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Product Details
12730-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
VASH1 Fusion Protein Ag3435 (1-204 aa encoded by BC009031)
Conjugate
Form
Liquid
Concentration
0.29 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
12730-1-AP detects 41 kDa form secreted protein and 36 kDa form protein accumulated within the cells or pericellular milieu in SDS-PAGE.
Immunogen sequence: MPGGKKVAG GGSSGATPTS AAATAPSGVR RLETSEGTSA QRDEEPEEEG EEDLRDGGVP FFVNRGGLPV DEATWERMWK HVAKIHPDGE KVAQRIRGAT DLPKIPIPSV PTFQPSTPVP ERLEAVQRYI RELQYNHTGT QFFEIKKSRP LTGLMDLAKE MTKEALPIKC LEAVILGMYP SSPEGEGSGL LWASASCSES EGGVG (1-204 aa encoded by BC009031)
Target Information
VASH1 is a protein that possesses actin binding activity and metallocarboxypeptidase activity. It is involved in several processes including negative regulation of angiogenesis, negative regulation of blood vessel endothelial cell migration, and proteolysis. VASH1 acts upstream of or within processes such as negative regulation of endothelial cell migration, negative regulation of endothelial cell proliferation, and negative regulation of lymphangiogenesis. It is located in the apical part of the cell, endoplasmic reticulum, and extracellular space. VASH1 is implicated in liver cirrhosis and portal hypertension, and is a biomarker of liver cirrhosis. Diseases associated with VASH1 include Portal Hypertension and Myasthenic Syndrome, Congenital, 14.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: TTCP 1; Tubulin carboxypeptidase 1; Tubulinyl-Tyr carboxypeptidase 1; Tyrosine carboxypeptidase 1; Vasohibin-1
Gene Aliases: KIAA1036; VASH; VASH1
UniProt ID: (Human) Q7L8A9
Entrez Gene ID: (Human) 22846
angiogenesis
negative regulation of endothelial cell proliferation
cell cycle arrest
response to wounding
negative regulation of endothelial cell migration
negative regulation of angiogenesis
negative regulation of blood vessel endothelial cell migration
negative regulation of lymphangiogenesis
regulation of cellular senescence
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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