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Invitrogen
VAV3 Recombinant Rabbit Monoclonal Antibody (9A10D8)
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VAV3 Antibody (MA5-42927) in IHC (P)
Immunohistochemistry analysis of VAV3 in paraffin-embedded human esophageal cancer. Samples were incubated with VAV3 Monoclonal antibody (Product # MA5-42927) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
Product Details
MA5-42927
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
9A10D8
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 700-800 of human VAV3 (Q9UKW4).
Conjugate
Form
Liquid
Concentration
0.66 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2912068
Product Specific Information
Positive test controls include: Jurkat, Mouse brain.
Immunogen sequence: TKESGEYAIS IKYNNEAKHI KILTRDGFFH IAENRKFKSL MELVEYYKHH SLKEGFRTLD TTLQFPYKEP EHSAGQRGNR AGNSLLSPKV LGIAIARYDF C
Target Information
This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ40431; Guanine nucleotide exchange factor VAV3; vav 3 guanine nucleotide exchange factor; vav 3 oncogene; VAV-3
Gene Aliases: A530094I06Rik; AA986410; Idd18.1; VAV3
UniProt ID: (Human) Q9UKW4, (Mouse) Q9R0C8
Entrez Gene ID: (Human) 10451, (Mouse) 57257
angiogenesis
vesicle fusion
cellular response to DNA damage stimulus
integrin-mediated signaling pathway
small GTPase mediated signal transduction
regulation of cell size
positive regulation of signal transduction
lamellipodium assembly
platelet activation
neutrophil chemotaxis
positive regulation of B cell proliferation
regulation of Rho protein signal transduction
Fc-epsilon receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
response to drug
positive regulation of apoptotic process
regulation of GTPase activity
positive regulation of GTPase activity
positive regulation of phosphatidylinositol 3-kinase activity
positive regulation of cell adhesion
vascular endothelial growth factor receptor signaling pathway
ephrin receptor signaling pathway
B cell receptor signaling pathway
regulation of small GTPase mediated signal transduction
cell migration
cell projection assembly
intracellular signal transduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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