Product References
Neuronal membrane proteasomes regulate neuronal circuit activity in vivo and are required for learning-induced behavioral plasticity.
Proceedings of the National Academy of Sciences of the United States of America
He HY,Ahsan A,Bera R,McLain N,Faulkner R,Ramachandran KV,Margolis SS,Cline HT
13-1600 was used in Western Blotting to investigate the in vivo function of the 20S neuronal membrane proteasome (NMP) in the brain of Xenopus laevis tadpoles.
Tue Jan 17 00:00:00 UTC 2023
Ubiquitination of the protocadherin-γA3 variable cytoplasmic domain modulates cell-cell interaction.
Frontiers in cell and developmental biology
Ptashnik A,LaMassa N,Mambetalieva A,Schnall E,Bucaro M,Phillips GR
13-1600 was used in Western Blot to investigate if Pcdh-γA ubiquitination can influence surface expression which may modulate adhesive activity during neural development.
Thu Oct 05 00:00:00 UTC 2023
The pro-tumorigenic cytokine IL-32 has a high turnover in multiple myeloma cells due to proteolysis regulated by oxygen-sensing cysteine dioxygenase and deubiquitinating enzymes.
Frontiers in oncology
Kastnes M,Aass KR,Bouma SA,Årseth C,Zahoor M,Yurchenko M,Standal T
13-1600 was used in Western Blotting to demonstrate that high-speed translation and ubiquitin-dependent proteasomal degradation lead to a rapid IL-32 protein turnover.
Thu Jun 15 00:00:00 UTC 2023
Interfering with mitochondrial dynamics sensitizes glioblastoma multiforme to temozolomide chemotherapy.
Journal of cellular and molecular medicine
Wang N,Huang R,Yang K,He Y,Gao Y,Dong D
13-1600 was used in Western Blot to explore the mechanism of GBM chemo-resistance from the perspective of energy metabolism.
Tue Feb 01 00:00:00 UTC 2022
Genipin Attenuates Diabetic Cognitive Impairment by Reducing Lipid Accumulation and Promoting Mitochondrial Fusion via FABP4/Mfn1 Signaling in Microglia.
Antioxidants (Basel, Switzerland)
Liu W,Li K,Zheng M,He L,Chen T
13-1600 was used in ELISA, Immunohistochemistry, Immunoprecipitation, Western Blot to show that GEN attenuated diabetic cognitive impairment by inhibiting inflammation, lipid accumulation and promoting mitochondrial fusion via FABP4/Mfn1 signaling.
Thu Dec 29 00:00:00 UTC 2022
Epithelial SMYD5 Exaggerates IBD by Down-regulating Mitochondrial Functions via Post-Translational Control of PGC-1α Stability.
Cellular and molecular gastroenterology and hepatology
Hou Y,Sun X,Gheinani PT,Guan X,Sharma S,Zhou Y,Jin C,Yang Z,Naren AP,Yin J,Denning TL,Gewirtz AT,Liu Y,Xie Z,Li C
13-1600 was used in Western Blotting to investigate the role and underlying mechanism of epithelial SMYD5 in IBD pathogenesis and progression.
Mon Jul 25 00:00:00 UTC 2022
Divergent self-association properties of paralogous proteins TRIM2 and TRIM3 regulate their E3 ligase activity.
Nature communications
Esposito D,Dudley-Fraser J,Garza-Garcia A,Rittinger K
13-1600 was used in Western Blotting to present a detailed structure-function analysis of TRIM2 and TRIM3, which despite high sequence identity, exhibit markedly different self-association and activity profiles.
Thu Dec 08 00:00:00 UTC 2022
Evidence that the transcriptional repressor ICER is regulated via the N-end rule for ubiquitination.
Experimental cell research
Cirinelli A,Wheelan J,Grieg C,Molina CA
13-1600 was used in Western Blotting to find that NHAICER inhibits transcription two times more efficiently than ICERCHA, and causes apoptosis 5 times more efficiently than ICERCHA.
Sun May 01 00:00:00 UTC 2022
Activation of the ubiquitin-proteasome system contributes to oculopharyngeal muscular dystrophy through muscle atrophy.
PLoS genetics
Ribot C,Soler C,Chartier A,Al Hayek S,Naït-Saïdi R,Barbezier N,Coux O,Simonelig M
13-1600 was used in Western Blot to study the functional importance of ubiquitin-proteasome system deregulation in oculopharyngeal muscular dystrophy (OPMD) using a Drosophila model of OPMD.
Sat Jan 01 00:00:00 UTC 2022
GMPPA defects cause a neuromuscular disorder with α-dystroglycan hyperglycosylation.
The Journal of clinical investigation
Franzka P,Henze H,Jung MJ,Schüler SC,Mittag S,Biskup K,Liebmann L,Kentache T,Morales J,Martínez B,Katona I,Herrmann T,Huebner AK,Hennings JC,Groth S,Gresing L,Horstkorte R,Marquardt T,Weis J,Kaether C,Mutchinick OM,Ori A,Huber O,Blanchard V,von Maltzahn J,Hübner CA
13-1600 was used in Western Blot to investigate whether GDP-mannose-pyrophosphorylase-A plays a role in the glycosylation of α-dystroglycan, thus explaining it's role in neurodegeneration when mutated.
Mon May 03 00:00:00 UTC 2021
Suppressing TRAP1 sensitizes glioblastoma multiforme cells to temozolomide.
Experimental and therapeutic medicine
Wang N,Zhu P,Huang R,Sun L,Dong D,Gao Y
13-1600 was used in Western Blot to show that TRAP1 is therefore considered to be a promising target for GBM therapy.
Mon Nov 01 00:00:00 UTC 2021
The Pah-R261Q mouse reveals oxidative stress associated with amyloid-like hepatic aggregation of mutant phenylalanine hydroxylase.
Nature communications
Aubi O,Prestegård KS,Jung-Kc K,Shi TS,Ying M,Grindheim AK,Scherer T,Ulvik A,McCann A,Spriet E,Thöny B,Martinez A
Published figure using Ubiquitin monoclonal antibody (Product # 13-1600) in Western Blot
Tue Apr 06 00:00:00 UTC 2021
The ubiquitin isopeptidase USP10 deubiquitinates LC3B to increase LC3B levels and autophagic activity.
The Journal of biological chemistry
Jia R,Bonifacino JS
13-1600 was used in Western Blot to identify mechanisms capable of counteracting the targeting of LC3B for proteasomal degradation by the ubiquitin-activating enzyme UBA6 and ubiquitin-conjugating enzyme/ubiquitin ligase BIRC6, which reduces autophagic activity under stress.
