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Uteroglobin Polyclonal Antibody

Uteroglobin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Uteroglobin Antibody (10490-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded mouse lung tissue slide using 10490-1-AP ( Uteroglobin Antibody) at dilution of 1:200 (under 40x lens).

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Product Details

10490-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

View 2 publications 2 publications

Immunohistochemistry (IHC)

View 7 publications 7 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 4 publications 4 publications

Flow Cytometry (Flow)

Assay-dependent

View 2 publications 2 publications

Immunoprecipitation (IP)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Bovine, Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Uteroglobin Fusion Protein Ag0758 (1-91 aa encoded by BC004481)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.25 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MKLAVTLTL VTLALCCSSA SAEICPSFQR VIETLLMDTP SSYEAAMELF SPDQDMREAG AQLKKLVDTL PQKPRESIIK LMEKIAQSSL CN (1-91 aa encoded by BC004481)

Target Information

Uteroglobin, which is a member of the Secretoglobin superfamily and is also known as Clara cell phospholipid-binding protein, is a multifunctional protein that can exert anti-inflammatory and anti-tumorigenic effects by binding small hydrophobic molecules such as phospholipids and prostaglandins. The small, non-glycosylated protein named for its high levels of expression in pre-implantation embryos, where it exhibits growth stimulatory effects, is produced and secreted by the non-ciliated, non-mucous Clara cells predominant in the epithelial surfaces of pulmonary airways, as well as other non-ciliated epithelia. Members of the Secretoglobin superfamily demonstrate a high level of structural conservation and are characterized as small, secretory homo- or heterodimers. In addition to sequestering pro-inflammatory mediators and carcinogens, Uteroglobin has been implicated in the inhibition of cell migration and invasion, platelet aggregation, and T cell differentiation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Extracellular vesicle-encapsulated CC16 as novel nanotherapeutics for treatment of acute lung injury.

Molecular therapy : the journal of the American Society of Gene Therapy

Han Y,Zhu Y,Almuntashiri S,Wang X,Somanath PR,Owen CA,Zhang D

Wed May 03 00:00:00 UTC 2023

Extracellular vesicle-encapsulated CC16 as novel nanotherapeutics for treatment of acute lung injury.

Molecular therapy : the journal of the American Society of Gene Therapy

Han Y,Zhu Y,Almuntashiri S,Wang X,Somanath PR,Owen CA,Zhang D

Wed May 03 00:00:00 UTC 2023

Extracellular vesicle-encapsulated CC16 as novel nanotherapeutics for treatment of acute lung injury.

Molecular therapy : the journal of the American Society of Gene Therapy

Han Y,Zhu Y,Almuntashiri S,Wang X,Somanath PR,Owen CA,Zhang D

Wed May 03 00:00:00 UTC 2023

SARS-CoV-2 Omicron variant replication in human bronchus and lung ex vivo.

Nature

Hui KPY,Ho JCW,Cheung MC,Ng KC,Ching RHH,Lai KL,Kam TT,Gu H,Sit KY,Hsin MKY,Au TWK,Poon LLM,Peiris M,Nicholls JM,Chan MCW

Tue Mar 01 00:00:00 UTC 2022

Empagliflozin-Enhanced Antioxidant Defense Attenuates Lipotoxicity and Protects Hepatocytes by Promoting FoxO3a- and Nrf2-Mediated Nuclear Translocation via the CAMKK2/AMPK Pathway.

Antioxidants (Basel, Switzerland)

Wang Y,Ding Y,Sun P,Zhang W,Xin Q,Wang N,Niu Y,Chen Y,Luo J,Lu J,Zhou J,Xu N,Zhang Y,Xie W

Tue Apr 19 00:00:00 UTC 2022

Population-wide gene disruption in the murine lung epithelium via AAV-mediated delivery of CRISPR-Cas9 components.

Molecular therapy. Methods & clinical development

Chen H,Durinck S,Patel H,Foreman O,Mesh K,Eastham J,Caothien R,Newman RJ,Roose-Girma M,Darmanis S,Warming S,Lattanzi A,Liang Y,Haley B

Thu Dec 08 00:00:00 UTC 2022

A human fetal lung cell atlas uncovers proximal-distal gradients of differentiation and key regulators of epithelial fates.

Cell

He P,Lim K,Sun D,Pett JP,Jeng Q,Polanski K,Dong Z,Bolt L,Richardson L,Mamanova L,Dabrowska M,Wilbrey-Clark A,Madissoon E,Tuong ZK,Dann E,Suo C,Goh I,Yoshida M,Nikolić MZ,Janes SM,He X,Barker RA,Teichmann SA,Marioni JC,Meyer KB,Rawlins EL

Thu Dec 08 00:00:00 UTC 2022

A SCID mouse-human lung xenograft model of SARS-CoV-2 infection.

Theranostics

Fu W,Wang W,Yuan L,Lin Y,Huang X,Chen R,Cai M,Liu C,Chen L,Zhou M,Wu K,Zhao H,Pan D,Ma J,Hong J,Zhai B,Zhang Y,Kong Z,Wang Y,Chen Y,Yuan Q,Zhu H,Cheng T,Guan Y,Xia N

Mon May 24 00:00:00 UTC 2021

Isolation, expansion, differentiation, and histological processing of human nasal epithelial cells.

