Proteintech

VAMP3/Cellubrevin Polyclonal Antibody

VAMP3/Cellubrevin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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VAMP3/Cellubrevin Antibody (10702-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human kidney tissue slide using 10702-1-AP (VAMP3/Cellubrevin antibody at dilution of 1:50 (under 40x lens).

VAMP3/Cellubrevin Antibody in Western Blot (WB)

VAMP3/Cellubrevin Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

10702-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 10 publications 10 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 6 publications 6 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

VAMP3/Cellubrevin Fusion Protein Ag1156 (1-99 aa encoded by BC005941)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.35 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MSTGPTAAT GSNRRLQQTQ NQVDEVVDIM RVNVDKVLER DQKLSELDDR ADALQAGASQ FETSAAKLKR KYWWKNCEMW AIGITVLVIF IIIIIVWVVS (1-99 aa encoded by BC005941 )

Target Information

Synaptobrevins/VAMPs, syntaxins, and the 25-kDa synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Because of its high homology to other known VAMPs, its broad tissue distribution, and its subcellular localization, the protein encoded by this gene was shown to be the human equivalent of the rodent cellubrevin. In platelets the protein resides on a compartment that is not mobilized to the plasma membrane on calcium or thrombin stimulation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Early Endosomes Act as Local Exocytosis Hubs to Repair Endothelial Membrane Damage.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Raj N,Greune L,Kahms M,Mildner K,Franzkoch R,Psathaki OE,Zobel T,Zeuschner D,Klingauf J,Gerke V

Mon May 01 00:00:00 UTC 2023

Early Endosomes Act as Local Exocytosis Hubs to Repair Endothelial Membrane Damage.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Raj N,Greune L,Kahms M,Mildner K,Franzkoch R,Psathaki OE,Zobel T,Zeuschner D,Klingauf J,Gerke V

Mon May 01 00:00:00 UTC 2023

Astrocytic N-Methyl-D-Aspartate Receptors Protect the Hippocampal Neurons Against Amyloid-β142-Induced Synaptotoxicity by Regulating Nerve Growth Factor.

Journal of Alzheimer's disease : JAD

Song Y,Du Z,Chen X,Zhang W,Zhang G,Li H,Chang L,Wu Y

Tue Feb 15 00:00:00 UTC 2022

Astrocytic N-Methyl-D-Aspartate Receptors Protect the Hippocampal Neurons Against Amyloid-β142-Induced Synaptotoxicity by Regulating Nerve Growth Factor.

Journal of Alzheimer's disease : JAD

Song Y,Du Z,Chen X,Zhang W,Zhang G,Li H,Chang L,Wu Y

Tue Feb 15 00:00:00 UTC 2022

Multifunctional regulation of VAMP3 in exocytic and endocytic pathways of RBL-2H3 cells.

Frontiers in immunology

Mishima S,Sakamoto M,Kioka H,Nagata Y,Suzuki R

Tue Aug 23 00:00:00 UTC 2022

Recruitment of DNA to tumor-derived microvesicles.

Cell reports

Clancy JW,Sheehan CS,Boomgarden AC,D'Souza-Schorey C

Tue Mar 01 00:00:00 UTC 2022

Knockdown of astrocytic Grin2a aggravates β-amyloid-induced memory and cognitive deficits through regulating nerve growth factor.

Aging cell

Du Z,Song Y,Chen X,Zhang W,Zhang G,Li H,Chang L,Wu Y

Sun Aug 01 00:00:00 UTC 2021

Knockdown of astrocytic Grin2a aggravates β-amyloid-induced memory and cognitive deficits through regulating nerve growth factor.

Aging cell

Du Z,Song Y,Chen X,Zhang W,Zhang G,Li H,Chang L,Wu Y

Sun Aug 01 00:00:00 UTC 2021

VAMP3 and SNAP23 as Potential Targets for Preventing the Disturbed Flow-Accelerated Thrombus Formation.

Frontiers in cell and developmental biology

Zhu JJ,Jiang ZT,Liu C,Xi YF,Wang J,Yang FF,Yao WJ,Pang W,Han LL,Zhang YH,Sun AQ,Zhou J

Tue Nov 24 00:00:00 UTC 2020

Exogenous H₂S Induces Hrd1 S-sulfhydration and Prevents CD36 Translocation via VAMP3 Ubiquitylation in Diabetic Hearts.

Aging and disease

Yu M,Du H,Wang B,Chen J,Lu F,Peng S,Sun Y,Liu N,Sun X,Shiyun D,Zhao Y,Wang Y,Zhao D,Lu F,Zhang W

Wed Apr 01 00:00:00 UTC 2020

Exogenous H₂S Induces Hrd1 S-sulfhydration and Prevents CD36 Translocation via VAMP3 Ubiquitylation in Diabetic Hearts.

Aging and disease

Yu M,Du H,Wang B,Chen J,Lu F,Peng S,Sun Y,Liu N,Sun X,Shiyun D,Zhao Y,Wang Y,Zhao D,Lu F,Zhang W

Wed Apr 01 00:00:00 UTC 2020

KRAS regulation by small non-coding RNAs and SNARE proteins.

