Invitrogen

VEGF Receptor 1/2 Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA1-16612

Applications
Tested Dilution
Publications

Western Blot (WB)

1:100-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:250-1:500
-

Immunocytochemistry (ICC/IF)

1:500
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide made to an internal region of the murine VEGFR1 (residues 800-900): 87% identity to the VEGFR-2 protein
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

TBS

Contains

0.05% sodium azide

Storage conditions

4°C, do not freeze

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_568765

Product Specific Information

The target sequence has 100% sequence homology with mouse and rat.

Target Information

Receptors for VEGF, VEGFB and PGF have a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. VEGF and its high-affinity binding receptors, the tyrosine kinases FLK1 and FLT1, are thought to be important for the development of embryonic vasculature. It has been shown that an alternately spliced form of FLT1 produces a soluble protein, termed sFLT1, which binds vascular endothelial growth factor with high affinity, playing an inhibitory role in angiogenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CD309; Fetal liver kinase 1; fetal liver kinase-1; FLK-1; FLT; FLT-1; Fms-like tyrosine kinase 1; fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor); KDR; Kinase insert domain receptor; kinase insert domain receptor (a type III receptor tyrosine kinase); Protein-tyrosine kinase receptor flk-1; soluble VEGFR 1; soluble VEGFR2; sVEGFR 1; tyrosine kinase growth factor receptor; Tyrosine-protein kinase FRT; Tyrosine-protein kinase receptor FLT; Vascular endothelial growth factor receptor 1; Vascular endothelial growth factor receptor 2; Vascular permeability factor receptor; VEGF R1; VEGFR 1; VEGFR-1; VEGFR-2

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Gene Aliases: CD309; FLK1; FLT; FLT-1; FLT1; FRT; KDR; VEGFR; VEGFR-1; VEGFR1; VEGFR2

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UniProt ID: (Human) P17948, (Human) P35968

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Entrez Gene ID: (Human) 2321, (Human) 3791

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Function(s)
transmembrane receptor protein tyrosine kinase activity vascular endothelial growth factor-activated receptor activity protein binding ATP binding growth factor binding VEGF-A-activated receptor activity VEGF-B-activated receptor activity placental growth factor-activated receptor activity protein tyrosine kinase activity receptor signaling protein tyrosine kinase activity integrin binding Hsp90 protein binding
Process(es)
activation of MAPKK activity angiogenesis response to hypoxia monocyte chemotaxis regulation of smooth muscle contraction transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of cell proliferation positive regulation of phospholipase C activity positive regulation of phosphatidylinositol 3-kinase signaling cell migration peptidyl-tyrosine phosphorylation cell differentiation positive regulation of cell migration intracellular receptor signaling pathway positive regulation of vascular endothelial growth factor receptor signaling pathway cellular response to vascular endothelial growth factor stimulus vascular endothelial growth factor receptor-1 signaling pathway vascular endothelial growth factor signaling pathway positive regulation of MAP kinase activity positive regulation of MAPK cascade positive regulation of phosphatidylinositol 3-kinase activity positive regulation of angiogenesis protein autophosphorylation vascular endothelial growth factor receptor signaling pathway blood vessel morphogenesis embryonic morphogenesis positive regulation of smooth muscle cell proliferation vasculogenesis positive regulation of protein phosphorylation positive regulation of endothelial cell proliferation cell migration involved in sprouting angiogenesis endothelium development regulation of cell shape positive regulation of endothelial cell migration viral process positive regulation of macroautophagy signal transduction by protein phosphorylation extracellular matrix organization embryonic hemopoiesis calcium-mediated signaling using intracellular calcium source positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway peptidyl-tyrosine autophosphorylation negative regulation of apoptotic process positive regulation of positive chemotaxis positive regulation of nitric-oxide synthase biosynthetic process positive regulation of focal adhesion assembly positive regulation of mitochondrial depolarization positive regulation of ERK1 and ERK2 cascade positive regulation of mitochondrial fission negative regulation of endothelial cell apoptotic process positive regulation of vasculogenesis
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