STAR protocols

Manna V,Caradonna S

Fri Dec 17 00:00:00 UTC 2021

Overexpression of the SARS-CoV-2 receptor ACE2 is induced by cigarette smoke in bronchial and alveolar epithelia.

The Journal of pathology

Liu A,Zhang X,Li R,Zheng M,Yang S,Dai L,Wu A,Hu C,Huang Y,Xie M,Chen Q

Fri Jan 01 00:00:00 UTC 2021

Tropism, replication competence, and innate immune responses of the coronavirus SARS-CoV-2 in human respiratory tract and conjunctiva: an analysis in ex-vivo and in-vitro cultures.

The Lancet. Respiratory medicine

Hui KPY,Cheung MC,Perera RAPM,Ng KC,Bui CHT,Ho JCW,Ng MMT,Kuok DIT,Shih KC,Tsao SW,Poon LLM,Peiris M,Nicholls JM,Chan MCW

Wed Jul 01 00:00:00 UTC 2020

Spred2-deficiency enhances the proliferation of lung epithelial cells and alleviates pulmonary fibrosis induced by bleomycin.

Scientific reports

Kawara A,Mizuta R,Fujisawa M,Ito T,Li C,Nakamura K,Sun C,Kuwabara M,Kitabatake M,Yoshimura T,Matsukawa A

Mon Oct 05 00:00:00 UTC 2020

Tropism of influenza B viruses in human respiratory tract explants and airway organoids.

The European respiratory journal

Bui CHT,Chan RWY,Ng MMT,Cheung MC,Ng KC,Chan MPK,Chan LLY,Fong JHM,Nicholls JM,Peiris JSM,Chan MCW

Thu Aug 01 00:00:00 UTC 2019

Structural Development, Cellular Differentiation and Proliferation of the Respiratory Epithelium in the Bovine Fetal Lung.

Journal of comparative pathology

Drozdowska J,Cousens C,Finlayson J,Collie D,Dagleish MP

Fri Jan 01 00:00:00 UTC 2016

Structural Development, Cellular Differentiation and Proliferation of the Respiratory Epithelium in the Bovine Fetal Lung.

Journal of comparative pathology

Drozdowska J,Cousens C,Finlayson J,Collie D,Dagleish MP

Fri Jan 01 00:00:00 UTC 2016

Lung adenocarcinoma originates from retrovirus infection of proliferating type 2 pneumocytes during pulmonary post-natal development or tissue repair.

PLoS pathogens

Murgia C,Caporale M,Ceesay O,Di Francesco G,Ferri N,Varasano V,de las Heras M,Palmarini M

Tue Mar 01 00:00:00 UTC 2011

Lung adenocarcinoma originates from retrovirus infection of proliferating type 2 pneumocytes during pulmonary post-natal development or tissue repair.

PLoS pathogens

Murgia C,Caporale M,Ceesay O,Di Francesco G,Ferri N,Varasano V,de las Heras M,Palmarini M

Tue Mar 01 00:00:00 UTC 2011

Identification of mesenchymal stromal cells in human lung parenchyma capable of differentiating into aquaporin 5-expressing cells.

Laboratory investigation; a journal of technical methods and pathology

Karoubi G,Cortes-Dericks L,Breyer I,Schmid RA,Dutly AE

Thu Oct 01 00:00:00 UTC 2009

Identification of mesenchymal stromal cells in human lung parenchyma capable of differentiating into aquaporin 5-expressing cells.

Laboratory investigation; a journal of technical methods and pathology

Karoubi G,Cortes-Dericks L,Breyer I,Schmid RA,Dutly AE

Thu Oct 01 00:00:00 UTC 2009

Bioinformatics

Protein Aliases: Blastokinin; CC10; CCPBP; clara cell 17 kDa protein; clara cell phospholipid-binding protein; clara cell secretory protein; clara cells 10 kDa secretory protein; Club cell 17 kDa protein; Club cell phospholipid-binding protein; Club cells 10 kDa secretory protein; PCB-binding protein; Secretoglobin family 1A member 1; secretoglobin, family 1A, member 1 (uteroglobin); UP-1; Urinary protein 1; urine protein 1; Uteroglobin

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Gene Aliases: CC10; CC16; CCPBP; CCSP; PCB-BP; SCGB1A1; UG; UGB; UP-1; UP1; Utg

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UniProt ID: (Human) P11684, (Mouse) Q06318

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Entrez Gene ID: (Human) 7356, (Mouse) 22287

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Function(s)

protein binding phospholipase A2 inhibitor activity polychlorinated biphenyl binding

Process(es)

negative regulation of transcription from RNA polymerase II promoter signal transduction negative regulation of interferon-gamma production negative regulation of interleukin-13 production negative regulation of interleukin-4 production negative regulation of interleukin-5 production response to cytokine negative regulation of T cell proliferation regulation of mRNA stability regulation of inflammatory response female pregnancy embryo implantation response to xenobiotic stimulus response to ozone response to lipopolysaccharide response to silicon dioxide response to drug negative regulation of catalytic activity response to glucocorticoid response to fibroblast growth factor

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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Uteroglobin Polyclonal Antibody

Uteroglobin Antibody (10490-1-AP) in IHC (P)

Product Details

10490-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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