Proteintech

VPS37A Polyclonal Antibody

VPS37A Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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VPS37A Antibody (11870-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human kidney tissue slide using 11870-1-AP ( VPS37A antibody) at dilution of 1:200 (under 40x lens).

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Product Details

11870-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 10 publications 10 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

VPS37A Fusion Protein Ag2453 (1-174 aa encoded by BC022363)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.33 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MPDVPDAFP ELSELSVSQL TDMNEQEEVL LEQFLTLPQL KQIITDKDDL VKSIEELARK NLLLEPSLEA KRQTVLDKYE LLTQMKSTFE KKMQRQHELS ESCSASALQA RLKVAAHEAE EESDNIAEDF LEGKMEIDDF LSSFMEKRTI CHCRRAKEEK LQQAIAMHSQ FHAPL (1-174 aa encoded by BC022363)

Target Information

This gene belongs to the VPS37 family, and encodes a component of the ESCRT-I (endosomal sorting complex required for transport I) protein complex, required for the sorting of ubiquitinated transmembrane proteins into internal vesicles of multivesicular bodies. Expression of this gene is downregulated in hepatocellular carcinoma, and mutations in this gene are associated with autosomal recessive spastic paraplegia-53. A related pseudogene has been identified on chromosome 5. Alternatively spliced transcript variants have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Vps37a regulates hepatic glucose production by controlling glucagon receptor localization to endosomes.

Cell metabolism

Sekar R,Motzler K,Kwon Y,Novikoff A,Jülg J,Najafi B,Wang S,Warnke AL,Seitz S,Hass D,Gancheva S,Kahl S,Yang B,Finan B,Schwarz K,Okun JG,Roden M,Blüher M,Müller TD,Krahmer N,Behrends C,Plettenburg O,Miaczynska M,Herzig S,Zeigerer A

Tue Nov 01 00:00:00 UTC 2022

Endofin is required for HD-PTP and ESCRT-0 interdependent endosomal sorting of ubiquitinated transmembrane cargoes.

iScience

Kazan JM,Desrochers G,Martin CE,Jeong H,Kharitidi D,Apaja PM,Roldan A,St Denis N,Gingras AC,Lukacs GL,Pause A

Fri Nov 19 00:00:00 UTC 2021

HCRP-1 regulates cell migration, invasion and angiogenesis via Src/ FAK signaling in human prostate cancer.

International journal of biological sciences

Chen F,Wu J,Teng J,Li W,Zheng J,Bai J

Mon Nov 02 00:00:00 UTC 2020

HCRP-1 regulates EGFR-AKT-BIM-mediated anoikis resistance and serves as a prognostic marker in human colon cancer.

Cell death & disease

Chen F,Zhang L,Wu J,Huo F,Ren X,Zheng J,Pei D

Wed Dec 05 00:00:00 UTC 2018

HCRP-1 regulates EGFR-AKT-BIM-mediated anoikis resistance and serves as a prognostic marker in human colon cancer.

Cell death & disease

Chen F,Zhang L,Wu J,Huo F,Ren X,Zheng J,Pei D

Wed Dec 05 00:00:00 UTC 2018

HCRP-1 regulates EGFR-AKT-BIM-mediated anoikis resistance and serves as a prognostic marker in human colon cancer.

Cell death & disease

Chen F,Zhang L,Wu J,Huo F,Ren X,Zheng J,Pei D

Wed Dec 05 00:00:00 UTC 2018

HCRP-1 regulates EGFR-AKT-BIM-mediated anoikis resistance and serves as a prognostic marker in human colon cancer.

Cell death & disease

Chen F,Zhang L,Wu J,Huo F,Ren X,Zheng J,Pei D

Wed Dec 05 00:00:00 UTC 2018

MicroRNA-19a acts as a prognostic marker and promotes prostate cancer progression via inhibiting VPS37A expression.

Oncotarget

Fu F,Wan X,Wang D,Kong Z,Zhang Y,Huang W,Wang C,Wu H,Li Y

Fri Jan 05 00:00:00 UTC 2018

MicroRNA-19a acts as a prognostic marker and promotes prostate cancer progression via inhibiting VPS37A expression.

Oncotarget

Fu F,Wan X,Wang D,Kong Z,Zhang Y,Huang W,Wang C,Wu H,Li Y

Fri Jan 05 00:00:00 UTC 2018

HCRP1 downregulation confers poor prognosis and induces chemoresistance through regulation of EGFR-AKT pathway in human gastric cancer.

Virchows Archiv : an international journal of pathology

Xu H,Miao ZF,Wang ZN,Zhao TT,Xu YY,Song YX,Huang JY,Zhang JY,Liu XY,Wu JH,Xu HM

Fri Dec 01 00:00:00 UTC 2017

HCRP1 downregulation confers poor prognosis and induces chemoresistance through regulation of EGFR-AKT pathway in human gastric cancer.

Virchows Archiv : an international journal of pathology

Xu H,Miao ZF,Wang ZN,Zhao TT,Xu YY,Song YX,Huang JY,Zhang JY,Liu XY,Wu JH,Xu HM

Fri Dec 01 00:00:00 UTC 2017

HCRP1 downregulation confers poor prognosis and induces chemoresistance through regulation of EGFR-AKT pathway in human gastric cancer.

Virchows Archiv : an international journal of pathology

Xu H,Miao ZF,Wang ZN,Zhao TT,Xu YY,Song YX,Huang JY,Zhang JY,Liu XY,Wu JH,Xu HM

Fri Dec 01 00:00:00 UTC 2017

HCRP1 downregulation confers poor prognosis and induces chemoresistance through regulation of EGFR-AKT pathway in human gastric cancer.

