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Product Details
PA5-85405
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human VDAC1. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.35 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2792547
Product Specific Information
Keep as concentrated solution.
Predicted reactivity: Mouse (97%), Rat (97%), Xenopus laevis (85%), Pig (98%), Rabbit (99%), Chicken (93%), Sheep (99%), Rhesus Monkey (98%), Bovine (99%).
Positive Control: A431, H1299, HeLa, HepG2, F05, F32, F39, F90.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Voltage-dependent anion channel (VDAC) proteins are abundant, pore-forming proteins belonging to the eukaryotic mitochondrial porins. It was discovered in the mitochondrial outer membrane. It also is expressed in the plasma membrane. At least three different VDAC genes have been identified in vertebrates. VDAC proteins are known to play an essential role in cellular metabolism and in the early stages of apoptosis. For example, VDAC constitutes a major pathway by which metabolites such as ADP/ATP, succinate and citrate are exchanged between the cytosol and mitochondria. And VDAC1 in the plasma membrane establishes a novel level of apoptosis regulation putatively via its redox activity.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hVDAC1; MGC111064; Mitochondrial Porin; mVDAC1; mVDAC5; Non-selective voltage-gated ion channel VDAC1; Outer mitochondrial membrane protein porin 1; Plasmalemmal porin; Porin 31HL; Porin 31HM; PORIN-31-HL; rVDAC1; VD; VDAC-1; VDAC-5; Voltage-dependent anion-selective channel protein 1; Voltage-dependent anion-selective channel protein 5
Gene Aliases: AL033343; PORIN; VDAC; VDAC-1; VDAC1; Vdac5
UniProt ID: (Human) P21796, (Mouse) Q60932, (Rat) Q9Z2L0
Entrez Gene ID: (Human) 7416, (Mouse) 22333, (Rat) 83529
behavioral fear response
transport
ion transport
anion transport
mitochondrial calcium ion transport
apoptotic process
chemical synaptic transmission
neuron-neuron synaptic transmission
learning
regulation of anion transport
transmembrane transport
anion transmembrane transport
regulation of anion transmembrane transport
epithelial cell differentiation
ion transmembrane transport
regulation of ion transmembrane transport
viral process
macroautophagy
regulation of mitophagy
negative regulation of reactive oxygen species metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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