Proteintech

USP39 Polyclonal Antibody

USP39 Antibody in Immunocytochemistry (ICC/IF)

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USP39 Antibody (23865-1-AP) in ICC/IF

Immunofluorescent analysis of HUVEC cells using 23865-1-AP (USP39 antibody) at dilution of 1:25 and Rhodamine-Goat anti-Rabbit IGG.

USP39 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

USP39 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

23865-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 10 publications 10 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200

Immunocytochemistry (ICC/IF)

1:10-1:100

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

View 2 publications 2 publications

RNA Immunoprecipitation (RIP)

View 3 publications 3 publications

Miscellaneous PubMed (MISC)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

USP39 Fusion Protein Ag20894 (1-357 aa encoded by BC067273)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MSGRSKRES RGSTRGKRES ESRGSSGRVK RERDREREPE AASSRGSPVR VKREFEPASA REAPASVVPF VRVKREREVD EDSEPEREVR AKNGRVDSED RRSRHCPYLD TINRSVLDFD FEKLCSISLS HINAYACLVC GKYFQGRGLK SHAYIHSVQF SHHVFLNLHT LKFYCLPDNY EIIDSSLEDI TYVLKPTFTK QQIANLDKQA KLSRAYDGTT YLPGIVGLNN IKANDYANAV LQALSNVPPL RNYFLEEDNY KNIKRPPGDI MFLLVQRFGE LMRKLWNPRN FKAHVSPHEM LQAVVLCSKK TFQITKQGDG VDFLSWFLNA LHSALGGTKK KKKTIVTDVF QGSMRIFT (1-357 aa encoded by BC067273)

Target Information

USP39 may play a role in mRNA splicing. It is unsure if the protein really exhibits hydrolase activity. It could be a competitor of ubiquitin C-terminal hydrolases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Lysine 2-hydroxyisobutyrylation of NAT10 promotes cancer metastasis in an ac4C-dependent manner.

Cell research

Liao L,He Y,Li SJ,Yu XM,Liu ZC,Liang YY,Yang H,Yang J,Zhang GG,Deng CM,Wei X,Zhu YD,Xu TY,Zheng CC,Cheng C,Li A,Li ZG,Liu JB,Li B

Mon May 01 00:00:00 UTC 2023

Lysine 2-hydroxyisobutyrylation of NAT10 promotes cancer metastasis in an ac4C-dependent manner.

Cell research

Liao L,He Y,Li SJ,Yu XM,Liu ZC,Liang YY,Yang H,Yang J,Zhang GG,Deng CM,Wei X,Zhu YD,Xu TY,Zheng CC,Cheng C,Li A,Li ZG,Liu JB,Li B

Mon May 01 00:00:00 UTC 2023

DNAAF5 promotes hepatocellular carcinoma malignant progression by recruiting USP39 to improve PFKL protein stability.

Frontiers in oncology

Liu Y,Wu Q,Sun T,Huang J,Han G,Han H

Tue Oct 25 00:00:00 UTC 2022

USP39 facilitates breast cancer cell proliferation through stabilization of FOXM1.

American journal of cancer research

Zhang Z,Liu W,Bao X,Sun T,Wang J,Li M,Liu C

Tue Sep 20 00:00:00 UTC 2022

USP39 facilitates breast cancer cell proliferation through stabilization of FOXM1.

American journal of cancer research

Zhang Z,Liu W,Bao X,Sun T,Wang J,Li M,Liu C

Tue Sep 20 00:00:00 UTC 2022

The Deubiquitinase USP39 Promotes Esophageal Squamous Cell Carcinoma Malignancy as a Splicing Factor.

Genes

Zhu X,Ma J,Lu M,Liu Z,Sun Y,Chen H

Tue May 03 00:00:00 UTC 2022

The LINC00623/NAT10 signaling axis promotes pancreatic cancer progression by remodeling ac4C modification of mRNA.

Journal of hematology & oncology

Feng Z,Li K,Qin K,Liang J,Shi M,Ma Y,Zhao S,Liang H,Han D,Shen B,Peng C,Chen H,Jiang L

Wed Aug 17 00:00:00 UTC 2022

Ubiquitin-specific peptidase 39 promotes human glioma cells migration and invasion by facilitating ADAM9 mRNA maturation.

