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Invitrogen
Viperin Monoclonal Antibody (MaP.VIP)
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Product Details
MA5-49101
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
MaP.VIP
Immunogen
Recombinant mouse viperin fragment (residues 92-362)
Conjugate
Form
Liquid
Concentration
100 µg/mL
Purification
Protein G
Storage buffer
PBS with 0.1% BSA
Contains
0.02% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_3091091
Target Information
Viperin is a 43kDa protein which is one of several hundred interferon inducible viral proteins. Elevated expression of viperin is induced by LPS and poly I:C through TLR dependent signaling pathways. Sendai virus mediated viperin expression is induced independently of TLR signaling pathways through RLRs - RIG-I and MAVs (Severa, 2006). Viperin has been shown to play an important role in interferon mediated anti-viral activity in a Hepatitis C virus model system (Helbig, 2011). Viperin is induced in lymphoid cells and dendritic cells (DCs) and highly induced in neutrophils and macrophages during acute LCMV infection in mice (Hinson, ). Viperin functions as a mediator of viral resistance and as a marker for interferon responsiveness making its detection and mechanism of action through specific antibody probes valuable for further studies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Radical S-adenosyl methionine domain-containing protein 2; rsad2; S-adenosylmethionine-dependent nucleotide dehydratase RSAD2; SAND; VHSV-induced-like protein; Viperin; viral hemorrhagic septicemia virus (VHSV)-induced gene 1; Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible
Gene Aliases: 2510004L01Rik; cig5; Rsad2; Vig1
UniProt ID: (Mouse) Q8CBB9
Entrez Gene ID: (Mouse) 58185
ossification
immune system process
response to virus
regulation of ossification
positive regulation of toll-like receptor 7 signaling pathway
positive regulation of toll-like receptor 9 signaling pathway
CD4-positive, alpha-beta T cell activation
CD4-positive, alpha-beta T cell differentiation
negative regulation of viral genome replication
innate immune response
negative regulation of protein secretion
defense response to virus
positive regulation of T-helper 2 cell cytokine production
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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