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NeoBiotechnologies
Vinculin (Marker of Age-related Macular Degeneration) Recombinant Rabbit Monoclonal Antibody (VCL/7091R)
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FIGURE: 1 / 3
Vinculin (Marker of Age-related Macular Degeneration) Antibody (7414-RBM6-P1ABX) in IHC (P)
Formalin-fixed, paraffin-embedded human placenta stained with Vinculin Recombinant Rabbit Monoclonal Antibody (VCL/7091R) at 2 µg/mL. Inset: PBS instead of primary antibody; secondary only negative control.
Product Details
7414-RBM6-P1ABX
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
VCL/7091R
Immunogen
Recombinant fragment (around aa 174-322) of human Vinculin (VCL) protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A/G
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Vinculin (VCL) is a cytoskeletal protein associated with cell-cell and cell-extracellular matrix adherens-type junctions. It functions as one of several interacting proteins involved in anchoring F-actin to the membrane. It has been shown that a sequence of molecular interactions might be involved in the transmembrane assembly of adhesion plaques. In the assembly of adhesion plaques, the beta subunit of integrin binds to talin. Talin binds to vinculin that interacts with alpha-actinin and possibly with itself. Since alpha-actinin binds to and cross-links actin filaments, vinculin represents a key element in the transmembrane linkage of the extracellular matrix to the cytoplasmic microfilament system. Mutations in the gene can result in cardiomyopathy dilated 1W or familial hypertrophic 15.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: epididymis luminal protein 114; Metavinculin; MV; RP11-178G16.3; vinc; Vinculin
Gene Aliases: 9430097D22; AA571387; AI462105; AW545629; CMD1W; CMH15; HEL114; MV; MVCL; VCL
UniProt ID: (Human) P18206, (Mouse) Q64727
Entrez Gene ID: (Human) 7414, (Mouse) 22330
morphogenesis of an epithelium
cell adhesion
cell-matrix adhesion
lamellipodium assembly
regulation of cell migration
adherens junction assembly
protein localization to cell surface
apical junction assembly
axon extension
platelet aggregation
epithelial cell-cell adhesion
platelet degranulation
movement of cell or subcellular component
muscle contraction
negative regulation of cell migration
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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