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USP47 Antibody (IHC-00235) in IHC (P)
Detection of human USP47 by immunohistochemistry. Sample: FFPE section of human prostate adenocarcinoma. Antibody: Affinity purified rabbit anti-USP47 (Product # IHC-00235) used at a dilution of 1:100. Detection: Red-fluorescent Alexa Fluor® 555 goat anti-rabbit IgG (Invitrogen) used at a dilution of 1:500.
Product Details
IHC-00235
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 1237 and the C-terminus (residue 1287) of Human ubiquitin specific peptidase 47.
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.0 to 8.0, with 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Wet ice
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Chicken, Turkey, Bovine, Dog, Rabbit, Pig, Panda, Orangutan, Monkey, Gorilla, Chimpanzee and Naked mole rat
Target Information
Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulate CDC25A expression at a transcriptional level. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Deubiquitinating enzyme 47; Trf (TATA binding protein-related factor)-proximal homolog; Ubiquitin carboxyl-terminal hydrolase 47; ubiquitin specific protease 47; Ubiquitin thioesterase 47; ubiquitin thiolesterase 47; Ubiquitin-specific-processing protease 47
Gene Aliases: 4930502N04Rik; A630020C16Rik; TRFP; USP47
UniProt ID: (Human) Q8TEP6, (Mouse) Q8BY87
Entrez Gene ID: (Human) 55031, (Mouse) 74996
base-excision repair
ubiquitin-dependent protein catabolic process
cellular response to DNA damage stimulus
negative regulation of G2/M transition of mitotic cell cycle
positive regulation of cell growth
cellular response to UV
monoubiquitinated protein deubiquitination
response to drug
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of transcription, DNA-templated
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
DNA repair
proteolysis
protein deubiquitination
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of proteasomal protein catabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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