Virchows Archiv : an international journal of pathology

Xu H,Miao ZF,Wang ZN,Zhao TT,Xu YY,Song YX,Huang JY,Zhang JY,Liu XY,Wu JH,Xu HM

Fri Dec 01 00:00:00 UTC 2017

HCRP-1 regulates cell migration and invasion via EGFR-ERK mediated up-regulation of MMP-2 with prognostic significance in human renal cell carcinoma.

Scientific reports

Chen F,Deng J,Liu X,Li W,Zheng J

Tue Aug 25 00:00:00 UTC 2015

HCRP-1 regulates cell migration and invasion via EGFR-ERK mediated up-regulation of MMP-2 with prognostic significance in human renal cell carcinoma.

Scientific reports

Chen F,Deng J,Liu X,Li W,Zheng J

Tue Aug 25 00:00:00 UTC 2015

HCRP-1 regulates cell migration and invasion via EGFR-ERK mediated up-regulation of MMP-2 with prognostic significance in human renal cell carcinoma.

Scientific reports

Chen F,Deng J,Liu X,Li W,Zheng J

Tue Aug 25 00:00:00 UTC 2015

HCRP-1 regulates cell migration and invasion via EGFR-ERK mediated up-regulation of MMP-2 with prognostic significance in human renal cell carcinoma.

Scientific reports

Chen F,Deng J,Liu X,Li W,Zheng J

Tue Aug 25 00:00:00 UTC 2015

The molecular basis for selective assembly of the UBAP1-containing endosome-specific ESCRT-I complex.

Journal of cell science

Wunderley L,Brownhill K,Stefani F,Tabernero L,Woodman P

Sat Feb 01 00:00:00 UTC 2014

The molecular basis for selective assembly of the UBAP1-containing endosome-specific ESCRT-I complex.

Journal of cell science

Wunderley L,Brownhill K,Stefani F,Tabernero L,Woodman P

Sat Feb 01 00:00:00 UTC 2014

A founder mutation in Vps37A causes autosomal recessive complex hereditary spastic paraparesis.

Journal of medical genetics

Zivony-Elboum Y,Westbroek W,Kfir N,Savitzki D,Shoval Y,Bloom A,Rod R,Khayat M,Gross B,Samri W,Cohen H,Sonkin V,Freidman T,Geiger D,Fattal-Valevski A,Anikster Y,Waters AM,Kleta R,Falik-Zaccai TC

Sun Jul 01 00:00:00 UTC 2012

A founder mutation in Vps37A causes autosomal recessive complex hereditary spastic paraparesis.

Journal of medical genetics

Zivony-Elboum Y,Westbroek W,Kfir N,Savitzki D,Shoval Y,Bloom A,Rod R,Khayat M,Gross B,Samri W,Cohen H,Sonkin V,Freidman T,Geiger D,Fattal-Valevski A,Anikster Y,Waters AM,Kleta R,Falik-Zaccai TC

Sun Jul 01 00:00:00 UTC 2012

The UBAP1 subunit of ESCRT-I interacts with ubiquitin via a SOUBA domain.

Structure (London, England : 1993)

Agromayor M,Soler N,Caballe A,Kueck T,Freund SM,Allen MD,Bycroft M,Perisic O,Ye Y,McDonald B,Scheel H,Hofmann K,Neil SJ,Martin-Serrano J,Williams RL

Wed Mar 07 00:00:00 UTC 2012

The UBAP1 subunit of ESCRT-I interacts with ubiquitin via a SOUBA domain.

Structure (London, England : 1993)

Agromayor M,Soler N,Caballe A,Kueck T,Freund SM,Allen MD,Bycroft M,Perisic O,Ye Y,McDonald B,Scheel H,Hofmann K,Neil SJ,Martin-Serrano J,Williams RL

Wed Mar 07 00:00:00 UTC 2012

UBAP1 is a component of an endosome-specific ESCRT-I complex that is essential for MVB sorting.

Current biology : CB

Stefani F,Zhang L,Taylor S,Donovan J,Rollinson S,Doyotte A,Brownhill K,Bennion J,Pickering-Brown S,Woodman P

Tue Jul 26 00:00:00 UTC 2011

UBAP1 is a component of an endosome-specific ESCRT-I complex that is essential for MVB sorting.

Current biology : CB

Stefani F,Zhang L,Taylor S,Donovan J,Rollinson S,Doyotte A,Brownhill K,Bennion J,Pickering-Brown S,Woodman P

Tue Jul 26 00:00:00 UTC 2011

Bioinformatics

Protein Aliases: ESCRT-I complex subunit VPS37A; Hepatocellular carcinoma-related protein 1; hVps37A; polyglutamine binding protein 2; vacuolar protein sorting 37 homolog A; Vacuolar protein sorting-associated protein 37A; Vps37A

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Gene Aliases: 2210018P21Rik; 4930592A21Rik; AW261445; D8Ertd531e; HCRP1; PQBP2; SPG53; VPS37A

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UniProt ID: (Human) Q8NEZ2, (Mouse) Q8CHS8

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Entrez Gene ID: (Human) 137492, (Mouse) 52348

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Function(s)

protein binding molecular_function

Process(es)

autophagy protein transport endosomal transport viral life cycle multivesicular body assembly viral budding via host ESCRT complex ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway intracellular transport of virus transport

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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VPS37A Polyclonal Antibody

VPS37A Antibody (11870-1-AP) in IHC (P)

Product Details

11870-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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