithelial-mesenchymal transition and cisplatin sensitivity.

Journal of experimental & clinical cancer research : CR

Qin T,Li B,Feng X,Fan S,Liu L,Liu D,Mao J,Lu Y,Yang J,Yu X,Zhang Q,Zhang J,Song B,Li M,Li L

Tue Nov 27 00:00:00 UTC 2018

CYLD regulates spindle orientation by stabilizing astral microtubules and promoting dishevelled-NuMA-dynein/dynactin complex formation.

Proceedings of the National Academy of Sciences of the United States of America

Yang Y,Liu M,Li D,Ran J,Gao J,Suo S,Sun SC,Zhou J

Tue Feb 11 00:00:00 UTC 2014

CYLD regulates spindle orientation by stabilizing astral microtubules and promoting dishevelled-NuMA-dynein/dynactin complex formation.

Proceedings of the National Academy of Sciences of the United States of America

Yang Y,Liu M,Li D,Ran J,Gao J,Suo S,Sun SC,Zhou J

Tue Feb 11 00:00:00 UTC 2014

The HBx oncoprotein of hepatitis B virus deregulates the cell cycle by promoting the intracellular accumulation and re-compartmentalization of the cellular deubiquitinase USP37.

PloS one

Saxena N,Kumar V

Thu Dec 24 00:00:00 UTC 2015

The HBx oncoprotein of hepatitis B virus deregulates the cell cycle by promoting the intracellular accumulation and re-compartmentalization of the cellular deubiquitinase USP37.

PloS one

Saxena N,Kumar V

Thu Dec 24 00:00:00 UTC 2015

The HBx oncoprotein of hepatitis B virus deregulates the cell cycle by promoting the intracellular accumulation and re-compartmentalization of the cellular deubiquitinase USP37.

PloS one

Saxena N,Kumar V

Thu Dec 24 00:00:00 UTC 2015

The HBx oncoprotein of hepatitis B virus deregulates the cell cycle by promoting the intracellular accumulation and re-compartmentalization of the cellular deubiquitinase USP37.

PloS one

Saxena N,Kumar V

Thu Dec 24 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: Deubiquitinating enzyme 37; tmp_locus_50; Ubiquitin carboxyl-terminal hydrolase 37; ubiquitin specific peptidase 37; ubiquitin specific peptidase 37-like; ubiquitin specific protease 37; Ubiquitin thioesterase 37; ubiquitin thiolesterase 37; Ubiquitin-specific-processing protease 37; usp37

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Gene Aliases: 4932415L06Rik; C330008N13Rik; KIAA1594; USP37

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UniProt ID: (Human) Q86T82, (Mouse) Q8C0R0

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Entrez Gene ID: (Human) 57695, (Mouse) 319651, (Rat) 100361658

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cysteine-type endopeptidase activity thiol-dependent ubiquitin-specific protease activity protein binding protein kinase binding peptidase activity cysteine-type peptidase activity hydrolase activity thiol-dependent ubiquitinyl hydrolase activity

G1/S transition of mitotic cell cycle proteolysis ubiquitin-dependent protein catabolic process cell cycle mitotic nuclear division protein deubiquitination protein K11-linked deubiquitination proteasome-mediated ubiquitin-dependent protein catabolic process cell division regulation of proteasomal protein catabolic process protein K48-linked deubiquitination

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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