Proteintech

VEGFR-1/FLT-1 Polyclonal Antibody

VEGFR-1/FLT-1 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 9

VEGFR-1/FLT-1 Antibody (13687-1-AP) in ICC/IF

Immunofluorescent analysis of HeLa cells using 13687-1-AP (VEGFR-1/FLT-1 antibody) at dilution of 1:25 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

VEGFR-1/FLT-1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

VEGFR-1/FLT-1 Antibody in Western Blot (WB)

VEGFR-1/FLT-1 Antibody in Flow Cytometry (Flow)

VEGFR-1/FLT-1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

13687-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 24 publications 24 publications

Immunohistochemistry (IHC)

View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:2,000

Immunocytochemistry (ICC/IF)

1:10-1:100

View 1 publication 1 publication

Flow Cytometry (Flow)

0.2 µg/1x10^6 cells

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Deer, Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

VEGFR-1/FLT-1 Fusion Protein Ag4558 (21-300 aa encoded by BC039007)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.26 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: TGSSSGSKL KDPELSLKGT QHIMQAGQTL HLQCRGEAAH KWSLPEMVSK ESERLSITKS ACGRNGKQFC STLTLNTAQA NHTGFYSCKY LAVPTSKKKE TESAIYIFIS DTGRPFVEMY SEIPEIIHMT EGRELVIPCR VTSPNITVTL KKFPLDTLIP DGKRIIWDSR KGFIISNATY KEIGLLTCEA TVNGHLYKTN YLTHRQTNTI IDVQISTPRP VKLLRGHTLV LNCTATTPLN TRVQMTWSYP DEKNKRASVR RRIDQSNSHA NIFYSVLTID K (21-300 aa encoded by BC039007)

Target Information

FLT1 (VEGFR1) is a receptor tyrosine kinase which plays a critical role in angiogenesis. Active angiogenesis has been found to play important role in many pathological and physiological processes, such as tumor progression, diabetic retinopathy, rheumatoid arthritis and wound healing. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity; may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Delivery of miR-130a-3p Through Adipose-Derived Stem Cell-Secreted EVs Protects Against Diabetic Peripheral Neuropathy via DNMT1/NRF2/HIF1α/ACTA1 Axis.

Molecular neurobiology

Chen J,Li G,Liu X,Chen K,Wang Y,Qin J,Yang F

Sat Jul 01 00:00:00 UTC 2023

Optimizing human endometrial mesenchymal stem cells for maximal induction of angiogenesis.

Molecular and cellular biochemistry

Zhang J,Song H,Fan X,He S,Yin W,Peng Z,Zhai X,Yang K,Gong H,Wang Z,Ping Y,Zhang S,Li RK,Xie J

Thu Jun 01 00:00:00 UTC 2023

NRP1 contributes to stemness and potentiates radioresistance via WTAP-mediated m6A methylation of Bcl-2 mRNA in breast cancer.

Apoptosis : an international journal on programmed cell death

Wang Y,Zhang L,Sun XL,Lu YC,Chen S,Pei DS,Zhang LS

Wed Feb 01 00:00:00 UTC 2023

NRP1 contributes to stemness and potentiates radioresistance via WTAP-mediated m6A methylation of Bcl-2 mRNA in breast cancer.

Apoptosis : an international journal on programmed cell death

Wang Y,Zhang L,Sun XL,Lu YC,Chen S,Pei DS,Zhang LS

Wed Feb 01 00:00:00 UTC 2023

BEST1 Positive Monocytes in Circulation: Visualize Intratumoral Crosstalk between Cancer Cells and Monocytes.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Zhang L,Wang Y,Yuan W,An C,Tan Q,Ma J

Thu Jun 01 00:00:00 UTC 2023

P53 Deficiency Accelerate Esophageal Epithelium Intestinal Metaplasia Malignancy.

Biomedicines

Qiu Q,Guo G,Guo X,Hu X,Yu T,Liu G,Zhang H,Chen Y,She J

Mon Mar 13 00:00:00 UTC 2023

Impact of repeated intravenous infusions of umbilical cord-derived versus bone marrow-derived mesenchymal stem cells on angiogenesis in a pregnant experimentally induced deep venous thrombosis rat model.

In vitro cellular & developmental biology. Animal

Cheng X,Wang W,Du R,Zhang M,Xie Y,Sun W,Ji J,Sun B,Zhang Y

Thu Dec 01 00:00:00 UTC 2022

Bevacizumab is an Efficient Therapeutic Approach with Low Side Effects in Patient-Derived Xenografts of Adenoid Cystic Carcinoma of the Lacrimal Gland.