Fri Aug 27 00:00:00 UTC 2021
The ubiquitin isopeptidase USP10 deubiquitinates LC3B to increase LC3B levels and autophagic activity.
The Journal of biological chemistry
Jia R,Bonifacino JS
13-1600 was used in Western Blot to identify mechanisms capable of counteracting the targeting of LC3B for proteasomal degradation by the ubiquitin-activating enzyme UBA6 and ubiquitin-conjugating enzyme/ubiquitin ligase BIRC6, which reduces autophagic activity under stress.
Fri Aug 27 00:00:00 UTC 2021
SPTBN1 inhibits inflammatory responses and hepatocarcinogenesis via the stabilization of SOCS1 and downregulation of p65 in hepatocellular carcinoma.
Theranostics
Lin L,Chen S,Wang H,Gao B,Kallakury B,Bhuvaneshwar K,Cahn K,Gusev Y,Wang X,Wu Y,Marshall JL,Zhi X,He AR
13-1600 was used in Western Blot to provide evidence that loss of SPTBN1 in HCC cells increases p65 protein stability via the inhibition of SOCS1 and enhances NF-κB activation, stimulating the release of inflammatory cytokines, which are critical molecular mechanisms for the loss of SPTBN1-induced liver cancer formation.
Thu Jul 29 00:00:00 UTC 2021
SPTBN1 inhibits inflammatory responses and hepatocarcinogenesis via the stabilization of SOCS1 and downregulation of p65 in hepatocellular carcinoma.
Theranostics
Lin L,Chen S,Wang H,Gao B,Kallakury B,Bhuvaneshwar K,Cahn K,Gusev Y,Wang X,Wu Y,Marshall JL,Zhi X,He AR
13-1600 was used in Western Blot to provide evidence that loss of SPTBN1 in HCC cells increases p65 protein stability via the inhibition of SOCS1 and enhances NF-κB activation, stimulating the release of inflammatory cytokines, which are critical molecular mechanisms for the loss of SPTBN1-induced liver cancer formation.
Thu Jul 29 00:00:00 UTC 2021
An Arsenite Relay between PSMD14 and AIRAP Enables Revival of Proteasomal DUB Activity.
Biomolecules
Sukenik S,Braunstein I,Stanhill A
13-1600 was used in Western Blotting to show that arsenite inhibits Psmd14/Rpn11 metalloprotease deubiquitination activity by substituting zinc binding to the MPN/JAMM domain.
Mon Sep 06 00:00:00 UTC 2021
IL-1β suppression of VE-cadherin transcription underlies sepsis-induced inflammatory lung injury.
The Journal of clinical investigation
Xiong S,Hong Z,Huang LS,Tsukasaki Y,Nepal S,Di A,Zhong M,Wu W,Ye Z,Gao X,Rao GN,Mehta D,Rehman J,Malik AB
13-1600 was used in Western Blot to show that bacterial endotoxin lipopolysaccharide and cecal ligation and puncture-induced polymicrobial sepsis decreased the expression of transcription factor cAMP response element binding in lung endothelial cells.
Wed Jul 01 00:00:00 UTC 2020
Genetic Selection Based on a Ste6*C-HA-Ura3 Substrate Identifies New Cytosolic Quality Control Alleles in Saccharomyces cerevisiae.
G3 (Bethesda, Md.)
Chan SN,Prasad R,Matsudaira P
13-1600 was used in Western Blotting to study protein quality control in the cytosol (CytoQC) mechanisms in Saccharomyces cerevisiae.
Mon Jun 01 00:00:00 UTC 2020
Genetic Selection Based on a Ste6*C-HA-Ura3 Substrate Identifies New Cytosolic Quality Control Alleles in Saccharomyces cerevisiae.
G3 (Bethesda, Md.)
Chan SN,Prasad R,Matsudaira P
13-1600 was used in Western Blotting to study protein quality control in the cytosol (CytoQC) mechanisms in Saccharomyces cerevisiae.
Mon Jun 01 00:00:00 UTC 2020
The degradation-promoting roles of deubiquitinases Ubp6 and Ubp3 in cytosolic and ER protein quality control.
PloS one
Wu H,Ng DTW,Cheong I,Matsudaira P
13-1600 was used in Western Blotting to reveal that Ubp6 maintains the level of free ubiquitin to promote the elimination of misfolded cytosolic proteins, while Ubp3 supports the degradation of misfolded cytosolic and ER luminal proteins by different mechanisms.
Wed Jul 29 00:00:00 UTC 2020
The degradation-promoting roles of deubiquitinases Ubp6 and Ubp3 in cytosolic and ER protein quality control.
PloS one
Wu H,Ng DTW,Cheong I,Matsudaira P
13-1600 was used in Western Blotting to reveal that Ubp6 maintains the level of free ubiquitin to promote the elimination of misfolded cytosolic proteins, while Ubp3 supports the degradation of misfolded cytosolic and ER luminal proteins by different mechanisms.
Wed Jul 29 00:00:00 UTC 2020
APOPT1/COA8 assists COX assembly and is oppositely regulated by UPS and ROS.
EMBO molecular medicine
Signes A,Cerutti R,Dickson AS,Benincá C,Hinchy EC,Ghezzi D,Carrozzo R,Bertini E,Murphy MP,Nathan JA,Viscomi C,Fernandez-Vizarra E,Zeviani M
13-1600 was used in Western Blotting to investigate the biochemical link between APOPT1 function and cytochome c oxidase.
Tue Jan 01 00:00:00 UTC 2019
Negative regulation of autophagy by UBA6-BIRC6-mediated ubiquitination of LC3.
eLife
Jia R,Bonifacino JS
Published figure using Ubiquitin monoclonal antibody (Product # 13-1600) in Western Blot
Wed Nov 06 00:00:00 UTC 2019
Replication of multiple system atrophy prions in primary astrocyte cultures from transgenic mice expressing human α-synuclein.
Acta neuropathologica communications
Krejciova Z,Carlson GA,Giles K,Prusiner SB
13-1600 was used in Immunohistochemistry to study the role of astrocytes in multiple system atrophy.
Mon May 20 00:00:00 UTC 2019
A Mycobacterium tuberculosis surface protein recruits ubiquitin to trigger host xenophagy.
Nature communications
Chai Q,Wang X,Qiang L,Zhang Y,Ge P,Lu Z,Zhong Y,Li B,Wang J,Zhang L,Zhou D,Li W,Dong W,Pang Y,Gao GF,Liu CH
13-1600 was used in Western Blotting to determine the mechanism by which ubiquitin targets invading microbes to initiate xenophagy.
