Proteintech

VPS15 Polyclonal Antibody

VPS15 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 4

VPS15 Antibody (17894-1-AP) in ICC/IF

Immunofluorescent analysis of Hela cells, using PIK3R4 antibody 17894-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IGG (red).

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Product Details

17894-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 5 publications 5 publications

Immunocytochemistry (ICC/IF)

1:10-1:100

Immunoprecipitation (IP)

View 1 publication 1 publication

Miscellaneous PubMed (MISC)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

VPS15 Fusion Protein Ag12221 (1-330 aa encoded by BC110318)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MGNQLAGIA PSQILSVESY FSDIHDFEYD KSLGSTRFFK VARAKHREGL VVVKVFAIQD PTLPLTSYKQ ELEELKIRLN SAQNCLPFQK ASEKASEKAA MLFRQYVRDN LYDRISTRPF LNNIEKRWIA FQILTAVDQA HKSGVRHGDI KTENVMVTSW NWVLLTDFAS FKPTYLPEDN PADFNYFFDT SRRRTCYIAP ERFVDGGMFA TELEYMRDPS TPLVDLNSNQ RTRGELKRAM DIFSAGCVIA ELFTEGVPLF DLSQLLAYRN GHFFPEQVLN KIEDHSIREL VTQMIHREPD KRLEAEDYLK QQRGNAFPEI FYTFLQPYMA Q (1-330 aa encoded by BC110318)

Target Information

Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123). [UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Nano-graphene oxide depresses neurotransmission by blocking retrograde transport of mitochondria.

Journal of hazardous materials

Kang Y,Yin S,Liu J,Jiang Y,Huang Z,Chen L,Shao L

Tue Feb 15 00:00:00 UTC 2022

Structural basis for VPS34 kinase activation by Rab1 and Rab5 on membranes.

Nature communications

Tremel S,Ohashi Y,Morado DR,Bertram J,Perisic O,Brandt LTL,von Wrisberg MK,Chen ZA,Maslen SL,Kovtun O,Skehel M,Rappsilber J,Lang K,Munro S,Briggs JAG,Williams RL

Wed Mar 10 00:00:00 UTC 2021

Autophagic elimination of ribosomes during spermiogenesis provides energy for flagellar motility.

Developmental cell

Lei Y,Zhang X,Xu Q,Liu S,Li C,Jiang H,Lin H,Kong E,Liu J,Qi S,Li H,Xu W,Lu K

Mon Aug 23 00:00:00 UTC 2021

IL-6 regulates autophagy and chemotherapy resistance by promoting BECN1 phosphorylation.

Nature communications

Hu F,Song D,Yan Y,Huang C,Shen C,Lan J,Chen Y,Liu A,Wu Q,Sun L,Xu F,Hu F,Chen L,Luo X,Feng Y,Huang S,Hu J,Wang G

Tue Jun 15 00:00:00 UTC 2021

Targeting AR-Beclin 1 complex-modulated growth factor signaling increases the antiandrogen Enzalutamide sensitivity to better suppress the castration-resistant prostate cancer growth.

Cancer letters

Zhang M,Sun Y,Meng J,Zhang L,Liang C,Chang C

Fri Feb 01 00:00:00 UTC 2019

Targeting AR-Beclin 1 complex-modulated growth factor signaling increases the antiandrogen Enzalutamide sensitivity to better suppress the castration-resistant prostate cancer growth.

Cancer letters

Zhang M,Sun Y,Meng J,Zhang L,Liang C,Chang C

Fri Feb 01 00:00:00 UTC 2019

Mutations in Vps15 perturb neuronal migration in mice and are associated with neurodevelopmental disease in humans.

Nature neuroscience

Gstrein T,Edwards A,Přistoupilová A,Leca I,Breuss M,Pilat-Carotta S,Hansen AH,Tripathy R,Traunbauer AK,Hochstoeger T,Rosoklija G,Repic M,Landler L,Stránecký V,Dürnberger G,Keane TM,Zuber J,Adams DJ,Flint J,Honzik T,Gut M,Beltran S,Mechtler K,Sherr E,Kmoch S,Gut I,Keays DA

Thu Feb 01 00:00:00 UTC 2018

Mutations in Vps15 perturb neuronal migration in mice and are associated with neurodevelopmental disease in humans.

Nature neuroscience

Thu Feb 01 00:00:00 UTC 2018

Protective effects of p-nitro caffeic acid phenethyl ester on acute myocardial ischemia-reperfusion injury in rats.

Experimental and therapeutic medicine

DU Q,Hao C,Gou J,Li X,Zou K,He X,Li Z

Fri Apr 01 00:00:00 UTC 2016

Bioinformatics

Protein Aliases: phosphatidylinositol 3-kinase-associated p150; Phosphoinositide 3-kinase adaptor protein; Phosphoinositide 3-kinase regulatory subunit 4; phosphoinositide-3-kinase, regulatory subunit 4; phosphoinositide-3-kinase, regulatory subunit 4, p150; PI3-Kinase p150; PI3-kinase p150 subunit; PI3-kinase regulatory subunit 4; PI3-kinase VPS15

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Gene Aliases: 2210010O15Rik; C730038E05Rik; C85833; D9Ertd418e; p150; PIK3R4; VPS15

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UniProt ID: (Human) Q99570, (Rat) P0C0R5, (Mouse) Q8VD65

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Entrez Gene ID: (Human) 30849, (Rat) 363131, (Mouse) 75669

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Function(s)

protein kinase activity protein serine/threonine kinase activity protein binding ATP binding 1-phosphatidylinositol-3-kinase activity molecular_function nucleotide binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups

Process(es)

protein phosphorylation protein targeting to vacuole biological_process macroautophagy pexophagy late endosome to vacuole transport phosphatidylinositol biosynthetic process regulation of cytokinesis receptor catabolic process toll-like receptor 9 signaling pathway phosphatidylinositol-3-phosphate biosynthetic process cellular response to glucose starvation positive regulation of phosphatidylinositol 3-kinase activity phosphorylation

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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VPS15 Polyclonal Antibody

VPS15 Antibody (17894-1-AP) in ICC/IF

Product Details

17894-1-AP

Western Blot (WB)

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Miscellaneous PubMed (MISC)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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