Invitrogen

VEGF Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-143409

Applications
Tested Dilution
Publications

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:100-1:500
-
Product Specifications

Species Reactivity

Zebrafish

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein encompassing a sequence within the center region of zebrafish Vegfaa. The exact sequence is proprietary.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 20% glycerol

Contains

0.01% thimerosal

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2938404

Product Specific Information

Store as concentrated solution.

Centrifuge briefly prior to opening vial.

Target Information

VEGF (vascular endothelial growth factor) which is a 45 kDa homodimeric, disulfide-linked glycoprotein involved in angiogenesis which promotes tumor progression and metastasis. VEGF has a variety of effects on vascular endothelium, including the ability to promote endothelial cell viability, mitogenesis, chemotaxis, and vascular permeability. The VEGF family currently includes VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E, and PIGF. VEGF and its receptor system have been shown to be the fundamental regulators in the cell signaling of angiogenesis. Most tumors have the absolute requirement of angiogenesis, and VEGF has been described as the most potent angiogenic cytokine linked to this process. To date 5 different isoforms of VEGF have been described. These isoforms are generated as the result of alternative splicing from a single VEGF gene. These various isoforms have been shown to bind to two tyrosine-kinase receptors flt-1 (VEGFR-1) and flk-1/KDR (VEGFR-2), which have been found to be expressed almost exclusively on endothelial cells. VEGF and its high-affinity binding receptors, the tyrosine kinases FLK1 and FLT1, are thought to be important for the development of embryonic vasculature. Studies have shown that an alternately spliced form of FLT1 produces a soluble protein, termed sFLT1, which binds vascular endothelial growth factor with high affinity, playing an inhibitory role in angiogenesis. Elevated levels of VEGF is linked to POEMS syndrome (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammopathy, Skin changes) also known as Crow-Fukase syndrome which affects multiple organs in the body.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: etID309976.16; human VEGF121 homolog; MGC70609; RP1-261G23.1; VAS; vascular endothelial growth factor A; Vascular endothelial growth factor A-A; Vasculotropin; vegf-a; VEGF-A-A; VEGF1; VEGFMGC70609; VPF ant

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Gene Aliases: vegf; vegfa; vegfaa; wu:fj82c06

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UniProt ID: (Zebrafish) O73682

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Entrez Gene ID: (Zebrafish) 30682

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Function(s)
vascular endothelial growth factor receptor binding protein binding growth factor activity heparin binding chemoattractant activity vascular endothelial growth factor receptor 1 binding
Process(es)
angiogenesis blood vessel development patterning of blood vessels vasculogenesis response to hypoxia positive regulation of protein phosphorylation positive regulation of endothelial cell proliferation vasculature development sprouting angiogenesis blood vessel endothelial cell proliferation involved in sprouting angiogenesis endocardial progenitor cell migration to the midline involved in heart field formation activation of phospholipase C activity multicellular organism development regulation of heart contraction motor neuron axon guidance response to glucose hemopoiesis cell differentiation thyroid gland development positive regulation of protein complex assembly regulation of angioblast cell migration involved in selective angioblast sprouting angioblast cell migration from lateral mesoderm to midline vascular endothelial growth factor signaling pathway protein kinase B signaling positive regulation of angiogenesis vascular endothelial growth factor receptor signaling pathway pronephros development artery morphogenesis positive regulation of peptidyl-tyrosine phosphorylation induction of positive chemotaxis positive regulation of cell division positive regulation of focal adhesion assembly positive regulation of mast cell chemotaxis regulation of vasculature development
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