Proteintech

VNN1 Polyclonal Antibody

VNN1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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VNN1 Antibody (21745-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human pancreas cancer slide using 21745-1-AP ( VNN1 Antibody) at dilution of 1:50 (under 40x lens).

VNN1 Antibody in Immunoprecipitation (IP)

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Product Details

21745-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 8 publications 8 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

VNN1 Fusion Protein Ag16501 (302-513 aa encoded by BC096268)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.37 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: SQLDSHPSH SAVVNWTSYA SSIEALSSGN KEFKGTVFFD EFTFVKLTGV AGNYTVCQKD LCCHLSYKMS ENIPNEVYAL GAFDGLHTVE GRYYLQICTL LKCKTTNLNT CGDSAETAST RFEMFSLSGT FGTQYVFPEV LLSENQLAPG EFQVSTDGRL FSLKPTSGPV LTVTLFGRLY EKDWASNASS GLTAQARIIM LIVIAPIVCS LSW (302-513 aa encoded by BC096268)

Target Information

Hematopoietic precursor cells migrate to the thymus, where they differentiate into mature T lymphocytes. GPI-anchored vanin-1 protein regulates the late adhesion steps of thymus homing of bone marrow precursor cells. Vanin-1 is ubiquitously expressed as a pantetheinase enzyme and catalyzes the hydrolysis of pantetheine for vitamin B5 recycling. The hydrolytic activity of vanin-1 generates the potent antioxidant cysteamine as a metabolite. As a membrane bound pantetheinase, vanin-1 provides the main source of cysteamine under normal physiological conditions. In mice, vanin-1 is expressed specifically in male Sertoli cells of the developing testis, where it aids in cell migration.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Emodin Alleviates Sodium Taurocholate-Induced Pancreatic Ductal Cell Damage by Inhibiting the S100A9/VNN1 Signaling Pathway.

Pancreas

Guo F,Zhou Q,Wu Y,Chen M,Zhao L,Xiang H

Mon Aug 01 00:00:00 UTC 2022

Effects of ABCG1 knockout on proteomic composition of HDL in mice on a chow diet and a high-fat diet.

Proteomics

Wu Y,Chen L,Xie Z,Wang C,Zhang J,Yan X

Sun May 01 00:00:00 UTC 2022

Pancreatic ductal deletion of S100A9 alleviates acute pancreatitis by targeting VNN1-mediated ROS release to inhibit NLRP3 activation.

Theranostics

Xiang H,Guo F,Tao X,Zhou Q,Xia S,Deng D,Li L,Shang D

Mon Jul 26 00:00:00 UTC 2021

Overexpression of B7-H4 promotes renal cell carcinoma progression by recruiting tumor-associated neutrophils via upregulation of CXCL8.

Oncology letters

Li A,Zhang N,Zhao Z,Chen Y,Zhang L

Sat Aug 01 00:00:00 UTC 2020

Dihydroartemisinin inhibits ER stress-mediated mitochondrial pathway to attenuate hepatocyte lipoapoptosis via blocking the activation of the PI3K/Akt pathway.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Chen X,Bian M,Zhang C,Kai J,Yao Z,Jin H,Lu C,Shao J,Chen A,Zhang F,Zheng S

Mon Jan 01 00:00:00 UTC 2018

Dihydroartemisinin inhibits ER stress-mediated mitochondrial pathway to attenuate hepatocyte lipoapoptosis via blocking the activation of the PI3K/Akt pathway.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Chen X,Bian M,Zhang C,Kai J,Yao Z,Jin H,Lu C,Shao J,Chen A,Zhang F,Zheng S

Mon Jan 01 00:00:00 UTC 2018

VNN1 promotes atherosclerosis progression in apoE-/- mice fed a high-fat/high-cholesterol diet.

Journal of lipid research

Hu YW,Wu SG,Zhao JJ,Ma X,Lu JB,Xiu JC,Zhang Y,Huang C,Qiu YR,Sha YH,Gao JJ,Wang YC,Li SF,Zhao JY,Zheng L,Wang Q

Mon Aug 01 00:00:00 UTC 2016

VNN1 promotes atherosclerosis progression in apoE-/- mice fed a high-fat/high-cholesterol diet.

