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Abnova
USP9X Monoclonal Antibody (3E12)
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Product Details
H00008239-M06
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
3E12
Immunogen
USP9X (NP_068706, 1 a.a. approximately 90 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
0.5-1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MTATTRGSPV GGNDNQGQAP DGQSQPPLQQ NQTSSPDSSN ENSPATPPDE QGQGDAPPQL EDEEPAFPHT DLAKLDDMIN RPRWVVPVLP
Target Information
USP9X is an ubiquitin-specific protease involved in the removal and recycling of ubiquitin from proteins degraded in proteasomes. As a deubiquitinating enzyme, USP9x has a critical function in tight junction biogenesis by controlling the levels of the exchange factor for Arf6 (EFA6), a protein shown to facilitate tight junction formation during a narrow temporal window preceding the establishment of cell polarity. USP9X is also located on the X-chromosome but escapes X-inactivation, and defects in USP9X may cause gonadal degeneration in Turner syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Deubiquitinating enzyme FAF-X; Drosophila fat facets related, X-linked; Fat facets in mammals; fat facets protein related, X-linked; Fat facets protein-related, X-linked; hFAM; Ubiquitin carboxyl-terminal hydrolase 9X; ubiquitin specific protease 9, X chromosome (fat facets-like Drosophila); Ubiquitin thioesterase FAF-X; ubiquitin thiolesterase FAF-X; ubiquitin-specific processing protease FAF-X; Ubiquitin-specific protease 9, X chromosome; Ubiquitin-specific-processing protease FAF-X
Gene Aliases: DFFRX; FAF; FAM; MRX99; MRXS99F; USP9; USP9X
UniProt ID: (Human) Q93008
Entrez Gene ID: (Human) 8239
negative regulation of transcription from RNA polymerase II promoter
neuron migration
ubiquitin-dependent protein catabolic process
chromosome segregation
mitotic nuclear division
transforming growth factor beta receptor signaling pathway
female gamete generation
protein deubiquitination
BMP signaling pathway
cellular protein metabolic process
axon extension
cell division
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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