Molecular oncology

Xiao Y,Ma W,Hu W,Di Q,Zhao X,Ma X,Chen X,Sun P,Wu H,Wu Z,Chen W

Sat Jan 01 00:00:00 UTC 2022

Ubiquitin-specific peptidase 39 promotes human glioma cells migration and invasion by facilitating ADAM9 mRNA maturation.

Molecular oncology

Xiao Y,Ma W,Hu W,Di Q,Zhao X,Ma X,Chen X,Sun P,Wu H,Wu Z,Chen W

Sat Jan 01 00:00:00 UTC 2022

Ubiquitin-specific peptidase 39 promotes human glioma cells migration and invasion by facilitating ADAM9 mRNA maturation.

Molecular oncology

Xiao Y,Ma W,Hu W,Di Q,Zhao X,Ma X,Chen X,Sun P,Wu H,Wu Z,Chen W

Sat Jan 01 00:00:00 UTC 2022

Ubiquitin-specific peptidase 39 promotes human glioma cells migration and invasion by facilitating ADAM9 mRNA maturation.

Molecular oncology

Xiao Y,Ma W,Hu W,Di Q,Zhao X,Ma X,Chen X,Sun P,Wu H,Wu Z,Chen W

Sat Jan 01 00:00:00 UTC 2022

MiR-1281, a p53-responsive microRNA, impairs the survival of human osteosarcoma cells upon ER stress via targeting USP39.

American journal of cancer research

Jiang J,Ma B,Li X,Jin W,Han C,Wang L,Wang H

Thu Oct 01 00:00:00 UTC 2020

MiR-1281, a p53-responsive microRNA, impairs the survival of human osteosarcoma cells upon ER stress via targeting USP39.

American journal of cancer research

Jiang J,Ma B,Li X,Jin W,Han C,Wang L,Wang H

Thu Oct 01 00:00:00 UTC 2020

Knockdown of ubiquitin-specific peptidase 39 inhibited the growth of osteosarcoma cells and induced apoptosis in vitro.

Biological research

Gan Z,Han K,Lin S,Hu H,Shen Z,Min D

Wed Apr 12 00:00:00 UTC 2017

Knockdown of ubiquitin-specific peptidase 39 inhibited the growth of osteosarcoma cells and induced apoptosis in vitro.

Biological research

Gan Z,Han K,Lin S,Hu H,Shen Z,Min D

Wed Apr 12 00:00:00 UTC 2017

Identification of a 35S U4/U6.U5 tri-small nuclear ribonucleoprotein (tri-snRNP) complex intermediate in spliceosome assembly.

The Journal of biological chemistry

Chen Z,Gui B,Zhang Y,Xie G,Li W,Liu S,Xu B,Wu C,He L,Yang J,Yi X,Yang X,Sun L,Liang J,Shang Y

Fri Nov 03 00:00:00 UTC 2017

Identification of a 35S U4/U6.U5 tri-small nuclear ribonucleoprotein (tri-snRNP) complex intermediate in spliceosome assembly.

The Journal of biological chemistry

Chen Z,Gui B,Zhang Y,Xie G,Li W,Liu S,Xu B,Wu C,He L,Yang J,Yi X,Yang X,Sun L,Liang J,Shang Y

Fri Nov 03 00:00:00 UTC 2017

Identification of a 35S U4/U6.U5 tri-small nuclear ribonucleoprotein (tri-snRNP) complex intermediate in spliceosome assembly.

The Journal of biological chemistry

Chen Z,Gui B,Zhang Y,Xie G,Li W,Liu S,Xu B,Wu C,He L,Yang J,Yi X,Yang X,Sun L,Liang J,Shang Y

Fri Nov 03 00:00:00 UTC 2017

Identification of a 35S U4/U6.U5 tri-small nuclear ribonucleoprotein (tri-snRNP) complex intermediate in spliceosome assembly.

The Journal of biological chemistry

Chen Z,Gui B,Zhang Y,Xie G,Li W,Liu S,Xu B,Wu C,He L,Yang J,Yi X,Yang X,Sun L,Liang J,Shang Y

Fri Nov 03 00:00:00 UTC 2017

Ubiquitin-specific protease 39 is overexpressed in human lung cancer and promotes tumor cell proliferation in vitro.

Molecular and cellular biochemistry

Lin Z,Xiong L,Lin Q

Tue Nov 01 00:00:00 UTC 2016

Ubiquitin-specific protease 39 is overexpressed in human lung cancer and promotes tumor cell proliferation in vitro.

