Invitrogen

VIPR1 Polyclonal Antibody

5 Published Figures

7 References

View all (11) VIPR1 antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

Antibody Testing Data (2)
Published Figures (5)

VIPR1 Antibody in Immunohistochemistry (IHC)

FIGURE: 1 / 7

VIPR1 Antibody (PA3-113) in IHC

Immunohistochemical staining of VPAC1 Receptor in human intestine samples using Product # PA3-113.

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Product Details

PA3-113

Applications

Tested Dilution

Publications

Western Blot (WB)

1:250

View 2 publications 2 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:250 - 1:500

View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

1:250 - 1:500

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Guinea pig, Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide, KLH conjugated, corresponding to the residues T(438) R V S P G A R R S S S F Q A E V S L V(457) of human VPAC1 receptor.

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Conc. Not Determined

Storage buffer

whole serum

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

AB_2273050

Product Specific Information

PA3-113 detects VPAC1 Receptor in human samples.

PA3-113 has been successfully used in Western blot, immunocytochemistry and immunohistochemistry (paraffin) procedures. By Western blot, this antibody detects an ~55-70 kDa protein representing VPAC1 Receptor in human samples. In immunohistochemistry, VPAC1 Receptor immunoreactivity is predominantly localized at the level of the plasma membrane.

PA3-113 immunizing peptide corresponds to amino acid residues 438-457 from human VPAC1 Receptor.

Target Information

The Vasoactive Intestinal Polypeptide Receptor 1 (VPAC1) is a member of a family of three G-protein coupled receptors which mediate VIP (vasoactive intestinal peptide) and PACAP (pituitary adenlyate cyclase activating peptide) function in a variety of tissues. Together, the VPAC1 and VPAC2 receptors compose a subtype of the VIP receptor. Expression of the VIP and PACAP receptors has been linked to the presence of human tumors.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

PACAP regulates VPAC1 expression, inflammatory processes and lipid homeostasis in M1- and M2-macrophages.

Frontiers in cardiovascular medicine

Witzel R,Block A,Pollmann S,Oetzel L,Fleck F,Bonaterra GA,Kinscherf R,Schwarz A

Published figure using VIPR1 polyclonal antibody (Product # PA3-113) in Western Blot

Tue Oct 31 00:00:00 UTC 2023

Comprehensive Profiling Reveals Distinct Microenvironment and Metabolism Characterization of Lung Adenocarcinoma.

Frontiers in genetics

Li C,Tian C,Liu Y,Liang J,Zeng Y,Yang Q,Liu Y,Wu D,Wu J,Wang J,Zhang K,Gu F,Hu Y,Liu L

PA3-113 was used in Immunohistochemistry to stratify types of lung adenocarcinoma and their prognostic features based on their tumour microenvironment and metabolism.

Tue Jun 15 00:00:00 UTC 2021

Comprehensive Profiling Reveals Distinct Microenvironment and Metabolism Characterization of Lung Adenocarcinoma.

Frontiers in genetics

Li C,Tian C,Liu Y,Liang J,Zeng Y,Yang Q,Liu Y,Wu D,Wu J,Wang J,Zhang K,Gu F,Hu Y,Liu L

PA3-113 was used in Immunohistochemistry to stratify types of lung adenocarcinoma and their prognostic features based on their tumour microenvironment and metabolism.

Tue Jun 15 00:00:00 UTC 2021

Expression and localization of VPAC1, the major receptor of vasoactive intestinal peptide along the length of the intestine.

American journal of physiology. Gastrointestinal and liver physiology

Jayawardena D,Guzman G,Gill RK,Alrefai WA,Onyuksel H,Dudeja PK

PA3113 was used in immunohistochemistry - paraffin section and western blot to determine VPAC1 distribution and localization

Sat Jul 01 00:00:00 UTC 2017

Expression and localization of VPAC1, the major receptor of vasoactive intestinal peptide along the length of the intestine.

American journal of physiology. Gastrointestinal and liver physiology

Jayawardena D,Guzman G,Gill RK,Alrefai WA,Onyuksel H,Dudeja PK

PA3113 was used in immunohistochemistry - paraffin section and western blot to determine VPAC1 distribution and localization

Sat Jul 01 00:00:00 UTC 2017

Atypical nuclear localization of VIP receptors in glioma cell lines and patients.

Biochemical and biophysical research communications

Barbarin A,Séité P,Godet J,Bensalma S,Muller JM,Chadéneau C

PA3-113 was used in immunocytochemistry, immunohistochemistry - paraffin section, and western blot to study the expression and the nuclear localization of VPAC1 and VPAC2 in glioma

Fri Nov 28 00:00:00 UTC 2014

VPAC1 receptors regulate intestinal secretion and muscle contractility by activating cholinergic neurons in guinea pig jejunum.

American journal of physiology. Gastrointestinal and liver physiology

Fung C,Unterweger P,Parry LJ,Bornstein JC,Foong JP

PA3-113 was used in Immunohistochemistry to show that vasoactive intestinal peptide (VIP) stimulates ACh-mediated longitudinal muscle contraction via VPAC1R on cholinergic motor neurons.

Thu May 01 00:00:00 UTC 2014

The vasoactive intestinal peptide-receptor system is involved in human glioblastoma cell migration.

Neuropeptides

Cochaud S,Chevrier L,Meunier AC,Brillet T,Chadéneau C,Muller JM

PA3-113 was used in western blot to investigate the role of vasoactive intestinal peptide-receptor system in the regulation of human glioblastoma cell migration

Fri Oct 01 00:00:00 UTC 2010

Bioinformatics

Protein Aliases: Pacap receptor; PACAP type II receptor; PACAP-R-2; PACAP-R2; pituitary adenylate cyclase activating polypeptide receptor, type II; Pituitary adenylate cyclase-activating polypeptide type II receptor; Pvr2; type 1 vasoactive intestinal peptide receptor; Vasoactive intestinal polypeptide receptor 1; VIP and PACAP receptor 1; VIP receptor 1; VIP receptor subtype 1; VIP receptor, type I; VIP-R-1; VIP1 receptor; VPAC1 receptor; VPAC1R

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Gene Aliases: AV071699; HVR1; II; PACAP-R-2; PACAP-R2; RDC1; V1RG; VAPC1; VIP-R-1; VIP-R1; VIPR; VIPR1; VIRG; VPAC1; VPAC1R; VPCAP1R

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UniProt ID: (Human) P32241, (Mouse) P97751

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Entrez Gene ID: (Human) 7433, (Mouse) 22354

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Function(s)

vasoactive intestinal polypeptide receptor activity protein binding signal transducer activity transmembrane signaling receptor activity G-protein coupled receptor activity

Process(es)

muscle contraction immune response cell surface receptor signaling pathway G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger chemical synaptic transmission digestion positive regulation of cell proliferation signal transduction

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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VIPR1 Polyclonal Antibody

VIPR1 Antibody (PA3-113) in IHC

Product Details

PA3-113

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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