Mon Apr 29 00:00:00 UTC 2019
Ubiquitin-specific peptidase 2a (USP2a) deubiquitinates and stabilizes β-catenin.
American journal of cancer research
Kim J,Alavi Naini F,Sun Y,Ma L
Thu Oct 01 00:00:00 UTC 2020
Regulation of the ubiquitylation and deubiquitylation of CREB-binding protein modulates histone acetylation and lung inflammation.
Science signaling
Wei J,Dong S,Bowser RK,Khoo A,Zhang L,Jacko AM,Zhao Y,Zhao J
13-1600 was used in Western Blotting to delineate the molecular mechanisms through which CREB-binding protein stability is regulated by FBXenopus laevis19 and USP14.
Tue Jun 13 00:00:00 UTC 2017
Fbxl18 targets LRRK2 for proteasomal degradation and attenuates cell toxicity.
Neurobiology of disease
Ding X,Barodia SK,Ma L,Goldberg MS
131600 was used in western blot to study LRRK2 polymorphisms associated with Parkinson's disease
Wed Feb 01 00:00:00 UTC 2017
Post-translational modifications of Annexin A2 are linked to its association with perinuclear nonpolysomal mRNP complexes.
FEBS open bio
Aukrust I,Rosenberg LA,Ankerud MM,Bertelsen V,Hollås H,Saraste J,Grindheim AK,Vedeler A
131600 was used in western blot to investigate the role of Ser25 phosphorylation in subcellular localization of Annexin A2 and its interaction with mRNP complexes
Wed Feb 01 00:00:00 UTC 2017
The E3 ligase Mule protects the heart against oxidative stress and mitochondrial dysfunction through Myc-dependent inactivation of Pgc-1α and Pink1.
Scientific reports
Dadson K,Hauck L,Hao Z,Grothe D,Rao V,Mak TW,Billia F
131600 was used in western blot to find the E3 ubiquitin ligase Mule is essential for cardiac homeostasis by regulating mitochondrial function via maintenance of Pgc-1alpha and Pink1 expression and persistent negative regulation of c-Myc
Thu Feb 02 00:00:00 UTC 2017
Cycloheximide promotes paraptosis induced by inhibition of cyclophilins in glioblastoma multiforme.
Cell death & disease
Wang L,Gundelach JH,Bram RJ
13-1600 was used in Western Blotting to provide new insights into the mechanisms underlying paraptosis.
Thu May 18 00:00:00 UTC 2017
Cycloheximide promotes paraptosis induced by inhibition of cyclophilins in glioblastoma multiforme.
Cell death & disease
Wang L,Gundelach JH,Bram RJ
13-1600 was used in Western Blotting to provide new insights into the mechanisms underlying paraptosis.
Thu May 18 00:00:00 UTC 2017
Small chaperons and autophagy protected neurons from necrotic cell death.
Scientific reports
Lei Y,Liu K,Hou L,Ding L,Li Y,Liu L
13-1600 was used in Immunocytochemistry-immunoflourescence to perform genetic screening and identify a suppressor of neuronal necrosis, which encodes a seryl-tRNA synthetase.
Tue Jul 18 00:00:00 UTC 2017
Small chaperons and autophagy protected neurons from necrotic cell death.
Scientific reports
Lei Y,Liu K,Hou L,Ding L,Li Y,Liu L
13-1600 was used in Immunocytochemistry-immunoflourescence to perform genetic screening and identify a suppressor of neuronal necrosis, which encodes a seryl-tRNA synthetase.
Tue Jul 18 00:00:00 UTC 2017
Cardiac-specific ablation of the E3 ubiquitin ligase Mdm2 leads to oxidative stress, broad mitochondrial deficiency and early death.
PloS one
Hauck L,Stanley-Hasnain S,Fung A,Grothe D,Rao V,Mak TW,Billia F
13-1600 was used in Western Blot to study the role of Mdm2 in cardiac growth via regulation of p53, the Pgc-1 family and Pink1.
Tue Jan 16 00:00:00 UTC 2018
Multiple myeloma-derived MMP-13 mediates osteoclast fusogenesis and osteolytic disease.
The Journal of clinical investigation
Fu J,Li S,Feng R,Ma H,Sabeh F,Roodman GD,Wang J,Robinson S,Guo XE,Lund T,Normolle D,Mapara MY,Weiss SJ,Lentzsch S
13-1600 was used in Western Blotting to identify pro-osteoclastogenic agents that could potentially serve as therapeutic targets for ameliorating multiple myeloma-associated bone disease.
Mon May 02 00:00:00 UTC 2016
Drosophila Mitf regulates the V-ATPase and the lysosomal-autophagic pathway.
Autophagy
Bouché V,Espinosa AP,Leone L,Sardiello M,Ballabio A,Botas J
13-1600 was used in immunocytochemistry to analyze regulation of V-ATPase and the lysosomal-autophagic pathway by Drosophila Mitf
Mon Dec 26 00:00:00 UTC 2016
Drosophila Mitf regulates the V-ATPase and the lysosomal-autophagic pathway.
Autophagy
Bouché V,Espinosa AP,Leone L,Sardiello M,Ballabio A,Botas J
13-1600 was used in immunocytochemistry to analyze regulation of V-ATPase and the lysosomal-autophagic pathway by Drosophila Mitf
Mon Dec 26 00:00:00 UTC 2016
Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria.
Proceedings of the National Academy of Sciences of the United States of America
Richter B,Sliter DA,Herhaus L,Stolz A,Wang C,Beli P,Zaffagnini G,Wild P,Martens S,Wagner SA,Youle RJ,Dikic I
Published figure using Ubiquitin monoclonal antibody (Product # 13-1600) in Western Blot
Tue Apr 12 00:00:00 UTC 2016
Optineurin deficiency in mice is associated with increased sensitivity to Salmonella but does not affect proinflammatory NF-κB signaling.
European journal of immunology
Slowicka K,Vereecke L,Mc Guire C,Sze M,Maelfait J,Kolpe A,Saelens X,Beyaert R,van Loo G
13-1600 was used in immunohistochemistry - paraffin section to assess an increase in sensitivity to Salmonella but no affect to proinflammatory NF-kappaB signaling by optineurin deficiency in mice
Fri Apr 01 00:00:00 UTC 2016
Reactive oxygen species exert opposite effects on Tyr23 phosphorylation of the nuclear and cortical pools of annexin A2.
