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Invitrogen
Urokinase Recombinant Rabbit Monoclonal Antibody (10E5)
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Urokinase Antibody (MA5-49935) in IHC (P)
Immunohistochemistry analysis with a Urokinase monoclonal antibody (Product # MA5-49935) using a dilution of 1:100 and staining in paraffin-embedded human prostate cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30 min at RT. Then primary antibody (1% BSA) was... View More
Product Details
MA5-49935
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
10E5
Immunogen
A synthesized peptide derived from human Urokinase
Conjugate
Form
Liquid
Concentration
3.1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_3092716
Target Information
This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: antagonist of uPA; CD87; HGNC:9052; plasminogen activator; plasminogen activator, urinary; U-plasminogen activator; UPAR; URKR; Urokinase-type plasminogen activator
Gene Aliases: ATF; BDPLT5; PLAU; QPD; u-PA; UPA; URK
UniProt ID: (Human) P00749
Entrez Gene ID: (Human) 5328
angiogenesis
proteolysis
chemotaxis
signal transduction
spermatogenesis
embryo implantation
blood coagulation
positive regulation of cell proliferation
regulation of receptor activity
response to activity
smooth muscle cell migration
regulation of smooth muscle cell migration
positive regulation of smooth muscle cell migration
positive regulation of cell migration
regulation of cell adhesion mediated by integrin
cellular response to hepatocyte growth factor stimulus
fibrinolysis
skeletal muscle tissue regeneration
response to hyperoxia
positive regulation of ovulation
regulation of wound healing
neuron death
cellular response to lipopolysaccharide
cellular response to glucose stimulus
cellular response to hypoxia
cellular response to fluid shear stress
cellular response to staurosporine
regulation of smooth muscle cell-matrix adhesion
regulation of hepatocyte proliferation
positive regulation of reactive oxygen species metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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