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Invitrogen
VGF Polyclonal Antibody
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Product Details
PA5-63081
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human VGF. Recombinant protein control fragment (Product #RP-101768).
Conjugate
Form
Liquid
Concentration
0.08 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2649426
Product Specific Information
Immunogen sequence: APARDELPDW NEVLPPWDRE EDEVYPPGPY HPFPNYIRPR TLQPPSALRR RHYHHALPPS RHYPGREAQA RRAQEEAEAE ERRLQEQEEL ENYIEHV
Highest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 89%.
Target Information
VGF was initially identified as a rapidly regulated gene product in nerve growth factor-treated PC12 cells. This protein is synthesized in neurons in the central and peripheral nervous system as well as in the pituitary, adrenal medulla, endocrine cells of the stomach, and pancreatic beta cells. VGF is thought to be involved in organism energy balance and regulation of homeostasis as mice lacking this gene show deficits in these areas. More recent results suggest that VGF is upregulated by brain-derived neurotrophic factor (BDNF) and can stimulate the proliferation of hippocampal progenitor cells and produce antidepressant-like behavioral effects, suggesting that this pathway may be a suitable target for therapeutic treatments.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: neuro-endocrine specific protein VGF; Neurosecretory protein VGF
Gene Aliases: SCG7; SgVII; VGF
UniProt ID: (Human) O15240
Entrez Gene ID: (Human) 7425
ovarian follicle development
response to dietary excess
generation of precursor metabolites and energy
response to cold
sexual reproduction
insulin secretion
response to insulin
carbohydrate homeostasis
glucose homeostasis
defense response to bacterium
regulation of synaptic plasticity
response to cAMP
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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