Journal of cell science
Grindheim AK,Hollås H,Raddum AM,Saraste J,Vedeler A
Fri Jan 15 00:00:00 UTC 2016
Comparison of mHTT Antibodies in Huntington's Disease Mouse Models Reveal Specific Binding Profiles and Steady-State Ubiquitin Levels with Disease Development.
PloS one
Bayram-Weston Z,Jones L,Dunnett SB,Brooks SP
13-1600 was used in immunohistochemistry - frozen section to utilize a Huntington's disease mouse model to show specific binding profiles and steady-state ubiquitin levels with disease development when comparing mHTT antibodies
Fri Jul 14 00:00:00 UTC 2017
Aberrant Splicing Promotes Proteasomal Degradation of L-type CaV1.2 Calcium Channels by Competitive Binding for CaVβ Subunits in Cardiac Hypertrophy.
Scientific reports
Hu Z,Wang JW,Yu D,Soon JL,de Kleijn DP,Foo R,Liao P,Colecraft HM,Soong TW
131600 was used in western blot to propose that neonatal splice variant of CaV1.2 channels contribute to heart disease
Wed Oct 12 00:00:00 UTC 2016
NQO1 inhibits proteasome-mediated degradation of HIF-1α.
Nature communications
Oh ET,Kim JW,Kim JM,Kim SJ,Lee JS,Hong SS,Goodwin J,Ruthenborg RJ,Jung MG,Lee HJ,Lee CH,Park ES,Kim C,Park HJ
131600 was used in western blot to describe a function for NQO1 in stabilizing HIF-1alpha
Wed Dec 14 00:00:00 UTC 2016
The cell cycle regulator 14-3-3σ opposes and reverses cancer metabolic reprogramming.
Nature communications
Phan L,Chou PC,Velazquez-Torres G,Samudio I,Parreno K,Huang Y,Tseng C,Vu T,Gully C,Su CH,Wang E,Chen J,Choi HH,Fuentes-Mattei E,Shin JH,Shiang C,Grabiner B,Blonska M,Skerl S,Shao Y,Cody D,Delacerda J,Kingsley C,Webb D,Carlock C,Zhou Z,Hsieh YC,Lee J,Elliott A,Ramirez M,Bankson J,Hazle J,Wang Y,Li L,Weng S,Rizk N,Wen YY,Lin X,Wang H,Wang H,Zhang A,Xia X,Wu Y,Habra M,Yang W,Pusztai L,Yeung SC,Lee MH
13-1600 was used in western blot to study the role of 14-3-3sigma in tumor metabolism
Thu Jul 16 00:00:00 UTC 2015
Identification of a subnuclear body involved in sequence-specific cytokine RNA processing.
Nature communications
Lee S,Lee TA,Lee E,Kang S,Park A,Kim SW,Park HJ,Yoon JH,Ha SJ,Park T,Lee JS,Cheon JH,Park B
13-1600 was used in immunocytochemistry and immunohistochemistry - paraffin section to report that Tat-activating regulatory DNA-binding protein-43 regulates the synthesis of the interleukin-6 and -10 splicing activating compartment
Mon Jan 05 00:00:00 UTC 2015
mRNA 3'-UTR shortening is a molecular signature of mTORC1 activation.
Nature communications
Chang JW,Zhang W,Yeh HS,de Jong EP,Jun S,Kim KH,Bae SS,Beckman K,Hwang TH,Kim KS,Kim DH,Griffin TJ,Kuang R,Yong J
13-1600 was used in Western Blotting to identify a previously uncharacterized role for mTOR in the selective regulation of protein synthesis by modulating 3'-UTR length of mRNAs.
Mon Jun 15 00:00:00 UTC 2015
Ubiquitin-dependent regulation of MEKK2/3-MEK5-ERK5 signaling module by XIAP and cIAP1.
The EMBO journal
Takeda AN,Oberoi-Khanuja TK,Glatz G,Schulenburg K,Scholz RP,Carpy A,Macek B,Remenyi A,Rajalingam K
Mon Aug 18 00:00:00 UTC 2014
CSN6 drives carcinogenesis by positively regulating Myc stability.
Nature communications
Chen J,Shin JH,Zhao R,Phan L,Wang H,Xue Y,Post SM,Ho Choi H,Chen JS,Wang E,Zhou Z,Tseng C,Gully C,Velazquez-Torres G,Fuentes-Mattei E,Yeung G,Qiao Y,Chou PC,Su CH,Hsieh YC,Hsu SL,Ohshiro K,Shaikenov T,Wang H,Yeung SC,Lee MH
13-1600 was used in western blot to identify the mechanistic link between Cullin neddylation and Myc ubiquitination/degradation
Fri Nov 14 00:00:00 UTC 2014
SLAP displays tumour suppressor functions in colorectal cancer via destabilization of the SRC substrate EPHA2.
Nature communications
Naudin C,Sirvent A,Leroy C,Larive R,Simon V,Pannequin J,Bourgaux JF,Pierre J,Robert B,Hollande F,Roche S
13-1600 was used in western blot to demonstrate a tumor-suppressive role for SLAP in colorectal cancer.
Mon Mar 07 00:00:00 UTC 2016
Monoclonal antibody against the ectodomain of E-cadherin (DECMA-1) suppresses breast carcinogenesis: involvement of the HER/PI3K/Akt/mTOR and IAP pathways.
Clinical cancer research : an official journal of the American Association for Cancer Research
Brouxhon SM,Kyrkanides S,Teng X,Raja V,O'Banion MK,Clarke R,Byers S,Silberfeld A,Tornos C,Ma L
13-1600 was used in western blot to test if targeting the ectodomain of E-cadherin is an effective treatment of HER2-positive breast cancers.
Sat Jun 15 00:00:00 UTC 2013
Drosophila Fip200 is an essential regulator of autophagy that attenuates both growth and aging.
Autophagy
Kim M,Park HL,Park HW,Ro SH,Nam SG,Reed JM,Guan JL,Lee JH
Thu Aug 01 00:00:00 UTC 2013
Drosophila Fip200 is an essential regulator of autophagy that attenuates both growth and aging.
Autophagy
Kim M,Park HL,Park HW,Ro SH,Nam SG,Reed JM,Guan JL,Lee JH
Thu Aug 01 00:00:00 UTC 2013
Dissecting the pathways that destabilize mutant p53: the proteasome or autophagy?
Cell cycle (Georgetown, Tex.)
Choudhury S,Kolukula VK,Preet A,Albanese C,Avantaggiati ML
13-1600 was used in western blot to elucidate mechanisms that control stability of p53 mutants.
Mon Apr 01 00:00:00 UTC 2013
Selective monitoring of ubiquitin signals with genetically encoded ubiquitin chain-specific sensors.