Molecular and cellular biochemistry

Lin Z,Xiong L,Lin Q

Tue Nov 01 00:00:00 UTC 2016

Lentivirus-mediated inhibition of USP39 suppresses the growth of gastric cancer cells via PARP activation.

Molecular medicine reports

Wang X,Yu Q,Huang L,Yu P

Fri Jul 01 00:00:00 UTC 2016

Lentivirus-mediated inhibition of USP39 suppresses the growth of gastric cancer cells via PARP activation.

Molecular medicine reports

Wang X,Yu Q,Huang L,Yu P

Fri Jul 01 00:00:00 UTC 2016

Overexpression of USP39 predicts poor prognosis and promotes tumorigenesis of prostate cancer via promoting EGFR mRNA maturation and transcription elongation.

Oncotarget

Huang Y,Pan XW,Li L,Chen L,Liu X,Lu JL,Zhu XM,Huang H,Yang QW,Ye JQ,Gan SS,Wang LH,Hong Y,Xu DF,Cui XG

Tue Apr 19 00:00:00 UTC 2016

Overexpression of USP39 predicts poor prognosis and promotes tumorigenesis of prostate cancer via promoting EGFR mRNA maturation and transcription elongation.

Oncotarget

Huang Y,Pan XW,Li L,Chen L,Liu X,Lu JL,Zhu XM,Huang H,Yang QW,Ye JQ,Gan SS,Wang LH,Hong Y,Xu DF,Cui XG

Tue Apr 19 00:00:00 UTC 2016

Overexpression of USP39 predicts poor prognosis and promotes tumorigenesis of prostate cancer via promoting EGFR mRNA maturation and transcription elongation.

Oncotarget

Huang Y,Pan XW,Li L,Chen L,Liu X,Lu JL,Zhu XM,Huang H,Yang QW,Ye JQ,Gan SS,Wang LH,Hong Y,Xu DF,Cui XG

Tue Apr 19 00:00:00 UTC 2016

Overexpression of USP39 predicts poor prognosis and promotes tumorigenesis of prostate cancer via promoting EGFR mRNA maturation and transcription elongation.

Oncotarget

Huang Y,Pan XW,Li L,Chen L,Liu X,Lu JL,Zhu XM,Huang H,Yang QW,Ye JQ,Gan SS,Wang LH,Hong Y,Xu DF,Cui XG

Tue Apr 19 00:00:00 UTC 2016

Knockdown of USP39 by lentivirus-mediated RNA interference suppresses the growth of oral squamous cell carcinoma.

Cancer biomarkers : section A of Disease markers

Li KY,Zhang J,Jiang LC,Zhang B,Xia CP,Xu K,Chen HY,Yang QZ,Liu SW,Zhu H

Fri Nov 04 00:00:00 UTC 2016

Reduced USP39 expression inhibits malignant proliferation of medullary thyroid carcinoma in vitro.

World journal of surgical oncology

An Y,Yang S,Guo K,Ma B,Wang Y

Tue Aug 25 00:00:00 UTC 2015

Reduced USP39 expression inhibits malignant proliferation of medullary thyroid carcinoma in vitro.

World journal of surgical oncology

An Y,Yang S,Guo K,Ma B,Wang Y

Tue Aug 25 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: inactive ubiquitin-specific peptidase 39; SAD1 homolog; small nuclear ribonucleoprotein 65kDa (U4/U6.U5); SnRNP assembly defective 1 homolog; U4/U6.U5 tri-snRNP-associated 65 kDa protein; Ubiquitin carboxyl-terminal hydrolase 39; ubiquitin specific protease 39

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Gene Aliases: 65K; CGI-21; HSPC332; PRO2855; SAD1; SNRNP65; USP39

View more View less

UniProt ID: (Human) Q53GS9

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Entrez Gene ID: (Human) 10713

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Function(s)

zinc ion binding thiol-dependent ubiquitinyl hydrolase activity

Process(es)

spliceosomal complex assembly mRNA splicing, via spliceosome mRNA processing cell cycle RNA splicing protein deubiquitination cell division

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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USP39 Polyclonal Antibody

USP39 Antibody (23865-1-AP) in ICC/IF

Product Details

23865-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

RNA Immunoprecipitation (RIP)

Miscellaneous PubMed (MISC)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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