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Proteintech
VPS4A Polyclonal Antibody
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Product Details
14272-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
VPS4A Fusion Protein Ag5592 (86-437 aa encoded by BC047932)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: KENQSEGKG SDSDSEGDNP EKKKLQEQLM GAVVMEKPNI RWNDVAGLEG AKEALKEAVI LPIKFPHLFT GKRTPWRGIL LFGPPGTGKS YLAKAVATEA NNSTFFSVSS SDLMSKWLGE SEKLVKNLFE LARQHKPSII FIDEVDSLCG SRNENESEAA RRIKTEFLVQ MQGVGNNNDG TLVLGATNIP WVLDSAIRRR FEKRIYIPLP EEAARAQMFR LHLGSTPHNL TDANIHELAR KTEGYSGADI SIIVRDSLMQ PVRKVQSATH FKKVCGPSRT NPSMMIDDLL TPCSPGDPGA MEMTWMDVPG DKLLEPVVCM SDMLRSLATT RPTVNADDLL KVKKFSEDFG QES (86-437 aa encoded by BC047932)
Target Information
The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. The mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be really an yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 16; the gene for the other resides on chromosome 18.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: hVPS4; Protein SKD2; SKD1-homolog; vacuolar protein sorting 4a; vacuolar protein sorting factor 4A; vacuolar protein sorting protein 4a; Vacuolar protein sorting-associated protein 4A; vacuolar sorting protein 4; VPS4-1; VPS4A
Gene Aliases: 4930589C15Rik; AI325971; AW553189; SKD1; SKD1A; SKD2; VPS4; VPS4-1; vps4-A; VPS4A
UniProt ID: (Human) Q9UN37, (Rat) Q793F9, (Mouse) Q8VEJ9
Entrez Gene ID: (Human) 27183, (Rat) 246772, (Mouse) 116733
cell separation after cytokinesis
nucleus organization
vacuole organization
mitotic metaphase plate congression
metabolic process
abscission
protein transport
vesicle-mediated transport
endosomal transport
cytoplasmic microtubule organization
negative regulation of cytokinesis
viral budding via host ESCRT complex
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
cell division
ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway
regulation of protein localization to plasma membrane
positive regulation of exosomal secretion
positive regulation of viral budding via host ESCRT complex
membrane budding
autophagy
viral life cycle
viral release from host cell
intracellular cholesterol transport
regulation of protein localization
endosomal vesicle fusion
multivesicular body assembly
late endosomal microautophagy
vesicle uncoating
positive regulation of viral release from host cell
positive regulation of viral life cycle
ESCRT complex disassembly
ESCRT III complex disassembly
transport
cell cycle
positive regulation of viral process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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