Nature protocols
van Wijk SJ,Fiškin E,Dikic I
13-1600 was used in Western Blot to selectively detect, visualize and inhibit Ub-dependent processes in mammalian cells as currently, there is a lack of methodology for visualizing endogenous ubiquitination in living cells.
Tue Jan 14 00:00:00 UTC 2014
Optineurin is colocalized with ubiquitin in Marinesco bodies.
Acta neuropathologica
Schwab C,Yu S,McGeer PL
13-1600 was used in immunohistochemistry to show that optineurin colocalizes with ubiquitin in Marinesco bodies.
Wed Feb 01 00:00:00 UTC 2012
Mitochondrial division ensures the survival of postmitotic neurons by suppressing oxidative damage.
The Journal of cell biology
Kageyama Y,Zhang Z,Roda R,Fukaya M,Wakabayashi J,Wakabayashi N,Kensler TW,Reddy PH,Iijima M,Sesaki H
Mon May 14 00:00:00 UTC 2012
Gene expression levels assessed by CA1 pyramidal neuron and regional hippocampal dissections in Alzheimer's disease.
Neurobiology of disease
Ginsberg SD,Alldred MJ,Che S
13-1600 was used in immunohistochemistry to evaluate molecular signatures of an individual cell types in patients with of Alzheimer's disease.
Sun Jan 01 00:00:00 UTC 2012
Dietary downregulation of mutant p53 levels via glucose restriction: mechanisms and implications for tumor therapy.
Cell cycle (Georgetown, Tex.)
Rodriguez OC,Choudhury S,Kolukula V,Vietsch EE,Catania J,Preet A,Reynoso K,Bargonetti J,Wellstein A,Albanese C,Avantaggiati ML
Published figure using Ubiquitin monoclonal antibody (Product # 13-1600) in Western Blot
Sat Dec 01 00:00:00 UTC 2012
Analysis of nuclear factor-κB (NF-κB) essential modulator (NEMO) binding to linear and lysine-linked ubiquitin chains and its role in the activation of NF-κB.
The Journal of biological chemistry
Kensche T,Tokunaga F,Ikeda F,Goto E,Iwai K,Dikic I
13-1600 was used in western blot to elucidate NEMO binding to linear ubiquitin chains of different lengths.
Fri Jul 06 00:00:00 UTC 2012
Analysis of nuclear factor-κB (NF-κB) essential modulator (NEMO) binding to linear and lysine-linked ubiquitin chains and its role in the activation of NF-κB.
The Journal of biological chemistry
Kensche T,Tokunaga F,Ikeda F,Goto E,Iwai K,Dikic I
13-1600 was used in western blot to elucidate NEMO binding to linear ubiquitin chains of different lengths.
Fri Jul 06 00:00:00 UTC 2012
An intrinsically disordered region of the acetyltransferase p300 with similarity to prion-like domains plays a role in aggregation.
PloS one
Kirilyuk A,Shimoji M,Catania J,Sahu G,Pattabiraman N,Giordano A,Albanese C,Mocchetti I,Toretsky JA,Uversky VN,Avantaggiati ML
13-1600 was used in immunocytochemistry, immunohistochemistry, and western blot to investigate how p300 affects protein aggregation
Tue May 07 00:00:00 UTC 2013
An intrinsically disordered region of the acetyltransferase p300 with similarity to prion-like domains plays a role in aggregation.
PloS one
Kirilyuk A,Shimoji M,Catania J,Sahu G,Pattabiraman N,Giordano A,Albanese C,Mocchetti I,Toretsky JA,Uversky VN,Avantaggiati ML
13-1600 was used in immunocytochemistry, immunohistochemistry, and western blot to investigate how p300 affects protein aggregation
Tue May 07 00:00:00 UTC 2013
Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers.
The Journal of clinical investigation
Zhao R,Yeung SC,Chen J,Iwakuma T,Su CH,Chen B,Qu C,Zhang F,Chen YT,Lin YL,Lee DF,Jin F,Zhu R,Shaikenov T,Sarbassov D,Sahin A,Wang H,Wang H,Lai CC,Tsai FJ,Lozano G,Lee MH
Published figure using Ubiquitin monoclonal antibody (Product # 13-1600) in Western Blot
Tue Mar 01 00:00:00 UTC 2011
Amyloid precursor-like protein 2 cleavage contributes to neuronal intranuclear inclusions and cytotoxicity in spinocerebellar ataxia-7 (SCA7).
Neurobiology of disease
Takahashi-Fujigasaki J,Breidert T,Fujigasaki H,Duyckaerts C,Camonis JH,Brice A,Lebre AS
13-1600 was used in immunocytochemistry and immunohistochemistry to identify amyloid precursor-like protein 2 as a partner protein for ataxin-7
Sat Jan 01 00:00:00 UTC 2011
Protein interactions among Fe65, the low-density lipoprotein receptor-related protein, and the amyloid precursor protein.
Biochemistry
Mulvihill MM,Guttman M,Komives EA
13-1600 was used in Western Blotting to investigate the binding among Fe65, the low-density lipoprotein receptor-related protein, and the amyloid precursor protein.
Tue Jul 19 00:00:00 UTC 2011
Synaptic dysbindin-1 reductions in schizophrenia occur in an isoform-specific manner indicating their subsynaptic location.
PloS one
Talbot K,Louneva N,Cohen JW,Kazi H,Blake DJ,Arnold SE
13-1600 was used in Immunohistochemistry to determine whether the synaptic reductions in dysbindin-1 levels in schizophrenia patients are isoform specific.
Tue Mar 01 00:00:00 UTC 2011
A photoconvertible fluorescent reporter to track chaperone-mediated autophagy.
Nature communications
Koga H,Martinez-Vicente M,Macian F,Verkhusha VV,Cuervo AM
13-1600 was used in Immunocytochemistry-immunoflourescence to develop a photoconvertible fluorescent reporter to track chaperone-mediated autophagy in living cells.
Tue Jul 12 00:00:00 UTC 2011
Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines.
Nature immunology
Tseng PH,Matsuzawa A,Zhang W,Mino T,Vignali DA,Karin M
Published figure using Ubiquitin monoclonal antibody (Product # 13-1600) in Immunoprecipitation
Fri Jan 01 00:00:00 UTC 2010
Psh1 is an E3 ubiquitin ligase that targets the centromeric histone variant Cse4.
Molecular cell
Hewawasam G,Shivaraju M,Mattingly M,Venkatesh S,Martin-Brown S,Florens L,Workman JL,Gerton JL
13-1600 was used in Western Blotting to suggest Psh1 functions to prevent the mislocalization of Cse4.