Nature communications

Che Y,Siprashvili Z,Kovalski JR,Jiang T,Wozniak G,Elcavage L,Khavari PA

Mon Nov 11 00:00:00 UTC 2019

KRAS regulation by small non-coding RNAs and SNARE proteins.

Nature communications

Che Y,Siprashvili Z,Kovalski JR,Jiang T,Wozniak G,Elcavage L,Khavari PA

Mon Nov 11 00:00:00 UTC 2019

Systematic In-Depth Proteomic Analysis of Mitochondria-Associated Endoplasmic Reticulum Membranes in Mouse and Human Testes.

Proteomics

Wang X,Wen Y,Dong J,Cao C,Yuan S

Sun Jul 01 00:00:00 UTC 2018

Systematic In-Depth Proteomic Analysis of Mitochondria-Associated Endoplasmic Reticulum Membranes in Mouse and Human Testes.

Proteomics

Wang X,Wen Y,Dong J,Cao C,Yuan S

Sun Jul 01 00:00:00 UTC 2018

Systematic In-Depth Proteomic Analysis of Mitochondria-Associated Endoplasmic Reticulum Membranes in Mouse and Human Testes.

Proteomics

Wang X,Wen Y,Dong J,Cao C,Yuan S

Sun Jul 01 00:00:00 UTC 2018

A novel liver metastasis-correlated protein of pancreatic neuroendocrine neoplasm (PanNEN) discovered by proteomic analysis.

Oncotarget

Shimura M,Mizuma M,Takadate T,Katoh Y,Suzuki T,Iseki M,Hata T,Aoki S,Suzuki Y,Sakata N,Ohtsuka H,Hayashi H,Morikawa T,Nakagawa K,Motoi F,Naitoh T,Igarashi K,Sasano H,Unno M

Fri May 11 00:00:00 UTC 2018

A novel liver metastasis-correlated protein of pancreatic neuroendocrine neoplasm (PanNEN) discovered by proteomic analysis.

Oncotarget

Shimura M,Mizuma M,Takadate T,Katoh Y,Suzuki T,Iseki M,Hata T,Aoki S,Suzuki Y,Sakata N,Ohtsuka H,Hayashi H,Morikawa T,Nakagawa K,Motoi F,Naitoh T,Igarashi K,Sasano H,Unno M

Fri May 11 00:00:00 UTC 2018

Glia Maturation Factor-γ Regulates Monocyte Migration through Modulation of β1-Integrin.

The Journal of biological chemistry

Aerbajinai W,Liu L,Zhu J,Kumkhaek C,Chin K,Rodgers GP

Fri Apr 15 00:00:00 UTC 2016

Glia Maturation Factor-γ Regulates Monocyte Migration through Modulation of β1-Integrin.

The Journal of biological chemistry

Aerbajinai W,Liu L,Zhu J,Kumkhaek C,Chin K,Rodgers GP

Fri Apr 15 00:00:00 UTC 2016

C-reactive protein promotes atherosclerosis by increasing LDL transcytosis across endothelial cells.

British journal of pharmacology

Bian F,Yang X,Zhou F,Wu PH,Xing S,Xu G,Li W,Chi J,Ouyang C,Zhang Y,Xiong B,Li Y,Zheng T,Wu D,Chen X,Jin S

Thu May 01 00:00:00 UTC 2014

C-reactive protein promotes atherosclerosis by increasing LDL transcytosis across endothelial cells.

British journal of pharmacology

Bian F,Yang X,Zhou F,Wu PH,Xing S,Xu G,Li W,Chi J,Ouyang C,Zhang Y,Xiong B,Li Y,Zheng T,Wu D,Chen X,Jin S

Thu May 01 00:00:00 UTC 2014

Bioinformatics

Protein Aliases: CEB; Cellubrevin; Synaptobrevin-3; vamp; VAMP-3; Vesicle-associated membrane protein 3

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Gene Aliases: CEB; D130027G05Rik; SYB3; VAMP-3; VAMP3

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UniProt ID: (Human) Q15836, (Mouse) P63024, (Rat) P63025

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Entrez Gene ID: (Human) 9341, (Mouse) 22319, (Rat) 29528

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Function(s)

SNARE binding SNAP receptor activity protein binding syntaxin-1 binding

Process(es)

positive regulation of receptor recycling protein complex assembly transport vesicle fusion protein transport vesicle-mediated transport calcium ion regulated exocytosis substrate adhesion-dependent cell spreading SNARE complex assembly retrograde transport, endosome to Golgi Golgi to plasma membrane protein transport negative regulation of secretion by cell exocytosis vesicle docking involved in exocytosis positive regulation of immunoglobulin secretion membrane fusion mucus secretion regulation of histamine secretion by mast cell neurotransmitter secretion

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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VAMP3/Cellubrevin Polyclonal Antibody

VAMP3/Cellubrevin Antibody (10702-1-AP) in IHC (P)

Product Details

10702-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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