Proteintech

VPS41 Polyclonal Antibody

VPS41 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 4

VPS41 Antibody (13869-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human liver tissue slide using 13869-1-AP ( VPS41 Antibody) at dilution of 1:200 (under 40x lens).

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Product Details

13869-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200-1:1,000

View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Immunoprecipitation (IP)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

VPS41 Fusion Protein Ag4760 (504-854 aa encoded by BC044851)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.31 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: DSQNKTLLK TLAELYTYDK NYGNALEIYL TLRHKDVFQL IHKHNLFSSI KDKIVLLMDF DSEKAVDMLL DNEDKISIKK VVEELEDRPE LQHVYLHKLF KRDHHKGQRY HEKQISLYAE YDRPNLLPFL RDSTHCPLEK ALEICQQRNF VEETVYLLSR MGNSRSALKM IMEELHDVDK AIEFAKEQDD GELWEDLILY SIDKPPFITG LLNNIGTHVD PILLIHRIKE GMEIPNLRDS LVKILQDYNL QILLREGCKK ILVADSLSLL KKMHRTQMKG VLVDEENICE SCLSPILPSD AAKPFSVVVF HCRHMFHKEC LPMPSMNSAA QFCNICSAKN RGPGSAILEM KK (504-854 aa encoded by BC044851)

Target Information

Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human ortholog of yeast Vps41 protein which is also conserved in Drosophila, tomato, and Arabidopsis. Expression studies in yeast and human indicate that this protein may be involved in the formation and fusion of transport vesicles from the Golgi. Several transcript variants encoding different isoforms have been described for this gene, however, the full-length nature of not all is known.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

SDC1-dependent TGM2 determines radiosensitivity in glioblastoma by coordinating EPG5-mediated fusion of autophagosomes with lysosomes.

Autophagy

Zheng W,Chen Q,Liu H,Zeng L,Zhou Y,Liu X,Bai Y,Zhang J,Pan Y,Shao C

Wed Mar 01 00:00:00 UTC 2023

ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation.

Developmental cell

Miao G,Zhao H,Li Y,Ji M,Chen Y,Shi Y,Bi Y,Wang P,Zhang H

Mon Feb 22 00:00:00 UTC 2021

ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation.

Developmental cell

Miao G,Zhao H,Li Y,Ji M,Chen Y,Shi Y,Bi Y,Wang P,Zhang H

Mon Feb 22 00:00:00 UTC 2021

ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation.

Developmental cell

Miao G,Zhao H,Li Y,Ji M,Chen Y,Shi Y,Bi Y,Wang P,Zhang H

Mon Feb 22 00:00:00 UTC 2021

The topology of the lymphotoxin β receptor that accumulates upon endolysosomal dysfunction dictates the NF-κB signaling outcome.

Journal of cell science

Banach-Orłowska M,Jastrzębski K,Cendrowski J,Maksymowicz M,Wojciechowska K,Korostyński M,Moreau D,Gruenberg J,Miaczynska M

Wed Nov 21 00:00:00 UTC 2018

The topology of the lymphotoxin β receptor that accumulates upon endolysosomal dysfunction dictates the NF-κB signaling outcome.

Journal of cell science

Banach-Orłowska M,Jastrzębski K,Cendrowski J,Maksymowicz M,Wojciechowska K,Korostyński M,Moreau D,Gruenberg J,Miaczynska M

Wed Nov 21 00:00:00 UTC 2018

The topology of the lymphotoxin β receptor that accumulates upon endolysosomal dysfunction dictates the NF-κB signaling outcome.

Journal of cell science

Banach-Orłowska M,Jastrzębski K,Cendrowski J,Maksymowicz M,Wojciechowska K,Korostyński M,Moreau D,Gruenberg J,Miaczynska M

Wed Nov 21 00:00:00 UTC 2018

The topology of the lymphotoxin β receptor that accumulates upon endolysosomal dysfunction dictates the NF-κB signaling outcome.

Journal of cell science

Banach-Orłowska M,Jastrzębski K,Cendrowski J,Maksymowicz M,Wojciechowska K,Korostyński M,Moreau D,Gruenberg J,Miaczynska M

Wed Nov 21 00:00:00 UTC 2018

Characterization of the Mammalian CORVET and HOPS Complexes and Their Modular Restructuring for Endosome Specificity.

The Journal of biological chemistry

van der Kant R,Jonker CT,Wijdeven RH,Bakker J,Janssen L,Klumperman J,Neefjes J

Fri Dec 18 00:00:00 UTC 2015

Characterization of the Mammalian CORVET and HOPS Complexes and Their Modular Restructuring for Endosome Specificity.

The Journal of biological chemistry

van der Kant R,Jonker CT,Wijdeven RH,Bakker J,Janssen L,Klumperman J,Neefjes J

Fri Dec 18 00:00:00 UTC 2015

Late endosomal transport and tethering are coupled processes controlled by RILP and the cholesterol sensor ORP1L.

Journal of cell science

van der Kant R,Fish A,Janssen L,Janssen H,Krom S,Ho N,Brummelkamp T,Carette J,Rocha N,Neefjes J

Thu Aug 01 00:00:00 UTC 2013

Late endosomal transport and tethering are coupled processes controlled by RILP and the cholesterol sensor ORP1L.

Journal of cell science

van der Kant R,Fish A,Janssen L,Janssen H,Krom S,Ho N,Brummelkamp T,Carette J,Rocha N,Neefjes J

Thu Aug 01 00:00:00 UTC 2013

Bioinformatics

Protein Aliases: mVAM2; S53; vacuolar assembly protein 41; vacuolar protein sorting 41 homolog; Vacuolar protein sorting-associated protein 41 homolog; VAM2 homolog; VPS41 HOPS complex subunit

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Gene Aliases: AI317346; HVPS41; hVps41p; HVSP41; mVam2; Vam2; VPS41

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UniProt ID: (Human) P49754, (Mouse) Q5KU39

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Entrez Gene ID: (Human) 27072, (Mouse) 218035

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Function(s)

protein binding microtubule binding zinc ion binding identical protein binding protein self-association GTPase binding metal ion binding

Process(es)

protein targeting to vacuole transport intracellular protein transport protein transport vesicle-mediated transport regulation of SNARE complex assembly vacuole fusion, non-autophagic Golgi vesicle transport autophagy endosome to lysosome transport endosomal vesicle fusion regulated exocytosis late endosome to lysosome transport

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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VPS41 Polyclonal Antibody

VPS41 Antibody (13869-1-AP) in IHC (P)

Product Details

13869-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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