Cancer management and research

Zhang J,Yan X,Liu R,Wu S,Liu Q,Li J,Ma J

Wed Mar 16 00:00:00 UTC 2022

Honeymoon Period in Newborn Rats With CDH Is Associated With Changes in the VEGF Signaling Pathway.

Frontiers in pediatrics

Miura da Costa K,Fabro AT,Becari C,Figueira RL,Schmidt AF,Ruano R,Sbragia L

Tue Aug 13 00:00:00 UTC 2024

Anti-anemia drug FG4592 retards the AKI-to-CKD transition by improving vascular regeneration and antioxidative capability.

Clinical science (London, England : 1979)

Wu M,Chen W,Miao M,Jin Q,Zhang S,Bai M,Fan J,Zhang Y,Zhang A,Jia Z,Huang S

Fri Jul 30 00:00:00 UTC 2021

IL-1β Promotes Vasculogenic Mimicry of Breast Cancer Cells Through p38/MAPK and PI3K/Akt Signaling Pathways.

Frontiers in oncology

Nisar MA,Zheng Q,Saleem MZ,Ahmmed B,Ramzan MN,Ud Din SR,Tahir N,Liu S,Yan Q

Tue Jun 01 00:00:00 UTC 2021

IL-1β Promotes Vasculogenic Mimicry of Breast Cancer Cells Through p38/MAPK and PI3K/Akt Signaling Pathways.

Frontiers in oncology

Nisar MA,Zheng Q,Saleem MZ,Ahmmed B,Ramzan MN,Ud Din SR,Tahir N,Liu S,Yan Q

Tue Jun 01 00:00:00 UTC 2021

IL-1β Promotes Vasculogenic Mimicry of Breast Cancer Cells Through p38/MAPK and PI3K/Akt Signaling Pathways.

Frontiers in oncology

Nisar MA,Zheng Q,Saleem MZ,Ahmmed B,Ramzan MN,Ud Din SR,Tahir N,Liu S,Yan Q

Tue Jun 01 00:00:00 UTC 2021

Effects of S1PR2 antagonist on blood pressure and angiogenesis imbalance in preeclampsia rats.

Molecular medicine reports

Zhang T,Guo D,Zheng W,Dai Q

Tue Jun 01 00:00:00 UTC 2021

Biocompatible Chitin Hydrogel Incorporated with PEDOT Nanoparticles for Peripheral Nerve Repair.

ACS applied materials & interfaces

Huang L,Yang X,Deng L,Ying D,Lu A,Zhang L,Yu A,Duan B

Wed Apr 14 00:00:00 UTC 2021

Human endometrium-derived stem cell improves cardiac function after myocardial ischemic injury by enhancing angiogenesis and myocardial metabolism.

Stem cell research & therapy

Fan X,He S,Song H,Yin W,Zhang J,Peng Z,Yang K,Zhai X,Zhao L,Gong H,Ping Y,Jiao X,Zhang S,Yan C,Wang H,Li RK,Xie J

Thu Jun 10 00:00:00 UTC 2021

Genome-wide translational reprogramming of genes important for myocyte functions in overload-induced heart failure.

Biochimica et biophysica acta. Molecular basis of disease

Guo Q,Zhang Y,Zhang S,Jin J,Pang S,Wu X,Zhang W,Bi X,Zhang Y,Zhang Q,Jiang F

Sun Mar 01 00:00:00 UTC 2020

Decreased ZNF750 promotes angiogenesis in a paracrine manner via activating DANCR/miR-4707-3p/FOXC2 axis in esophageal squamous cell carcinoma.

Cell death & disease

Bi Y,Guo S,Xu X,Kong P,Cui H,Yan T,Ma Y,Cheng Y,Chen Y,Liu X,Zhang L,Cheng C,Xu E,Qian Y,Yang J,Song B,Li H,Wang F,Hu X,Liu X,Niu X,Zhai Y,Liu J,Li Y,Cheng X,Cui Y

Mon Apr 27 00:00:00 UTC 2020

Exosomes from hypoxia-treated human adipose-derived mesenchymal stem cells enhance angiogenesis through VEGF/VEGF-R.

The international journal of biochemistry & cell biology

Han Y,Ren J,Bai Y,Pei X,Han Y

Mon Apr 01 00:00:00 UTC 2019

RhTyrRS (Y341A), a novel human tyrosyl-tRNA synthetase mutant, stimulates thrombopoiesis through activation of the VEGF-R II/NF-κB pathway.

