Proteintech

VPS39 Polyclonal Antibody

VPS39 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 7

VPS39 Antibody (16219-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded mouse heart tissue slide using 16219-1-AP (VPS39 antibody) at dilution of 1:200 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

VPS39 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

16219-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

View 6 publications 6 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 4 publications 4 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

VPS39 Fusion Protein Ag9267 (537-886 aa encoded by BC015817)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.14 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: ERTVQYLQH LGTENLHLIF SYSVWVLRDF PEDGLKIFTE DLPEVESLPR DRVLGFLIEN FKGLAIPYLE HIIHVWEETG SRFHNCLIQL YCEKVQGLMK EYLLSFPAGK TPVPAGEEEG ELGEYRQKLL MFLEISSYYD PGRLICDFPF DGLLEERALL LGRMGKHEQA LFIYVHILKD TRMAEEYCHK HYDRNKDGNK DVYLSLLRMY LSPPSIHCLG PIKLELLEPK ANLQAALQVL ELHHSKLDTT KALNLLPANT QINDIRIFLE KVLEENAQKK RFNQVLKNLL HAEFLRVQEE RILHQQVKCI ITEEKVCMVC KKKIGNSAFA RYPNGVVVHY FCSKEVNPAD T (537-886 aa encoded by BC015817)

Target Information

VPS39 is the mammalian homolog of the yeast vacuolar protein VAM6, that in mammals, promotes lysosome clustering and fusion in vivo. VPS39 is also thought to modulate the TGF-beta response by coupling the TGF-beta receptor complex to the Smad pathway. Similar to the related protein TRAP1, the VPS39 protein is essential for early embryonic development, with mice lacking VPS39 dying at or before E6. 5.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Consecutive functions of small GTPases guide HOPS-mediated tethering of late endosomes and lysosomes.

Cell reports

Schleinitz A,Pöttgen LA,Keren-Kaplan T,Pu J,Saftig P,Bonifacino JS,Haas A,Jeschke A

Tue Jan 31 00:00:00 UTC 2023

Consecutive functions of small GTPases guide HOPS-mediated tethering of late endosomes and lysosomes.

Cell reports

Schleinitz A,Pöttgen LA,Keren-Kaplan T,Pu J,Saftig P,Bonifacino JS,Haas A,Jeschke A

Tue Jan 31 00:00:00 UTC 2023

SDC1-dependent TGM2 determines radiosensitivity in glioblastoma by coordinating EPG5-mediated fusion of autophagosomes with lysosomes.

Autophagy

Zheng W,Chen Q,Liu H,Zeng L,Zhou Y,Liu X,Bai Y,Zhang J,Pan Y,Shao C

Wed Mar 01 00:00:00 UTC 2023

SGPL1 stimulates VPS39 recruitment to the mitochondria in MICU1 deficient cells.

Molecular metabolism

Jackson J,Wischhof L,Scifo E,Pellizzer A,Wang Y,Piazzesi A,Gentile D,Siddig S,Stork M,Hopkins CE,Händler K,Weis J,Roos A,Schultze JL,Nicotera P,Ehninger D,Bano D

Fri Jul 01 00:00:00 UTC 2022

SGPL1 stimulates VPS39 recruitment to the mitochondria in MICU1 deficient cells.

Molecular metabolism

Jackson J,Wischhof L,Scifo E,Pellizzer A,Wang Y,Piazzesi A,Gentile D,Siddig S,Stork M,Hopkins CE,Händler K,Weis J,Roos A,Schultze JL,Nicotera P,Ehninger D,Bano D

Fri Jul 01 00:00:00 UTC 2022

SGPL1 stimulates VPS39 recruitment to the mitochondria in MICU1 deficient cells.

Molecular metabolism

Jackson J,Wischhof L,Scifo E,Pellizzer A,Wang Y,Piazzesi A,Gentile D,Siddig S,Stork M,Hopkins CE,Händler K,Weis J,Roos A,Schultze JL,Nicotera P,Ehninger D,Bano D

Fri Jul 01 00:00:00 UTC 2022

SGPL1 stimulates VPS39 recruitment to the mitochondria in MICU1 deficient cells.

Molecular metabolism

Jackson J,Wischhof L,Scifo E,Pellizzer A,Wang Y,Piazzesi A,Gentile D,Siddig S,Stork M,Hopkins CE,Händler K,Weis J,Roos A,Schultze JL,Nicotera P,Ehninger D,Bano D

Fri Jul 01 00:00:00 UTC 2022

Global mapping of Salmonella enterica-host protein-protein interactions during infection.

Cell host & microbe

Walch P,Selkrig J,Knodler LA,Rettel M,Stein F,Fernandez K,Viéitez C,Potel CM,Scholzen K,Geyer M,Rottner K,Steele-Mortimer O,Savitski MM,Holden DW,Typas A

Wed Aug 11 00:00:00 UTC 2021

ORF3a of SARS-CoV-2 promotes lysosomal exocytosis-mediated viral egress.

Developmental cell

Chen D,Zheng Q,Sun L,Ji M,Li Y,Deng H,Zhang H

Mon Dec 06 00:00:00 UTC 2021

ORF3a of SARS-CoV-2 promotes lysosomal exocytosis-mediated viral egress.

Developmental cell

Chen D,Zheng Q,Sun L,Ji M,Li Y,Deng H,Zhang H

Mon Dec 06 00:00:00 UTC 2021

Cellular mechanotransduction relies on tension-induced and chaperone-assisted autophagy.

Current biology : CB

Ulbricht A,Eppler FJ,Tapia VE,van der Ven PF,Hampe N,Hersch N,Vakeel P,Stadel D,Haas A,Saftig P,Behrends C,Fürst DO,Volkmer R,Hoffmann B,Kolanus W,Höhfeld J

Mon Mar 04 00:00:00 UTC 2013

Cellular mechanotransduction relies on tension-induced and chaperone-assisted autophagy.

Current biology : CB

Ulbricht A,Eppler FJ,Tapia VE,van der Ven PF,Hampe N,Hersch N,Vakeel P,Stadel D,Haas A,Saftig P,Behrends C,Fürst DO,Volkmer R,Hoffmann B,Kolanus W,Höhfeld J

Mon Mar 04 00:00:00 UTC 2013

Merkel cell polyomavirus large T antigen disrupts lysosome clustering by translocating human Vam6p from the cytoplasm to the nucleus.

The Journal of biological chemistry