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Invitrogen
VPS39 Polyclonal Antibody
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FIGURE: 1 / 1
VPS39 Antibody (PA5-88969) in WB
Western blot analysis of VPS39 in extracts of Rat brain. Samples were incubated with VPS39 Polyclonal antibody (Product # PA5-88969) using a dilution of 1:500, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 180s.
Product Details
PA5-88969
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 606-875 of human VPS39 (NP_0561042)
Conjugate
Form
Liquid
Concentration
2.01 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2805263
Product Specific Information
Immunogen sequence: RFHNCLIQLY CEKVQGLMKE YLLSFPAGKT PVPAGEEEGE LGEYRQKLLM FLEISSYYDP GRLICDFPFD GLLEERALLL GRMGKHEQAL FIYVHILKDT RMAEEYCHKH YDRNKDGNKD VYLSLLRMYL SPPSIHCLGP IKLELLEPKA NLQAALQVLE LHHSKLDTTK ALNLLPANTQ INDIRIFLEK VLEENAQKKR FNQVLKNLLH AEFLRVQEER ILHQQVKCII TEEKVCMVCK KKIGNSAFAR YPNGVVVHYF CSKEVNPADT; Positive Samples: U-87MG, 293T, A-549; Cellular Location: Cytoplasm, Late endosome, Late endosome membrane, Lysosome, Lysosome membrane, Peripheral membrane protein
Target Information
VPS39 is the mammalian homolog of the yeast vacuolar protein VAM6, that in mammals, promotes lysosome clustering and fusion in vivo. VPS39 is also thought to modulate the TGF-beta response by coupling the TGF-beta receptor complex to the Smad pathway. Similar to the related protein TRAP1, the VPS39 protein is essential for early embryonic development, with mice lacking VPS39 dying at or before E6. 5.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hVam6p; OTTMUSP00000023341; OTTMUSP00000023350; PI3K type 3; TRAP1-like protein; vacuolar protein sorting 39 homolog; Vam6; Vam6/Vps39-like protein; VPS39 HOPS complex subunit
Gene Aliases: A230065P22Rik; AW743070; hVam6p; KIAA0770; mVam6; Pldn; TLP; VAM6; Vam6P; VPS39
UniProt ID: (Human) Q96JC1, (Mouse) Q8R5L3
Entrez Gene ID: (Human) 23339, (Rat) 362199, (Mouse) 269338
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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