Biochemical pharmacology

Shi Y,Yu J,Zhang Y,Zhao B,Li Y,Ye Y,Yu Q,Yu M,Mo W,Gu J

Fri Nov 01 00:00:00 UTC 2019

PlGF signaling and macrophage repolarization contribute to the anti-neoplastic effect of metformin.

European journal of pharmacology

Ma Q,Gu JT,Wang B,Feng J,Yang L,Kang XW,Duan P,Sun X,Liu PJ,Wang JC

Fri Nov 15 00:00:00 UTC 2019

PlGF signaling and macrophage repolarization contribute to the anti-neoplastic effect of metformin.

European journal of pharmacology

Ma Q,Gu JT,Wang B,Feng J,Yang L,Kang XW,Duan P,Sun X,Liu PJ,Wang JC

Fri Nov 15 00:00:00 UTC 2019

PlGF signaling and macrophage repolarization contribute to the anti-neoplastic effect of metformin.

European journal of pharmacology

Ma Q,Gu JT,Wang B,Feng J,Yang L,Kang XW,Duan P,Sun X,Liu PJ,Wang JC

Fri Nov 15 00:00:00 UTC 2019

PlGF signaling and macrophage repolarization contribute to the anti-neoplastic effect of metformin.

European journal of pharmacology

Ma Q,Gu JT,Wang B,Feng J,Yang L,Kang XW,Duan P,Sun X,Liu PJ,Wang JC

Fri Nov 15 00:00:00 UTC 2019

Exosomal miR-1229 derived from colorectal cancer cells promotes angiogenesis by targeting HIPK2.

International journal of biological macromolecules

Hu HY,Yu CH,Zhang HH,Zhang SZ,Yu WY,Yang Y,Chen Q

Mon Jul 01 00:00:00 UTC 2019

Tumor necrosis factor-α regulates angiogenesis of BeWo cells via synergy of PlGF/VEGFR1 and VEGF-A/VEGFR2 axes.

Placenta

Tanaka K,Watanabe M,Tanigaki S,Iwashita M,Kobayashi Y

Sat Dec 15 00:00:00 UTC 2018

Tumor necrosis factor-α regulates angiogenesis of BeWo cells via synergy of PlGF/VEGFR1 and VEGF-A/VEGFR2 axes.

Placenta

Tanaka K,Watanabe M,Tanigaki S,Iwashita M,Kobayashi Y

Sat Dec 15 00:00:00 UTC 2018

Tumor necrosis factor-α regulates angiogenesis of BeWo cells via synergy of PlGF/VEGFR1 and VEGF-A/VEGFR2 axes.

Placenta

Tanaka K,Watanabe M,Tanigaki S,Iwashita M,Kobayashi Y

Sat Dec 15 00:00:00 UTC 2018

Tumor necrosis factor-α regulates angiogenesis of BeWo cells via synergy of PlGF/VEGFR1 and VEGF-A/VEGFR2 axes.

Placenta

Tanaka K,Watanabe M,Tanigaki S,Iwashita M,Kobayashi Y

Sat Dec 15 00:00:00 UTC 2018

Screening of differentially expressed proteins from syncytiotrophoblast for severe early-onset preeclampsia in women with gestational diabetes mellitus using tandem mass tag quantitative proteomics.

BMC pregnancy and childbirth

Sun X,Qu T,He X,Yang X,Guo N,Mao Y,Xu X,Sun X,Zhang X,Wang W

Wed Nov 07 00:00:00 UTC 2018

Deer thymosin beta 10 functions as a novel factor for angiogenesis and chondrogenesis during antler growth and regeneration.

Stem cell research & therapy

Zhang W,Chu W,Liu Q,Coates D,Shang Y,Li C

Tue Jun 19 00:00:00 UTC 2018

Deer thymosin beta 10 functions as a novel factor for angiogenesis and chondrogenesis during antler growth and regeneration.

Stem cell research & therapy

Zhang W,Chu W,Liu Q,Coates D,Shang Y,Li C

Tue Jun 19 00:00:00 UTC 2018

Vascular endothelial growth factor is neuroprotective against ischemic brain injury by inhibiting scavenger receptor A expression on microglia.

Journal of neurochemistry

Xu Z,Han K,Chen J,Wang C,Dong Y,Yu M,Bai R,Huang C,Hou L

Fri Sep 01 00:00:00 UTC 2017

Vascular endothelial growth factor is neuroprotective against ischemic brain injury by inhibiting scavenger receptor A expression on microglia.

Journal of neurochemistry

Xu Z,Han K,Chen J,Wang C,Dong Y,Yu M,Bai R,Huang C,Hou L

Fri Sep 01 00:00:00 UTC 2017

The effects of 1,4-dimethylpyridine in metastatic prostate cancer in mice.

