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Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MHDAFEPVPI LEKLPLQIDC LAAWEEWLLV GTKQGHLLLY RIRKDVGCNR FEVTLEKSNK NFSKKIQQIH VVSQFKILVS LLENNIYVHD LLTFQQITTV SKAKGASLFT CDLQHTETGE EVLRMCVAVK KKLQLYFWKD REFHELQGDF SVPDVPKSMA WCENSICVGF KRDYYLIRVD GKGSIKELFP TGKQLEPLVA PLADGKVAVG QDDLTVVLNE EGICTQKCAL NWTDIPVAME HQPPYIIAVL PRYVEIRTFE PRLLVQSIEL QRPRFITSGG SNIIYVASNH FVWRLIPVPM ATQIQQLLQD KQFELALQLA EMKDDSDSEK QQQIHHIKNL YAFNLFCQKR FDESMQVFAK LGTDPTHVMG LYPDLLPTDY RKQLQYPNPL PVLSGAELEK AHLALIDYLT QKRSQLVKKL NDSDHQSSTS PLMEGTPTIK SKKKLLQIID TTLLKCYLHT NVALVAPLLR LENNHCHIEE SEHVLKKAHK YSELIILYEK KGLHEKALQV LVDQSKKANS PLKGHERTVQ YLQHLGTENL HLIFSYSVWV LRDFPEDGLK IFTEDLPEVE SLPRDRVLGF LIENFKGLAI PYLEHIIHVW EETGSRFHNC LIQLYCEKVQ GLMKEYLLSF PAGKTPVPAG EEEGELGEYR QKLLMFLEIS SYYDPGRLIC DFPFDGLLEE RALLLGRMGK HEQALFIYVH ILKDTRMAEE YCHKHYDRNK DGNKDVYLSL LRMYLSPPSI HCLGPIKLEL LEPKANLQAA LQVLELHHSK LDTTKALNLL PANTQINDIR IFLEKVLEEN AQKKRFNQVL KNLLHAEFLR VQEERILHQQ VKCIITEEKV CMVCKKKIGN SAFARYPNGV VVHYFCSKEV NPADT
VPS39 is the mammalian homolog of the yeast vacuolar protein VAM6, that in mammals, promotes lysosome clustering and fusion in vivo. VPS39 is also thought to modulate the TGF-beta response by coupling the TGF-beta receptor complex to the Smad pathway. Similar to the related protein TRAP1, the VPS39 protein is essential for early embryonic development, with mice lacking VPS39 dying at or before E6. 5.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: hVam6p; OTTMUSP00000023341; OTTMUSP00000023350; PI3K type 3; TRAP1-like protein; vacuolar protein sorting 39 homolog; Vam6/Vps39-like protein; VPS39 HOPS complex subunit
Gene Aliases: hVam6p; KIAA0770; TLP; VAM6; VPS39
UniProt ID: (Human) Q96JC1
Entrez Gene ID: (Human) 23339
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