Fri Nov 12 00:00:00 UTC 2010
Psh1 is an E3 ubiquitin ligase that targets the centromeric histone variant Cse4.
Molecular cell
Hewawasam G,Shivaraju M,Mattingly M,Venkatesh S,Martin-Brown S,Florens L,Workman JL,Gerton JL
13-1600 was used in Western Blotting to suggest Psh1 functions to prevent the mislocalization of Cse4.
Fri Nov 12 00:00:00 UTC 2010
SCA1-like disease in mice expressing wild-type ataxin-1 with a serine to aspartic acid replacement at residue 776.
Neuron
Duvick L,Barnes J,Ebner B,Agrawal S,Andresen M,Lim J,Giesler GJ,Zoghbi HY,Orr HT
13-1600 was used in immunohistochemistry to test if phosphorylation of ATXN1 at Ser776 is important for pathogenesis of SCA1
Thu Sep 23 00:00:00 UTC 2010
Neurodegeneration by polyglutamine Atrophin is not rescued by induction of autophagy.
Cell death and differentiation
Nisoli I,Chauvin JP,Napoletano F,Calamita P,Zanin V,Fanto M,Charroux B
13-1600 was used in immunohistochemistry to explore the role of autophaghy in a Drosophila model of Dentatorubral-pallidoluysian Atrophy
Fri Oct 01 00:00:00 UTC 2010
Chemical genetics approach to restoring p27Kip1 reveals novel compounds with antiproliferative activity in prostate cancer cells.
BMC biology
Rico-Bautista E,Yang CC,Lu L,Roth GP,Wolf DA
13-1600 was used in western blot to test if small molecules can restore p27 expression in cancer cells
Thu Dec 23 00:00:00 UTC 2010
IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome.
The Journal of cell biology
Thompson LM,Aiken CT,Kaltenbach LS,Agrawal N,Illes K,Khoshnan A,Martinez-Vincente M,Arrasate M,O'Rourke JG,Khashwji H,Lukacsovich T,Zhu YZ,Lau AL,Massey A,Hayden MR,Zeitlin SO,Finkbeiner S,Green KN,LaFerla FM,Bates G,Huang L,Patterson PH,Lo DC,Cuervo AM,Marsh JL,Steffan JS
13-1600 was used in Western Blotting to examine the role of IKK in enhancing the normal clearance of Huntingtin by the proteasome and lysosome.
Mon Dec 28 00:00:00 UTC 2009
Interactions of the NPXY microdomains of the low density lipoprotein receptor-related protein 1.
Proteomics
Guttman M,Betts GN,Barnes H,Ghassemian M,van der Geer P,Komives EA
13-1600 was used in western blot to identify proteins that bind phosphorylated and unphosphorylated LRP1
Sun Nov 01 00:00:00 UTC 2009
Autophagy in load-induced heart disease.
Methods in enzymology
Zhu H,Rothermel BA,Hill JA
13-1600 was used in immunohistochemistry to discuss methods to assess the contribution of cardiomyocyte autophagy to ventricular remodeling and disease pathogenesis
Thu Apr 02 00:00:00 UTC 2009
Thioredoxin-related Protein 32 is an arsenite-regulated Thiol Reductase of the proteasome 19 S particle.
The Journal of biological chemistry
Wiseman RL,Chin KT,Haynes CM,Stanhill A,Xu CF,Roguev A,Krogan NJ,Neubert TA,Ron D
13-1600 was used in western blot to identify TRP32 as a subunit of the 26 S proteasome
Fri May 29 00:00:00 UTC 2009
Early-onset and robust amyloid pathology in a new homozygous mouse model of Alzheimer's disease.
PloS one
Willuweit A,Velden J,Godemann R,Manook A,Jetzek F,Tintrup H,Kauselmann G,Zevnik B,Henriksen G,Drzezga A,Pohlner J,Schoor M,Kemp JA,von der Kammer H
Fri Nov 20 00:00:00 UTC 2009
The NER protein Rad33 shows functional homology to human Centrin2 and is involved in modification of Rad4.
DNA repair
den Dulk B,van Eijk P,de Ruijter M,Brandsma JA,Brouwer J
13-1600 was used in western blot to study the relationship between Rad33 and the Rad4-Rad23 during DNA repair
Sun Jun 01 00:00:00 UTC 2008
Regulation of mitochondrial morphology by USP30, a deubiquitinating enzyme present in the mitochondrial outer membrane.
Molecular biology of the cell
Nakamura N,Hirose S
13-1600 was used in western blot to identify deubiquitinating enzymes participate in regulating mitochondrial dynamics in mammalian cells
Thu May 01 00:00:00 UTC 2008
Rapid identification of differentiation markers from whole epithelial cells by matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry and statistical analysis.
Rapid communications in mass spectrometry : RCM
Marvin-Guy LF,Duncan P,Wagnière S,Antille N,Porta N,Affolter M,Kussmann M
13-1600 was used in immunocytochemistry to identify markers for cellular differentiation
Tue Apr 01 00:00:00 UTC 2008
Kinase MEKK1 is required for CD40-dependent activation of the kinases Jnk and p38, germinal center formation, B cell proliferation and antibody production.
Nature immunology
Gallagher E,Enzler T,Matsuzawa A,Anzelon-Mills A,Otero D,Holzer R,Janssen E,Gao M,Karin M
13-1600 was used in western blot to show that MEKK1 is required for thymus-dependent antigen-induced B cell proliferation and antibody production
Mon Jan 01 00:00:00 UTC 2007
PDLIM2-mediated termination of transcription factor NF-kappaB activation by intranuclear sequestration and degradation of the p65 subunit.
Nature immunology
Tanaka T,Grusby MJ,Kaisho T
13-1600 was used in western blot to show that PDLIM2 negatively regulates NF-kappaB activity
Fri Jun 01 00:00:00 UTC 2007
Geldanamycin induces G2 arrest in U87MG glioblastoma cells through downregulation of Cdc2 and cyclin B1.
Biochemical pharmacology
Nomura N,Nomura M,Newcomb EW,Zagzag D
13-1600 was used in western blot to assess geldanamycin-induced cell cycle regulation in glioblastoma cells
Tue May 15 00:00:00 UTC 2007
Allosteric activation of human glucokinase by free polyubiquitin chains and its ubiquitin-dependent cotranslational proteasomal degradation.
The Journal of biological chemistry
Bjørkhaug L,Molnes J,Søvik O,Njølstad PR,Flatmark T
13-1600 was used in western blot to characterize human glucokinase isoforms
Fri Aug 03 00:00:00 UTC 2007
Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change.
