Proteintech

VPS26B Polyclonal Antibody

VPS26B Antibody in Immunocytochemistry (ICC/IF)

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VPS26B Antibody (15915-1-AP) in ICC/IF

Immunofluorescent analysis of (-20°C Ethanol) fixed HeLa cells using (Product # 15915-1-AP) (VPS26B antibody) at dilution of 1:50 and CoraLite488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L).

VPS26B Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Product Details

15915-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 8 publications 8 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200

Immunocytochemistry (ICC/IF)

1:50

View 1 publication 1 publication

Immunoprecipitation (IP)

Assay-dependent

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

VPS26B Fusion Protein Ag8708 (1-336 aa encoded by BC009747)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.13 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MSFFGFGQS VEVEILLNDA ESRKRAEHKT EDGKKEKYFL FYDGETVSGK VSLALKNPNK RLEHQGIKIE FIGQIELYYD RGNHHEFVSL VKDLARPGEI TQSQAFDFEF THVEKPYESY TGQNVKLRYF LRATISRRLN DVVKEMDIVV HTLSTYPELN SSIKMEVGIE DCLHIEFEYN KSKYHLKDVI VGKIYFLLVR IKIKHMEIDI IKRETTGTGP NVYHENDTIA KYEIMDGAPV RGESIPIRLF LAGYELTPTM RDINKKFSVR YYLNLVLIDE EERRYFKQQE VVLWRKGDIV RKSMSHQAAI ASQRFEGTTS LGEVRTPSQL SDNNCRQ (1-336 aa encoded by BC009747)

Target Information

In mammals, there are two paralogues of yeast Vps26, VPS26A and VPS26B. VPS26 is a component of the retromer complex composed of VPS26 (VPS26A or VPS26B), VPS29, VPS35, SNX1 and SNX2. VPS26A and VPS26B subunits define distinct retromer complexes. The retromer complex is important in recycling transmembrane receptors from endosomes to the trans-Golgi network (TGN).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Retromer Proteins Reduced in Down Syndrome and the Dp16 Model: Impact of APP Dose and Preclinical Studies of a γ-Secretase Modulator.

Annals of neurology

Chen XQ,Sawa M,Becker A,Karachentsev D,Zuo X,Rynearson KD,Tanzi RE,Mobley WC

Tue Aug 01 00:00:00 UTC 2023

VPS35 regulates tau phosphorylation and neuropathology in tauopathy.

Molecular psychiatry

Vagnozzi AN,Li JG,Chiu J,Razmpour R,Warfield R,Ramirez SH,Praticò D

Mon Nov 01 00:00:00 UTC 2021

Sorting nexin 3 induces heart failure via promoting retromer-dependent nuclear trafficking of STAT3.

Cell death and differentiation

Lu J,Xu S,Huo Y,Sun D,Hu Y,Wang J,Zhang X,Wang P,Li Z,Liang M,Wu Z,Liu P

Fri Oct 01 00:00:00 UTC 2021

Sorting nexin 3 induces heart failure via promoting retromer-dependent nuclear trafficking of STAT3.

Cell death and differentiation

Lu J,Xu S,Huo Y,Sun D,Hu Y,Wang J,Zhang X,Wang P,Li Z,Liang M,Wu Z,Liu P

Fri Oct 01 00:00:00 UTC 2021

Sorting nexin 3 induces heart failure via promoting retromer-dependent nuclear trafficking of STAT3.

Cell death and differentiation

Lu J,Xu S,Huo Y,Sun D,Hu Y,Wang J,Zhang X,Wang P,Li Z,Liang M,Wu Z,Liu P

Fri Oct 01 00:00:00 UTC 2021

Full recovery of the Alzheimer's disease phenotype by gain of function of vacuolar protein sorting 35.

Molecular psychiatry

Li JG,Chiu J,Praticò D

Thu Oct 01 00:00:00 UTC 2020

Retromer stabilization results in neuroprotection in a model of Amyotrophic Lateral Sclerosis.

Nature communications

Muzio L,Sirtori R,Gornati D,Eleuteri S,Fossaghi A,Brancaccio D,Manzoni L,Ottoboni L,Feo L,Quattrini A,Mastrangelo E,Sorrentino L,Scalone E,Comi G,Marinelli L,Riva N,Milani M,Seneci P,Martino G

Fri Jul 31 00:00:00 UTC 2020

Dysregulation of the Retromer Complex System in Down Syndrome.

Annals of neurology

Curtis ME,Yu D,Praticò D

Wed Jul 01 00:00:00 UTC 2020

Retromer associates with the cytoplasmic amino-terminus of polycystin-2.

Journal of cell science

Tilley FC,Gallon M,Luo C,Danson CM,Zhou J,Cullen PJ

Wed Jun 06 00:00:00 UTC 2018

Retromer associates with the cytoplasmic amino-terminus of polycystin-2.

Journal of cell science

Tilley FC,Gallon M,Luo C,Danson CM,Zhou J,Cullen PJ

Wed Jun 06 00:00:00 UTC 2018

A unique PDZ domain and arrestin-like fold interaction reveals mechanistic details of endocytic recycling by SNX27-retromer.

Proceedings of the National Academy of Sciences of the United States of America

Gallon M,Clairfeuille T,Steinberg F,Mas C,Ghai R,Sessions RB,Teasdale RD,Collins BM,Cullen PJ

Tue Sep 02 00:00:00 UTC 2014

A unique PDZ domain and arrestin-like fold interaction reveals mechanistic details of endocytic recycling by SNX27-retromer.

Proceedings of the National Academy of Sciences of the United States of America

Gallon M,Clairfeuille T,Steinberg F,Mas C,Ghai R,Sessions RB,Teasdale RD,Collins BM,Cullen PJ

Tue Sep 02 00:00:00 UTC 2014

A unique PDZ domain and arrestin-like fold interaction reveals mechanistic details of endocytic recycling by SNX27-retromer.

Proceedings of the National Academy of Sciences of the United States of America

Gallon M,Clairfeuille T,Steinberg F,Mas C,Ghai R,Sessions RB,Teasdale RD,Collins BM,Cullen PJ

Tue Sep 02 00:00:00 UTC 2014

A unique PDZ domain and arrestin-like fold interaction reveals mechanistic details of endocytic recycling by SNX27-retromer.

Proceedings of the National Academy of Sciences of the United States of America

Gallon M,Clairfeuille T,Steinberg F,Mas C,Ghai R,Sessions RB,Teasdale RD,Collins BM,Cullen PJ

Tue Sep 02 00:00:00 UTC 2014

Bioinformatics

Protein Aliases: Vacuolar protein sorting-associated protein 26B; Vesicle protein sorting 26B; VPS26 retromer complex component B

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Gene Aliases: 1810012I05Rik; 2310075A12Rik; AI848392; Pep8b; VPS26B

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UniProt ID: (Human) Q4G0F5, (Mouse) Q8C0E2

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Entrez Gene ID: (Human) 112936, (Rat) 300472, (Mouse) 69091

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Function(s)

protein transporter activity

Process(es)

intracellular protein transport retrograde transport, endosome to Golgi transport protein transport regulation of macroautophagy

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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VPS26B Polyclonal Antibody

VPS26B Antibody (15915-1-AP) in ICC/IF

Product Details

15915-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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