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Invitrogen
Ubinuclein 1 Polyclonal Antibody
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FIGURE: 1 / 7
Ubinuclein 1 Antibody (PA5-103360) in ICC/IF
Immunocytochemistry analysis of Ubinuclein 1 in Hela cells. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25°C. Samples were incubated with Ubinuclein 1 polyclonal antibody (Product # PA5-103360) and mouse anti-beta tubulin antibody for 1 hour at 37°C. An AlexaFluor594 conjugated goat anti-rabbit IgG (Red) and an AlexaFluor488 conjugated ... View More
Product Details
PA5-103360
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human UBN1(Accession Q9NPG3), corresponding to amino acid residues Q303-L353.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2852704
Product Specific Information
Antibody detects endogenous levels of total Ubinuclein.
Target Information
Cellular senescence is a hallmark of tumor suppression and tissue aging. Senescent cells contain domains of heterochromatin, called senescence-associated heterochromatin foci (SAHF), that repress proliferation-promoting genes. The protein encoded by this gene binds to proliferation-promoting genes and is required for SAHF formation, enhancing methylation of histone H3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HIRA-binding protein; Protein VT4; Ubinuclein-1; Ubiquitously expressed nuclear protein
Gene Aliases: 1110029L11Rik; 2610108L02Rik; AA673476; AW124741; UBN1; VT; VT4
UniProt ID: (Human) Q9NPG3, (Mouse) Q4G0F8
Entrez Gene ID: (Human) 29855, (Mouse) 170644
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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