Proceedings of the National Academy of Sciences of the United States of America
Gallagher E,Gao M,Liu YC,Karin M
Tue Feb 07 00:00:00 UTC 2006
RhoB facilitates c-Myc turnover by supporting efficient nuclear accumulation of GSK-3.
Oncogene
Huang M,Kamasani U,Prendergast GC
Thu Mar 02 00:00:00 UTC 2006
Methylation silencing of SOCS-3 promotes cell growth and migration by enhancing JAK/STAT and FAK signalings in human hepatocellular carcinoma.
Oncogene
Niwa Y,Kanda H,Shikauchi Y,Saiura A,Matsubara K,Kitagawa T,Yamamoto J,Kubo T,Yoshikawa H
Thu Sep 22 00:00:00 UTC 2005
Histomathematical analysis of clinical specimens: challenges and progress.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Gannot G,Gillespie JW,Chuaqui RF,Tangrea MA,Linehan WM,Emmert-Buck MR
Tue Feb 01 00:00:00 UTC 2005
Geldanamycin-induced degradation of Chk1 is mediated by proteasome.
Biochemical and biophysical research communications
Nomura M,Nomura N,Yamashita J
13-1600 was used in western blot to investigate the mechanisms of Chk1 regulation in glioblastoma cells using geldanamycin
Fri Sep 30 00:00:00 UTC 2005
Experimental tests to definitively determine ubiquitylation of a substrate.
Methods in enzymology
Bloom J,Pagano M
13-1600 was used in western blot discuss methods to study protein ubiquitylation
Thu May 31 00:00:00 UTC 2007
Involvement of the p97-Ufd1-Npl4 complex in the regulated endoplasmic reticulum-associated degradation of inositol 1,4,5-trisphosphate receptors.
The Journal of biological chemistry
Alzayady KJ,Panning MM,Kelley GG,Wojcikiewicz RJ
Fri Oct 14 00:00:00 UTC 2005
Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans.
The Journal of biological chemistry
Ved R,Saha S,Westlund B,Perier C,Burnam L,Sluder A,Hoener M,Rodrigues CM,Alfonso A,Steer C,Liu L,Przedborski S,Wolozin B
Fri Dec 30 00:00:00 UTC 2005
Defining the role of ubiquitin-interacting motifs in the polyglutamine disease protein, ataxin-3.
The Journal of biological chemistry
Berke SJ,Chai Y,Marrs GL,Wen H,Paulson HL
Fri Sep 09 00:00:00 UTC 2005
Defining the role of ubiquitin-interacting motifs in the polyglutamine disease protein, ataxin-3.
The Journal of biological chemistry
Berke SJ,Chai Y,Marrs GL,Wen H,Paulson HL
Fri Sep 09 00:00:00 UTC 2005
Role of p97 AAA-ATPase in the retrotranslocation of the cholera toxin A1 chain, a non-ubiquitinated substrate.
The Journal of biological chemistry
Kothe M,Ye Y,Wagner JS,De Luca HE,Kern E,Rapoport TA,Lencer WI
Fri Jul 29 00:00:00 UTC 2005
A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells.
Nature cell biology
Yeh E,Cunningham M,Arnold H,Chasse D,Monteith T,Ivaldi G,Hahn WC,Stukenberg PT,Shenolikar S,Uchida T,Counter CM,Nevins JR,Means AR,Sears R
Thu Apr 01 00:00:00 UTC 2004
A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells.
Nature cell biology
Yeh E,Cunningham M,Arnold H,Chasse D,Monteith T,Ivaldi G,Hahn WC,Stukenberg PT,Shenolikar S,Uchida T,Counter CM,Nevins JR,Means AR,Sears R
Thu Apr 01 00:00:00 UTC 2004
A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells.
Nature cell biology
Yeh E,Cunningham M,Arnold H,Chasse D,Monteith T,Ivaldi G,Hahn WC,Stukenberg PT,Shenolikar S,Uchida T,Counter CM,Nevins JR,Means AR,Sears R
Thu Apr 01 00:00:00 UTC 2004
A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells.
Nature cell biology
Yeh E,Cunningham M,Arnold H,Chasse D,Monteith T,Ivaldi G,Hahn WC,Stukenberg PT,Shenolikar S,Uchida T,Counter CM,Nevins JR,Means AR,Sears R
Thu Apr 01 00:00:00 UTC 2004
Proteasome mediates dopaminergic neuronal degeneration, and its inhibition causes alpha-synuclein inclusions.
The Journal of biological chemistry
Sawada H,Kohno R,Kihara T,Izumi Y,Sakka N,Ibi M,Nakanishi M,Nakamizo T,Yamakawa K,Shibasaki H,Yamamoto N,Akaike A,Inden M,Kitamura Y,Taniguchi T,Shimohama S
Fri Mar 12 00:00:00 UTC 2004
Distinct steps in dislocation of luminal endoplasmic reticulum-associated degradation substrates: roles of endoplamic reticulum-bound p97/Cdc48p and proteasome.
The Journal of biological chemistry
Elkabetz Y,Shapira I,Rabinovich E,Bar-Nun S
Fri Feb 06 00:00:00 UTC 2004
Distinct steps in dislocation of luminal endoplasmic reticulum-associated degradation substrates: roles of endoplamic reticulum-bound p97/Cdc48p and proteasome.
The Journal of biological chemistry
Elkabetz Y,Shapira I,Rabinovich E,Bar-Nun S
Fri Feb 06 00:00:00 UTC 2004
Distinct steps in dislocation of luminal endoplasmic reticulum-associated degradation substrates: roles of endoplamic reticulum-bound p97/Cdc48p and proteasome.
The Journal of biological chemistry
Elkabetz Y,Shapira I,Rabinovich E,Bar-Nun S
Fri Feb 06 00:00:00 UTC 2004
Distinct steps in dislocation of luminal endoplasmic reticulum-associated degradation substrates: roles of endoplamic reticulum-bound p97/Cdc48p and proteasome.
The Journal of biological chemistry
Elkabetz Y,Shapira I,Rabinovich E,Bar-Nun S
Fri Feb 06 00:00:00 UTC 2004
Acquired FANCA dysfunction and cytogenetic instability in adult acute myelogenous leukemia.
Blood
Lensch MW,Tischkowitz M,Christianson TA,Reifsteck CA,Speckhart SA,Jakobs PM,O'Dwyer ME,Olson SB,Le Beau MM,Hodgson SV,Mathew CG,Larson RA,Bagby GC
13-1600 was used in immunoprecipitation to assess if acquired Fanconi anemia protein dysfunction contributes to cytogenetic instability in secondary acute myelogenous leukemia cells.