BMC cancer

Denslow A,Switalska M,Nowak M,Maciejewska M,Chlopicki S,Marcinek A,Gebicki J,Wietrzyk J

Tue Mar 07 00:00:00 UTC 2017

The effects of 1,4-dimethylpyridine in metastatic prostate cancer in mice.

BMC cancer

Denslow A,Switalska M,Nowak M,Maciejewska M,Chlopicki S,Marcinek A,Gebicki J,Wietrzyk J

Tue Mar 07 00:00:00 UTC 2017

The effects of Tao-Hong-Si-Wu on hepatic necroinflammatory activity and fibrosis in a murine model of chronic liver disease.

Journal of ethnopharmacology

Xi S,Shi M,Jiang X,Minuk GY,Cheng Y,Peng Y,Gong Y,Xu Y,Wang X,Yang J,Yue L,Wang Y

Wed Mar 02 00:00:00 UTC 2016

The effects of Tao-Hong-Si-Wu on hepatic necroinflammatory activity and fibrosis in a murine model of chronic liver disease.

Journal of ethnopharmacology

Xi S,Shi M,Jiang X,Minuk GY,Cheng Y,Peng Y,Gong Y,Xu Y,Wang X,Yang J,Yue L,Wang Y

Wed Mar 02 00:00:00 UTC 2016

The Effects of Taoren-Honghua Herb Pair on Pathological Microvessel and Angiogenesis-Associated Signaling Pathway in Mice Model of CCl4-Induced Chronic Liver Disease.

Evidence-based complementary and alternative medicine : eCAM

Xi S,Yue L,Shi M,Peng Y,Xu Y,Wang X,Li Q,Kang Z,Li H,Wang Y

Mon Jun 13 00:00:00 UTC 2016

The Effects of Taoren-Honghua Herb Pair on Pathological Microvessel and Angiogenesis-Associated Signaling Pathway in Mice Model of CCl4-Induced Chronic Liver Disease.

Evidence-based complementary and alternative medicine : eCAM

Xi S,Yue L,Shi M,Peng Y,Xu Y,Wang X,Li Q,Kang Z,Li H,Wang Y

Mon Jun 13 00:00:00 UTC 2016

Evodiamine exerts anti-tumor effects against hepatocellular carcinoma through inhibiting β-catenin-mediated angiogenesis.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine

Shi L,Yang F,Luo F,Liu Y,Zhang F,Zou M,Liu Q

Thu Sep 01 00:00:00 UTC 2016

Evodiamine exerts anti-tumor effects against hepatocellular carcinoma through inhibiting β-catenin-mediated angiogenesis.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine

Shi L,Yang F,Luo F,Liu Y,Zhang F,Zou M,Liu Q

Thu Sep 01 00:00:00 UTC 2016

Heparanase released from mesenchymal stem cells activates integrin beta1/HIF-2alpha/Flk-1 signaling and promotes endothelial cell migration and angiogenesis.

Stem cells (Dayton, Ohio)

Hu X,Zhang L,Jin J,Zhu W,Xu Y,Wu Y,Wang Y,Chen H,Webster KA,Chen H,Yu H,Wang J

Mon Jun 01 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: Embryonic receptor kinase 2; FLT; FLT-1; FMS-like tyrosine kinase 1; Fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor); i21; soluble VEGFR 1; sVEGFR 1; Tyrosine-protein kinase FRT; Tyrosine-protein kinase receptor FLT; Vascular endothelial growth factor receptor 1; vascular endothelial growth factor receptor-1; Vascular permeability factor receptor; VEGF R1; VEGFR-1

View more View less

Gene Aliases: AI323757; Emrk2; FLT; FLT-1; FLT1; FRT; sFlt1; VEGFR-1; VEGFR1

View more View less

UniProt ID: (Human) P17948, (Mouse) P35969

View more View less

Entrez Gene ID: (Human) 2321, (Mouse) 14254, (Rat) 54251

View more View less

Function(s)

transmembrane receptor protein tyrosine kinase activity vascular endothelial growth factor-activated receptor activity protein binding ATP binding growth factor binding VEGF-A-activated receptor activity VEGF-B-activated receptor activity placental growth factor-activated receptor activity nucleotide binding protein kinase activity protein tyrosine kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups identical protein binding receptor signaling protein tyrosine kinase activity

Process(es)

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more

VEGFR-1/FLT-1 Polyclonal Antibody

VEGFR-1/FLT-1 Antibody (13687-1-AP) in ICC/IF

Product Details

13687-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Flow Cytometry (Flow)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

We're here to help

Your items have has been added!