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Ubinuclein 2 Antibody (PA5-71822) in WB
Western blot analysis of Ubinuclein 2 in various lysates. Samples were incubated with Ubinuclein 2 polyclonal antibody (Product # PA5-71822) using a dilution of 1:1,000 followed by Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at a dilution of 1:10,000. Lysates/proteins: 20 µg per lane. Lane 1: Ramos whole cell lysate; Lane 2: U-2OS whole cell lysate. Predicted band size: 146 kDa. Blocking/Dilution buffer: 5% NFDM/TBST.
Product Details
PA5-71822
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 171-200 amino acids from the N-terminal region of human UBN2
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2717676
Target Information
Ubinuclein 1 (UBN1) is a ubiquitously expressed evolutionarily conserved protein which binds to proliferation-promoting genes that are repressed by formation of senescence-associated heterochromatin foci (SAHF). Ubinuclein 1 associates with various transcription factors and with histone methyltransferase activity, is indispensable for SAHF formation and appears to be a regulator of senescence. Although in most cells ubinuclein is localized to the nucleus, in cells forming tight junctions it is recruited to the cell adhesion complexes, dependently on the cell density.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ubinuclein 1; Ubinuclein-2; UBN1; VT; VT4
Gene Aliases: 2900060J04Rik; 6030408G03Rik; BC060116; D130059P03Rik; KIAA2030; mKIAA2030; UBN2
UniProt ID: (Human) Q6ZU65, (Mouse) Q80WC1
Entrez Gene ID: (Human) 254048, (Mouse) 320538
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