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Abnova
VPS53 Polyclonal Antibody, MaxPab™
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Product Details
H00055275-B01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
VPS53 (NP_060759, 1 a.a. approximately 670 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
0.5-1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MMEEEELEFV EELEAVLQLT PEVQLAIEQV FPSQDPLDRA DFNAVEYINT LFPTEQSLAN IDEVVNKIRL KIRRLDDNIR TVVRGQTNVG QDGRQVKEIT RDIKQLDHAK RHLTTSITTL NHLHMLAGGV DSLEAMTRRR QYGEVANLLQ GVMNVLEHFH KYMGIPQIRQ LSERVKAAQT ELGQQILADF EEAFPSQGTK RPGGPSNVLR DACLVANILD PRIKQEIIKK FIKQHLSEYL VLFQENQDVA WLDKIDRRYA WIKRQLVDYE EKYGRMFPRE WCMAERIAVE FCHVTRAELA KIMRTRAKEI EVKLLLFAIQ RTTNFEGFLA KRFSGCTLTD GTLKKLESPP PSTNPFLEDE PTPEMEELAT EKGDLDQPKK PKAPDNPFHG IVSKCFEPHL YVYIESQDKN LGELIDRFVA DFKAQGPPKP NTDEGGAVLP SCADLFVYYK KCMVQCSQLS TGEPMIALTT IFQKYLREYA WKILSGNLPK TTTSSGGLTI SSLLKEKEGS EVAKFTLEEL CLICNILSTA EYCLATTQQL EEKLKEKVDV SLIERINLTG EMDTFSTVIS SSIQLLVQDL DAACDPALTA MSKMQWQNVE HVGDQSPYVT SVILHIKQNV PIIRDNLAST RKYFTQFCVK FANSFIPKFI THLFKCKPIS MVGAEQVRWT
Target Information
The sorting of acid hydrolases to lysosomes rely on mannose 6-phosphate receptors that cycle between the trans-Golgi network (TGN) and endosomes. The maintenance of this cycle requires the function of the mammalian Golgi-associated retrograde protein (GARP) complex which is composed of three subunits: VPS52, VPS53, and VPS54. Depletion of any of these three proteins, such as by RNAi, impairs the retrograde transport of multiple TGN proteins. VPS53 was identified as an HIV dependency factor (HDF) and plays a role in viral entry to the cell, suggesting that VPS53 may be an important drug target in HIV treatment. At least five isoforms of VPS53 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Vacuolar protein sorting-associated protein 53 homolog; VPS53 GARP complex subunit
Gene Aliases: HCCS1; hVps53L; PCH2E; PP13624; VPS53
UniProt ID: (Human) Q5VIR6
Entrez Gene ID: (Human) 55275
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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