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Invitrogen
UTRN Polyclonal Antibody
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FIGURE: 1 / 2
UTRN Antibody (PA5-143876) in ICC/IF
Immunocytochemistry analysis of UTRN in Caco-2 cells. Enzyme antigen retrieval was performed using IHC enzyme antigen retrieval reagent for 15 mins. The cells were blocked with 10% goat serum. Samples were then incubated in UTRN Polyclonal antibody (Product # PA5-143876) using a dilution of 5 μg/mL. DyLight®488 Conjugated Goat Anti-Rabbit IgG was used as secondary antibody at 1:100 dilution and incubated for 30 minutes at 37°C. The section was counterstained with DAPI. Visualize using a fluorescence microscope and filter sets appropriate f... View More
Product Details
PA5-143876
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E.coli-derived human Utrophin/UTRN recombinant protein (Position: L1211-K2294).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 4mg trehalose
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_3075090
Product Specific Information
Adding 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
Positive Control - WB: human Hela whole cell, human Sw620 whole cell, human Caco-2 whole cell, human THP-1 whole cell, mouse lung tissue. ICC/IF: CACO-2 cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Target Information
The UTRN gene encodes the utrophin protein, which is closely related to dystrophin in structure and function, playing a crucial role in maintaining the integrity of muscle fiber membranes. Located on chromosome 6, utrophin is expressed widely in fetal tissues but is replaced by dystrophin in mature muscle fibers; however, it remains present in adult tissues such as the neuromuscular junction and blood vessels. Utrophin's primary role is to stabilize the cytoskeleton and membrane linkages, forming part of the protein complex responsible for structural support in muscle cells. This protein has garnered significant attention in the context of muscular dystrophies, particularly Duchenne Muscular Dystrophy (DMD), where utrophin upregulation is considered a potential therapeutic strategy to compensate for the lack of functional dystrophin. It helps to ameliorate muscle pathology by mimicking the stabilizing effects of dystrophin, thus preserving muscle function and reducing damage. Research on enhancing utrophin expression is ongoing, aiming to provide an effective treatment modality for DMD and other dystrophin-associated disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DRP-1; Dystrophin-related protein 1; G-utrophin; Utrophin; utrophin short isoform, Up109
Gene Aliases: AA589569; DMDL; DRP; DRP1; UTRN
UniProt ID: (Human) P46939
Entrez Gene ID: (Human) 7402, (Mouse) 22288
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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