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Product Details
BS-2786R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human UCN3, amino acids 120-157.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Urocortin 3 (UCN3) is a member of the corticotropin-releasing factor (CRF) family, encoded by the UCN3 gene, and is primarily involved in stress response and energy balance regulation. UCN3 is predominantly expressed in the hypothalamus and certain peripheral tissues, such as pancreatic islets, where it plays significant roles in modulating anxiety-related behaviors and metabolism. This neuropeptide functions by binding to CRF2 receptors, exerting effects on glucose metabolism and insulin secretion. UCN3 has been implicated in protecting the heart from ischemic damage and modulating the cardiovascular system's response to stress, highlighting its potential in treating cardiac disorders. Additionally, it influences nutrient partitioning and energy homeostasis, with expression levels affected by nutritional status. Research indicates that UCN3 deficiency may lead to impaired glucose tolerance and altered energy expenditure, demonstrating its importance in metabolic health. Furthermore, UCN3 has been associated with the regulation of neuroendocrine signaling pathways, providing insights into therapeutic strategies for metabolic and stress-related disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: prepro-urocortin 3; Stresscopin; Ucn III; urocortin 3 (stresscopin); Urocortin II; Urocortin III; Urocortin-3
Gene Aliases: RGD1562213; SCP; SPC; UCN3; UCNIII
UniProt ID: (Human) Q969E3, (Mouse) Q924A4
Entrez Gene ID: (Human) 114131, (Mouse) 83428, (Rat) 498791
response to stress
adenylate cyclase-activating G-protein coupled receptor signaling pathway
neuropeptide signaling pathway
digestion
cellular response to nutrient levels
positive regulation of insulin secretion
positive regulation of membrane potential
response to glucose
response to immobilization stress
response to starvation
response to corticosterone
cellular response to hypoxia
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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