Tue Jul 01 00:00:00 UTC 2003
Acquired FANCA dysfunction and cytogenetic instability in adult acute myelogenous leukemia.
Blood
Lensch MW,Tischkowitz M,Christianson TA,Reifsteck CA,Speckhart SA,Jakobs PM,O'Dwyer ME,Olson SB,Le Beau MM,Hodgson SV,Mathew CG,Larson RA,Bagby GC
13-1600 was used in immunoprecipitation to assess if acquired Fanconi anemia protein dysfunction contributes to cytogenetic instability in secondary acute myelogenous leukemia cells.
Tue Jul 01 00:00:00 UTC 2003
Conformational change and mitochondrial translocation of Bax accompany proteasome inhibitor-induced apoptosis of chronic lymphocytic leukemic cells.
Oncogene
Dewson G,Snowden RT,Almond JB,Dyer MJ,Cohen GM
Thu May 01 00:00:00 UTC 2003
Conformational change and mitochondrial translocation of Bax accompany proteasome inhibitor-induced apoptosis of chronic lymphocytic leukemic cells.
Oncogene
Dewson G,Snowden RT,Almond JB,Dyer MJ,Cohen GM
Thu May 01 00:00:00 UTC 2003
blue cheese mutations define a novel, conserved gene involved in progressive neural degeneration.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Finley KD,Edeen PT,Cumming RC,Mardahl-Dumesnil MD,Taylor BJ,Rodriguez MH,Hwang CE,Benedetti M,McKeown M
Sat Feb 15 00:00:00 UTC 2003
blue cheese mutations define a novel, conserved gene involved in progressive neural degeneration.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Finley KD,Edeen PT,Cumming RC,Mardahl-Dumesnil MD,Taylor BJ,Rodriguez MH,Hwang CE,Benedetti M,McKeown M
Sat Feb 15 00:00:00 UTC 2003
Regulation of the ubiquitin-conjugating enzyme hHR6A by CDK-mediated phosphorylation.
The EMBO journal
Sarcevic B,Mawson A,Baker RT,Sutherland RL
Published figure using Ubiquitin monoclonal antibody (Product # 13-1600) in Western Blot
Mon Apr 15 00:00:00 UTC 2002
Immunohistochemical study of p53-associated proteins in rat brain following lithium-pilocarpine status epilepticus.
Brain research
Tan Z,Sankar R,Tu W,Shin D,Liu H,Wasterlain CG,Schreiber SS
13-1600 was used in immunohistochemistry to identify proteins induced by lithium-pilocarpine-mediated status epilepticus
Fri Mar 01 00:00:00 UTC 2002
Inhibition of Src family kinases blocks epidermal growth factor (EGF)-induced activation of Akt, phosphorylation of c-Cbl, and ubiquitination of the EGF receptor.
The Journal of biological chemistry
Kassenbrock CK,Hunter S,Garl P,Johnson GL,Anderson SM
13-1600 was used in western blot to investigate cellular changes when T47D cells are treated with epidermal growth factor.
Fri Jul 12 00:00:00 UTC 2002
Inhibition of Src family kinases blocks epidermal growth factor (EGF)-induced activation of Akt, phosphorylation of c-Cbl, and ubiquitination of the EGF receptor.
The Journal of biological chemistry
Kassenbrock CK,Hunter S,Garl P,Johnson GL,Anderson SM
13-1600 was used in western blot to investigate cellular changes when T47D cells are treated with epidermal growth factor.
Fri Jul 12 00:00:00 UTC 2002
Ubiquitylation of BAG-1 suggests a novel regulatory mechanism during the sorting of chaperone substrates to the proteasome.
The Journal of biological chemistry
Alberti S,Demand J,Esser C,Emmerich N,Schild H,Hohfeld J
13-1600 was used in immunoprecipitation to report that BAG-1 is a substrate of the CHIP ubiquitin ligase in vitro and in vivo
Fri Nov 29 00:00:00 UTC 2002
Interferon-gamma-mediated activation and ubiquitin-proteasome-dependent degradation of PPARgamma in adipocytes.
The Journal of biological chemistry
Floyd ZE,Stephens JM
13-1600 was used in western blot to show that IFNgamma treatment results in increased targeting of PPARgamma to the ubiquitin-proteasome system.
Fri Feb 08 00:00:00 UTC 2002
Cancer-predisposing mutations within the RING domain of BRCA1: loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity.
Proceedings of the National Academy of Sciences of the United States of America
Ruffner H,Joazeiro CA,Hemmati D,Hunter T,Verma IM
13-1600 was used in western blot to report that BRCA has ubiquitin protein ligase activity and that cancer-predisposing mutations within the BRCA RING domain abolish its ubiquitin ligase activity.
Tue Apr 24 00:00:00 UTC 2001
Proteasomes regulate erythropoietin receptor and signal transducer and activator of transcription 5 (STAT5) activation. Possible involvement of the ubiquitinated Cis protein.
The Journal of biological chemistry
Verdier F,Chrétien S,Muller O,Varlet P,Yoshimura A,Gisselbrecht S,Lacombe C,Mayeux P
13-1600 was used in western blot to study the relationship between ubiquitinated Cis and the erythropoietin receptor.
Fri Oct 23 00:00:00 UTC 1998
The Ras-specific exchange factors mouse Sos1 (mSos1) and mSos2 are regulated differently: mSos2 contains ubiquitination signals absent in mSos1.
Molecular and cellular biology
Nielsen KH,Papageorge AG,Vass WC,Willumsen BM,Lowy DR
13-1600 was used in immunoprecipitation to characterize mouse msos and msos2.
Mon Dec 01 00:00:00 UTC 1997
Identification of a neural alpha-catenin as a key regulator of cadherin function and multicellular organization.
Cell
Hirano S,Kimoto N,Shimoyama Y,Hirohashi S,Takeichi M
Fri Jul 24 00:00:00 UTC 1992
Identification of a neural alpha-catenin as a key regulator of cadherin function and multicellular organization.
Cell
Hirano S,Kimoto N,Shimoyama Y,Hirohashi S,Takeichi M
Fri Jul 24 00:00:00 UTC 1992
Identification of a neural alpha-catenin as a key regulator of cadherin function and multicellular organization.
Cell
Hirano S,Kimoto N,Shimoyama Y,Hirohashi S,Takeichi M
Fri Jul 24 00:00:00 UTC 1992