Journal of lipid research

Hu YW,Wu SG,Zhao JJ,Ma X,Lu JB,Xiu JC,Zhang Y,Huang C,Qiu YR,Sha YH,Gao JJ,Wang YC,Li SF,Zhao JY,Zheng L,Wang Q

Mon Aug 01 00:00:00 UTC 2016

Novel Elements of the Chondrocyte Stress Response Identified Using an in Vitro Model of Mouse Cartilage Degradation.

Journal of proteome research

Wilson R,Golub SB,Rowley L,Angelucci C,Karpievitch YV,Bateman JF,Fosang AJ

Fri Mar 04 00:00:00 UTC 2016

Novel Elements of the Chondrocyte Stress Response Identified Using an in Vitro Model of Mouse Cartilage Degradation.

Journal of proteome research

Wilson R,Golub SB,Rowley L,Angelucci C,Karpievitch YV,Bateman JF,Fosang AJ

Fri Mar 04 00:00:00 UTC 2016

Vanin-1 is a key activator for hepatic gluconeogenesis.

Diabetes

Chen S,Zhang W,Tang C,Tang X,Liu L,Liu C

Sun Jun 01 00:00:00 UTC 2014

Vanin-1 is a key activator for hepatic gluconeogenesis.

Diabetes

Chen S,Zhang W,Tang C,Tang X,Liu L,Liu C

Sun Jun 01 00:00:00 UTC 2014

Circulating extracellular vesicles with specific proteome and liver microRNAs are potential biomarkers for liver injury in experimental fatty liver disease.

PloS one

Povero D,Eguchi A,Li H,Johnson CD,Papouchado BG,Wree A,Messer K,Feldstein AE

Thu Jul 23 00:00:00 UTC 2015

Circulating extracellular vesicles with specific proteome and liver microRNAs are potential biomarkers for liver injury in experimental fatty liver disease.

PloS one

Povero D,Eguchi A,Li H,Johnson CD,Papouchado BG,Wree A,Messer K,Feldstein AE

Thu Jul 23 00:00:00 UTC 2015

Lipid-induced toxicity stimulates hepatocytes to release angiogenic microparticles that require Vanin-1 for uptake by endothelial cells.

Science signaling

Povero D,Eguchi A,Niesman IR,Andronikou N,de Mollerat du Jeu X,Mulya A,Berk M,Lazic M,Thapaliya S,Parola M,Patel HH,Feldstein AE

Tue Oct 08 00:00:00 UTC 2013

Lipid-induced toxicity stimulates hepatocytes to release angiogenic microparticles that require Vanin-1 for uptake by endothelial cells.

Science signaling

Povero D,Eguchi A,Niesman IR,Andronikou N,de Mollerat du Jeu X,Mulya A,Berk M,Lazic M,Thapaliya S,Parola M,Patel HH,Feldstein AE

Tue Oct 08 00:00:00 UTC 2013

Bioinformatics

Protein Aliases: Pantetheinase; Pantetheine hydrolase; Tiff66; Vanin-1; Vanin1; vannin 1; Vascular non-inflammatory molecule 1

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Gene Aliases: HDLCQ8; Tiff66; V-1; VNN1

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UniProt ID: (Human) O95497, (Mouse) Q9Z0K8

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Entrez Gene ID: (Human) 8876, (Mouse) 22361

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Function(s)

pantetheine hydrolase activity hydrolase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides GPI anchor binding

Process(es)

acute inflammatory response chronic inflammatory response nitrogen compound metabolic process inflammatory response pantothenate metabolic process single organismal cell-cell adhesion positive regulation of T cell differentiation in thymus innate immune response negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway biotin metabolic process movement of cell or subcellular component response to oxidative stress central nervous system development

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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VNN1 Polyclonal Antibody

VNN1 Antibody (21745-1-AP) in IHC (P)

Product Details

21745-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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