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Invitrogen
VPS4A Polyclonal Antibody
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Product Details
PA5-34846
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human VPS4A. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2552198
Product Specific Information
Recommended positive controls: MCF-7.
Predicted reactivity: Mouse (98%), Rat (98%), Zebrafish (90%), Xenopus laevis (92%), Pig (96%), Rhesus Monkey (100%), Bovine (98%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. The mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be really an yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 16; the gene for the other resides on chromosome 18.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hVPS4; Protein SKD2; SKD1-homolog; vacuolar protein sorting factor 4A; Vacuolar protein sorting-associated protein 4A; vacuolar sorting protein 4; VPS4-1; VPS4A
Gene Aliases: SKD1; SKD1A; SKD2; VPS4; VPS4-1; VPS4A
UniProt ID: (Human) Q9UN37
Entrez Gene ID: (Human) 27183
cell separation after cytokinesis
membrane budding
autophagy
nucleus organization
vacuole organization
mitotic metaphase plate congression
abscission
protein transport
vesicle-mediated transport
endosomal transport
viral life cycle
viral release from host cell
cytoplasmic microtubule organization
intracellular cholesterol transport
negative regulation of cytokinesis
regulation of protein localization
endosomal vesicle fusion
multivesicular body assembly
viral budding via host ESCRT complex
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
cell division
late endosomal microautophagy
vesicle uncoating
ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway
positive regulation of viral release from host cell
regulation of protein localization to plasma membrane
positive regulation of exosomal secretion
positive regulation of viral budding via host ESCRT complex
positive regulation of viral life cycle
ESCRT complex disassembly
ESCRT III complex disassembly
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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