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Invitrogen
Uromodulin Monoclonal Antibody (774056)
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.jpg?time=20250104 "Uromodulin Antibody in Immunohistochemistry (Frozen) (IHC (F))")
FIGURE: 1 / 3
Uromodulin Antibody (MA5-24374) in IHC (F)
Immunohistochemical analysis of Uromodulin was detected in immersion fixed frozen sections of mouse kidney using Rat Anti-mouse Uromodulin Monoclonal Antibody (Product # MA5-24374) at 10 µg/mL overnight at 4 °C. Tissue was stained using a 557-conjugated Anti-Rat IgG Secondary Antibody (red) and counterstained with DAPI (blue). Specific staining was localized to convoluted tubule epithelial cells.
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.jpg?time=20250104?time=20250104 "Uromodulin Antibody (MA5-24374) in IHC (F)")
Product Details
MA5-24374
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Published species
Mouse
Host/Isotype
Rat
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
774056
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse Uromodulin Ser24-Ala618
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Purification
Protein A/G
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2606307
Product Specific Information
Reconstitute in sterile PBS to a final concentration of 0.5 mg/mL.
Target Information
This gene encodes uromodulin, the most abundant protein in normal urine. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of uromodulin in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Tamm-Horsfall urinary glycoprotein; THP; Uromodulin; uromucoid; uromucoid uromucoid
Gene Aliases: THP; Umod; Urehd1; urehr4
UniProt ID: (Mouse) Q91X17
Entrez Gene ID: (Mouse) 22242
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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