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Invitrogen
Ubiquilin 2 Monoclonal Antibody (3B8A10)
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FIGURE: 1 / 8
Ubiquilin 2 Antibody (35-4400) in ICC/IF
Immunofluorescence analysis of Dsk2 Monoclonal Antibody (3B8A10) was performed using 70% confluent log phase SH-SY5Y cells treated with 1 uM Nocodazole for 12 h. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 1% BSA for 1 hour at room temperature. The cells were labeled with Dsk2 (3B8A10) Mouse Monoclonal Antibody at 2 µg/... View More
Product Details
35-4400
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human,
Mouse
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
3B8A10
Immunogen
Recombinant protein corresponding to the C-terminal region of the human ubiquilin protein
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
0.1% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2533204
Target Information
This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases; and thus, are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to bind the ATPase domain of the Hsp70-like Stch protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Chap1; DSK2 homolog; Nedd4 binding protein 4; PLIC-2; Protein linking IAP with cytoskeleton 2; Ubiquilin-2; Ubiquitin-like product Chap1/Dsk2
Gene Aliases: ALS15; CHAP1; DSK2; HRIHFB2157; N4BP4; PLIC2; UBQLN2
UniProt ID: (Human) Q9UHD9
Entrez Gene ID: (Human) 29978
autophagy
regulation of macroautophagy
ER-associated ubiquitin-dependent protein catabolic process
negative regulation of clathrin-mediated endocytosis
positive regulation of ER-associated ubiquitin-dependent protein catabolic process
negative regulation of G-protein coupled receptor internalization
regulation of autophagosome assembly
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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