Invitrogen

Urocortin Polyclonal Antibody

1 Reference
View all (4) Urocortin antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-75189

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to amino acids 80-124 of Human UCN.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2718917

Product Specific Information

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Target Information

Urocortin (UCN), a 40 amino acids neuropeptide widely distributed in the central nervous system (CNS), belongs to a family of structurally related peptides including corticotrophin releasing factor (CRF), sauvagine and urotensin I. Urocortin is derived from a larger precursor protein (pro-urocortin, also named corticotensin). Urocortin has biological actions similar to CRF such as stress-related endocrine, autonomic and behavioral responses in mammalian species. It is a potent stimulator of adrenocorticotropic hormone (ACTH) secretion by corticotroph cells from the anterior pituitary in vitro and in vivo.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: Corticotensin; prepro-urocortin; Urocortin; urocortin, preproprotein

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Gene Aliases: Mpv17; UCN; Ucn1; UI; UROC

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UniProt ID: (Human) P55089, (Rat) P55090, (Mouse) P81615

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Entrez Gene ID: (Human) 7349, (Rat) 29151, (Mouse) 22226

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Function(s)
neuropeptide hormone activity protein binding corticotropin-releasing hormone activity histone deacetylase inhibitor activity corticotropin-releasing hormone receptor 1 binding corticotropin-releasing hormone receptor 2 binding G-protein coupled receptor binding hormone activity
Process(es)
positive regulation of protein phosphorylation inflammatory response response to oxidative stress neuropeptide signaling pathway female pregnancy sensory perception of sound learning or memory feeding behavior associative learning aerobic respiration positive regulation of gene expression negative regulation of gene expression pancreatic juice secretion positive regulation of cell growth positive regulation of cAMP biosynthetic process negative regulation of histone deacetylation neuron projection development negative regulation of appetite response to estradiol positive regulation of interleukin-6 production positive regulation of collagen biosynthetic process positive regulation of peptidyl-serine phosphorylation activation of protein kinase A activity social behavior gastric emptying drinking behavior negative regulation of apoptotic process positive regulation of vascular permeability positive regulation of translation positive regulation of DNA replication negative regulation of blood pressure negative regulation of cell size positive regulation of vasodilation negative regulation of hormone secretion response to pain response to glucocorticoid positive regulation of corticotropin secretion regulation of synaptic transmission, glutamatergic positive regulation of cardiac muscle contraction negative regulation of gastric acid secretion negative regulation of necrotic cell death negative regulation of cell death positive regulation of calcium ion import negative regulation of neuron death negative regulation of feeding behavior positive regulation of behavioral fear response startle response G-protein coupled receptor signaling pathway response to auditory stimulus positive regulation of transcription from RNA polymerase II promoter response to immobilization stress response to starvation negative regulation of catalytic activity prepulse inhibition
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